Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 77, Pages 11354-11357Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc04586f
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Asymmetric N-alkylations of isatins with enals were shown to be feasible via a prolinol-catalyzed iminium activation, and N-alkylated isatins were obtained in good yields and with excellent enantio-selectivity. The biologically useful N-alkylated isatins also served as valuable synthetic precursors, and could be readily converted to chiral N-alkylated indole derivatives. The described method provides a novel entry to access optically enriched N-alkylated isatins and indole derivatives.
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