Friedel-Crafts Reaction of Indoles with Isatin-Derived β,γ-Unsaturated α-Keto Esters Using a BINOL-Derived Bisoxazoline (BOX)/Copper(II) Complex as Catalyst

Chiral Imidodiphosphoric Acids-Catalyzed Friedel-Crafts Reactions of Indoles/Pyrroles with 3-Hydroxy-indolyloxindoles: Enantioselective Synthesis of 3,3-Diaryloxindoles

(2016) Ming-Hua Zhuo et al.   ADVANCED SYNTHESIS & CATALYSIS

Reversal of enantioselective Friedel–Crafts C3-alkylation of pyrrole by slightly tuning the amide units of N,N′-dioxide ligands

(2015) Yulong Zhang et al.   CHEMICAL COMMUNICATIONS

Antiviral enantiomers of a bisindole alkaloid with a new carbon skeleton from the roots of Isatis indigotica

(2015) Yu-Feng Liu et al.   CHINESE CHEMICAL LETTERS

Ni-Catalyzed Highly Chemo-, Regio-, and Enantioselective Decarboxylative Aldol Reaction of β,γ-Unsaturated α-Ketoesters with β-Ketoacids

(2015) Ai-Jia Wei et al.   JOURNAL OF ORGANIC CHEMISTRY

A highly diastereoselective Friedel–Crafts reaction of indoles with isatin-derived N-sulfinyl ketimines towards the efficient synthesis of chiral tetrasubstituted 3-indolyl-3-aminooxindoles

(2015) Jian-Ping Chen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Efficient Synthesis of 3,3′-Mixed Bisindoles via Lewis Acid Catalyzed Reaction of Spiro-epoxyoxindoles and Indoles

(2015) Saumen Hajra et al.   ORGANIC LETTERS

Catalytic Asymmetric Four-Component Reaction for the Rapid Construction of 3,3-Disubstituted 3-Indol-3′-yloxindoles

(2015) Changcheng Jing et al.   ORGANIC LETTERS

Copper Catalyzed Enantioselective Alkylation of Pyrrole with β,γ-Unsaturated α-Ketoesters: Application to One-Pot Construction of the Seven-Membered Ring by Merging a Gold Catalysis

(2015) Yanbin Hu et al.   ORGANIC LETTERS

Chiral Phosphoric Acid Catalyzed Enantioselective Decarboxylative Alkylation of β-Keto Acids with 3-Hydroxy-3-indolyloxindoles

(2015) Xiao-Dong Tang et al.   ORGANIC LETTERS

Recent Advances in Chiral Phosphoric Acid Catalyzed Asymmetric Reactions for the Synthesis of Enantiopure Indole Derivatives

(2015) Hua Wu et al.   SYNTHESIS-STUTTGART

Heteroarylidene-tethered bis(oxazoline) copper complexes catalyzed cascade reaction involving asymmetric Friedel–Crafts alkylation/N-hemiacetalization of indoles with β,γ-unsaturated α-ketoester

(2015) Hong-Li Ma et al.   TETRAHEDRON

Enantioselective Synthesis of Polycyclic Indole Derivatives Based on aza-Morita–Baylis–Hillman Reaction

(2015) Yuning Gao et al.   ACS Catalysis

Synthesis of a chiral fluorescence active probe and its application as an efficient catalyst in the asymmetric Friedel–Crafts alkylation of indole derivatives with nitroalkenes

(2015) Ganesh Vasant More et al.   Catalysis Science & Technology

Thiourea-Catalyzed Addition of Indoles to Aliphatic β,γ-Unsaturated α-Ketoesters

(2015) Verónica Juste-Navarro et al.   Asian Journal of Organic Chemistry

Asymmetric Synthesis of Bioxindole-Substituted Hexahydrofuro[2,3-b]furansviaHydroquinine Anthraquinone-1,4-diyl Diether-Catalyzed Domino Annulation of Acylidenoxindoles/Isatins, Acylidenoxindoles and Allenoates

