Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms

Curcumin Prevents Acute Neuroinflammation and Long-Term Memory Impairment Induced by Systemic Lipopolysaccharide in Mice

(2018) Vincenzo Sorrenti et al.   Frontiers in Pharmacology

Novel Object Recognition as a Facile Behavior Test for Evaluating Drug Effects in AβPP/PS1 Alzheimer's Disease Mouse Model

(2018) Ru Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington’s Disease

(2018) Anne Ast et al.   MOLECULAR CELL

Chrysophanol suppresses pro-inflammatory response in microglia via regulation of Drp1-dependent mitochondrial fission

(2017) Unbin Chae et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Acetaminophen attenuates lipopolysaccharide-induced cognitive impairment through antioxidant activity

(2017) Wei-Xing Zhao et al.   Journal of Neuroinflammation

Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch

(2017) E. F. E. Kuiper et al.   Frontiers in Neuroscience

The Evidence for the Spread and Seeding Capacities of the Mutant Huntingtin Protein in in Vitro Systems and Their Therapeutic Implications

(2017) Maria Masnata et al.   Frontiers in Neuroscience

Human-to-mouse prion-like propagation of mutant huntingtin protein

(2016) Iksoo Jeon et al.   ACTA NEUROPATHOLOGICA

Longitudinal Psychiatric Symptoms in Prodromal Huntington’s Disease: A Decade of Data

(2016) Eric A. Epping et al.   AMERICAN JOURNAL OF PSYCHIATRY

Is Huntington's disease a tauopathy?

(2016) Maud Gratuze et al.   BRAIN

Prions: Beyond a Single Protein

(2016) Alvin S. Das et al.   CLINICAL MICROBIOLOGY REVIEWS

Comparison of mHTT Antibodies in Huntington’s Disease Mouse Models Reveal Specific Binding Profiles and Steady-State Ubiquitin Levels with Disease Development

(2016) Zubeyde Bayram-Weston et al.   PLoS One

Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

(2016) Junhua Yang et al.   eLife

The role of tau in the pathological process and clinical expression of Huntington’s disease

(2015) Romina Vuono et al.   BRAIN

Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

(2015) Jong-Min Lee et al.   CELL

Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and L-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease

(2015) C. B. Divito et al.   JOURNAL OF NEUROSCIENCE

Binding, internalization and fate of Huntingtin Exon1 fibrillar assemblies in mitotic and nonmitotic neuroblastoma cells

(2015) G. Ruiz-Arlandis et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Everyday cognition in prodromal Huntington disease.

(2015) Janet K. Williams et al.   NEUROPSYCHOLOGY

Mutant huntingtin is present in neuronal grafts in huntington disease patients

(2014) Francesca Cicchetti et al.   ANNALS OF NEUROLOGY

Molecular Interaction between the Chaperone Hsc70 and the N-terminal Flank of Huntingtin Exon 1 Modulates Aggregation

(2014) Elodie Monsellier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

(2014) Andrea Crotti et al.   NATURE NEUROSCIENCE

Assessment of mouse anxiety-like behavior in the light–dark box and open-field arena: Role of equipment and procedure

(2014) Natalia Kulesskaya et al.   PHYSIOLOGY & BEHAVIOR

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

(2013) Sarah J Tabrizi et al.   LANCET NEUROLOGY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Striatal Pre-Enkephalin Overexpression Improves Huntington’s Disease Symptoms in the R6/2 Mouse Model of Huntington’s Disease

(2013) Stéphanie Bissonnette et al.   PLoS One

Fibrillar α-Synuclein and Huntingtin Exon 1 Assemblies Are Toxic to the Cells

(2012) Laura Pieri et al.   BIOPHYSICAL JOURNAL

Transmissible Proteins: Expanding the Prion Heresy

(2012) Claudio Soto   CELL

Huntingtonʼs disease

(2012) Ainhi D. Ha et al.   CURRENT OPINION IN NEUROLOGY

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Sex Effects in Mouse Prion Disease Incubation Time

(2011) Shaheen Akhtar et al.   PLoS One

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

L-DOPA reverses motor deficits associated with normal aging in mice

(2010) Erika Allen et al.   NEUROSCIENCE LETTERS

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

(2010) Stephan J. Guyenet et al.   Jove-Journal of Visualized Experiments

Huntington's disease: The current state of research with peripheral tissues

(2009) Jenny Sassone et al.   EXPERIMENTAL NEUROLOGY

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

(2009) Pei-Hsien Ren et al.   NATURE CELL BIOLOGY

Intrasession and intersession habituation in mice: From inbred strain variability to linkage analysis

(2009) Valerie J. Bolivar   NEUROBIOLOGY OF LEARNING AND MEMORY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The current clinical management of Huntington's disease

(2008) Wendy Phillips et al.   MOVEMENT DISORDERS