4.4 Article

Facile synthesis of highly functional pyrrolizidine derivatives from β,γ-unsaturated α-keto esters and proline via a tandem cycloaddition

Journal

TETRAHEDRON LETTERS
Volume 53, Issue 20, Pages 2552-2555

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.03.034

Keywords

Pyrrolizidine; Unsaturated keto ester; Cycloaddition; Facile synthesis

Funding

  1. NSFC [21102116]
  2. Department of Education, Sichuan Province [10ZB016]
  3. China West Normal University [10B003, 11B004]

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A new tandem cycloaddition between proline and beta,gamma-unsaturated alpha-keto esters was disclosed. Highly functional and diastereomerically pure pyrrolizidine derivatives were obtained in moderate to high yields. (C) 2012 Elsevier Ltd. All rights reserved.

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