(2014) Hai-Bin Yang et al.   ADVANCED SYNTHESIS & CATALYSIS

CH Functionalization/Asymmetric Michael Addition Cascade Enabled by Relay Catalysis: Metal Carbenoid Used for CC Bond Formation

(2014) Dian-Feng Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Asymmetric Arylative Dearomatization of 2,3-Disubstituted Indoles Enabled by Tandem Reactions

(2014) Yu-Chen Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of chiral benzene-based tetraoxazolines and their application in asymmetric Friedel–Crafts alkylation of indole derivatives with nitroalkenes

(2014) Wei-Jie Li   CATALYSIS COMMUNICATIONS

Enantioselective N-alkylation of isatins and synthesis of chiral N-alkylated indoles

(2014) Xiaowei Dou et al.   CHEMICAL COMMUNICATIONS

Chiral phosphoramide-catalyzed enantioselective synthesis of 2,3′-diindolylarylmethanes from indol-2-yl carbinols and indoles

(2014) Shuai Qi et al.   CHEMICAL COMMUNICATIONS

Enantioselective Copper(I/II)-Catalyzed Conjugate Addition of Nitro Esters to β,γ-Unsaturated α-Ketoesters

(2014) Sheng Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Imidazoline-Aminophenol (IAP) Nickel Catalyst: Structure and Catalytic Activity in the Enantioselective 1,4-Addition of 3′-Indolyl-3-Oxindoles to Nitroethylene

(2014) Atsuko Awata et al.   CHEMISTRY-A EUROPEAN JOURNAL

“On water” expedient synthesis of 3-indolyl-3-hydroxy oxindole derivatives and their anticancer activity in vitro

(2014) Parvathaneni Sai Prathima et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric Friedel–Crafts Reactions of N-tert-Butylsulfinyl-3,3,3-trifluoroacetaldimines: General Access to Enantiomerically Pure Indoles Containing a 1-Amino-2,2,2-trifluoroethyl Group

(2014) Lingmin Wu et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalyzed Asymmetric Aldol Reactions of Ketones and β,γ-Unsaturated α-Ketoesters and Phenylglyoxal Hydrates

(2014) Swapna Konda et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric organocatalytic synthesis of 4,6-bis(1H-indole-3-yl)-piperidine-2 carboxylates

(2014) Sabilla Zhong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly enantioselective reaction of 2-oxindoles with (3-indolyl)methanols by cooperative Catalysis of a Lewis acid and organocatalyst

(2014) Chuan-Li Ren et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-Catalyzed Enantioselective Hetero-Diels–Alder Reaction of Danishefsky’s Diene with β,γ-Unsaturated α-Ketoesters

(2014) Yanbin Hu et al.   ORGANIC LETTERS

Dinuclear zinc catalyzed asymmetric tandem Michael addition/acetalization reactions of cyclic diketones and β,γ-unsaturated α-ketoesters

(2014) Xixi Song et al.   TETRAHEDRON

Asymmetric synthesis of 3-substituted indole derivatives containing tetrahydrothiophene via cascade sulfa-Michael/Michael additions catalyzed by a chiral squaramide catalyst

(2014) Ying-He Li et al.   TETRAHEDRON-ASYMMETRY

Enantioselective Friedel–Crafts alkylation of indoles with β,γ-unsaturated α-ketoesters catalyzed by new squaramide-linked bisoxazoline–Zn(OTf)2 complexes

(2014) Sheng-Jian Jia et al.   TETRAHEDRON-ASYMMETRY

Asymmetric Michael/hemiketalization of 5-hydroxy-2-methyl-4H-pyran-4-one to β,γ-unsaturated α-ketoesters catalyzed by a bifunctional rosin–indane amine thiourea catalyst

(2014) B. V. Subba Reddy et al.   RSC Advances

Recent Advances in Asymmetric Organocatalytic Construction of 3,3′-Spirocyclic Oxindoles

(2013) Liang Hong et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Pyrroloindolones by N-Heterocyclic Carbene Catalyzed [2+3] Annulation of α-Chloroaldehydes with Nitrovinylindoles

(2013) Qijian Ni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Synthesis of Mixed 3,3′-Bisindoles and Their Evaluation as Wnt Signaling Inhibitors

(2013) Takayoshi Arai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gold-Catalyzed Intramolecular Regio- and Enantioselective Cycloisomerization of 1,1-Bis(indolyl)-5-alkynes

(2013) Long Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective Friedel-Crafts Alkylation/N-Hemiacetalization Cascade Reaction with Indoles

(2013) Hong-Gang Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Friedel–Crafts alkylation for synthesis of 2-substituted indole derivatives

(2013) Yulong Zhang et al.   CHEMICAL COMMUNICATIONS

Substituted (E)-2-Oxo-3-butenoates: Reagents for Every Enantioselectively-Catalyzed Reaction

(2013) Giovanni Desimoni et al.   CHEMICAL REVIEWS

An Unusual Triphenylphosphine Oxide Catalyzed Stereoselective 1,3-Dichlorination of Unsaturated Ketoesters

(2013) Tian-Yang Yu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Organocatalytic Construction of Hexahydropyrroloindole by Means of α-Alkylation of Aldehydes Leading to the Total Synthesis of (+)-Gliocladin C

(2013) Jin Song et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective Construction of Trifluoromethylated All-Carbon Quaternary Stereocenters via Nickel-Catalyzed Friedel–Crafts Alkylation Reaction

(2013) Jian-Rong Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective inhibition of reverse transcriptase (RT) of HIV-1 by non-racemic indole-based trifluoropropanoates developed by asymmetric catalysis using recyclable organocatalysts

(2013) Xin Han et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Efficient Enantioselective Synthesis of Dihydropyrans Using a Chiral N,N′-Dioxide as Organocatalyst

(2013) Juhua Feng et al.   ORGANIC LETTERS

Organocatalytic Michael Addition of Indoles to Isatylidene-3-acetaldehydes: Application to the Formal Total Synthesis of (−)-Chimonanthine

(2013) Renrong Liu et al.   ORGANIC LETTERS

Highly enantioselective Friedel–Crafts alkylation of indoles with α,β-unsaturated ketones with simple Cu(II)–oxazoline–imidazoline catalysts

(2013) Assem Barakat et al.   TETRAHEDRON

The Direct Asymmetric α Alkylation of Ketones by Brønsted Acid Catalysis

(2012) Liu Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic asymmetric Michael addition of unprotected 3-substituted oxindoles to 1,4-naphthoquinone

(2012) Jin-Sheng Yu et al.   Beilstein Journal of Organic Chemistry

Highly enantioselective Friedel–Crafts alkylation of indoles and pyrrole with β,γ-unsaturated α-ketoesters catalyzed by heteroarylidene-tethered bis(oxazoline) copper complexes

(2012) Lei Liu et al.   CHEMICAL COMMUNICATIONS

The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids

(2012) Jingchao Feng et al.   CHEMICAL COMMUNICATIONS

Indoles in Multicomponent Processes (MCPs)

(2012) Morteza Shiri   CHEMICAL REVIEWS

Facile synthesis of highly functional pyrrolizidine derivatives from β,γ-unsaturated α-keto esters and proline via a tandem cycloaddition

(2012) Tai-Ran Kang et al.   TETRAHEDRON LETTERS

ChiralN,N′-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions

(2011) XiaoHua Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Asymmetric Binary Acid Catalysis: A Regioselectivity Switch between Enantioselective 1,2- and 1,4-Addition through Different Counteranions of InIII

(2011) Jian Lv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Core-Structure-Oriented Asymmetric Organocatalytic Substitution of 3-Hydroxyoxindoles: Application in the Enantioselective Total Synthesis of (+)-Folicanthine

(2011) Chang Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploiting the Electrophilic Properties of Indole Intermediates: New Options in Designing Asymmetric Reactions

(2011) Charles C. J. Loh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Palladium Catalyzed Asymmetric Addition of Oxindoles and Allenes: An Atom-Economical Versatile Method for the Construction of Chiral Indole Alkaloids

(2011) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Total Synthesis of (+)-Gliocladine C: Convergent Construction of Cyclotryptamine-Fused Polyoxopiperazines and a General Approach for Preparing Epidithiodioxopiperazines from Trioxopiperazine Precursors

(2011) John E. DeLorbe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphonium ion tagged chiral phosphoric acids and their application in Friedel–Crafts reactions of indoles

(2011) Julia Hermeke et al.   TETRAHEDRON

Highly enantioselective Friedel–Crafts alkylation of indole and pyrrole with β,γ-unsaturated α-ketoester catalyzed by chiral dicationic palladium complex

(2011) Kohsuke Aikawa et al.   TETRAHEDRON LETTERS

Development of Diphenylamine-Linked Bis(imidazoline) Ligands and Their Application in Asymmetric Friedel-Crafts Alkylation of Indole Derivatives with Nitroalkenes

(2010) Han Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and Anxiety

(2010) Anna J. Kochanowska-Karamyan et al.   CHEMICAL REVIEWS

Asymmetric Addition of Indoles to Isatins Catalysed by Bifunctional Modified Cinchona Alkaloid Catalysts

(2010) Pankaj Chauhan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria

(2010) Bryan K. S. Yeung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chiral Brønsted acid catalyzed asymmetric Friedel–Crafts alkylation reaction of indoles with α,β-unsaturated ketones: short access to optically active 2- and 3-substituted indole derivatives

(2010) Tsubasa Sakamoto et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Binary-Acid Catalysis with Chiral Phosphoric Acid and MgF2: Catalytic Enantioselective Friedel−Crafts Reactions of β,γ-Unsaturated α-Ketoesters

(2010) Jian Lv et al.   ORGANIC LETTERS

Catalytic Functionalization of Indoles in a New Dimension

(2009) Marco Bandini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Brønsted acid catalyzed Friedel–Crafts alkylation reactions

(2009) Shu-Li You et al.   CHEMICAL SOCIETY REVIEWS

AgAsF6/Sm(OTf)3Promoted Reversal of Enantioselectivity for the Asymmetric Friedel−Crafts Alkylations of Indoles with β,γ-Unsaturated α-Ketoesters

(2009) Yanling Liu et al.   ORGANIC LETTERS

Monoalkylation of primary amines and N-sulfinylamides

(2008) José Luis García Ruano et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric Friedel−Crafts Alkylation ReactionsCopper Showed the Way

(2008) Thomas B. Poulsen et al.   CHEMICAL REVIEWS

Asymmetric Friedel–Crafts Alkylation of Indoles with Methyl (E)-2-Oxo-4-aryl-3-butenoates Catalyzed by Sc(OTf)3/pybox

(2008) Giovanni Desimoni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Friedel–Crafts Alkylation of Electron‐Rich N‐Heterocycles with Nitroalkenes Catalyzed by Diphenylamine‐Tethered Bis(oxazoline) and Bis(thiazoline) ZnIIComplexes

(2008) Han Liu et al.   Chemistry-An Asian Journal

Asymmetric Brønsted Acid Catalysis: Enantioselective Nucleophilic Substitutions and 1,4-Additions

(2007) Magnus Rueping et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Synthesis of Secondary and Tertiary Amines by Cp*Iridium-Catalyzed Multialkylation of Ammonium Salts with Alcohols

(2007) Ryohei Yamaguchi et al.   ORGANIC LETTERS