Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology

Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1

(2012) Stefanie Grimm et al.   BIOCHEMICAL JOURNAL

Can the beneficial effects of methionine restriction in rats be explained in part by decreased methylglyoxal generation resulting from suppressed carbohydrate metabolism?

(2012) Alan R. Hipkiss   BIOGERONTOLOGY

The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor

(2012) Armando Rojas et al.   CELLULAR SIGNALLING

A study on serum advanced glycation end products and its association with oxidative stress and paraoxonase activity in type 2 diabetic patients with vascular complications

(2012) Savita Bansal et al.   CLINICAL BIOCHEMISTRY

CD36 as a Therapeutic Target for Endothelial Dysfunction in Stroke

(2012) Sunghee Cho   CURRENT PHARMACEUTICAL DESIGN

Cathepsins D and L reduce the toxicity of advanced glycation end products

(2012) Stefanie Grimm et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibitory effect of alternatively spliced RAGEv1 on the expression of NF-kB and TNF-α in hepatocellular carcinoma cells

(2012) T. Lertwittayapon et al.   GENETICS AND MOLECULAR RESEARCH

Molecular Basis of Arterial Stiffening: Role of Glycation – A Mini-Review

(2012) David R. Sell et al.   GERONTOLOGY

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Advanced glycation end products and neurodegenerative diseases: Mechanisms and perspective

(2012) Jinlong Li et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Effect of Benfotiamine on Advanced Glycation Endproducts and Markers of Endothelial Dysfunction and Inflammation in Diabetic Nephropathy

(2012) Alaa Alkhalaf et al.   PLoS One

Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1

(2012) W. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycer-AGEs-RAGE signaling enhances the angiogenic potential of hepatocellular carcinoma by upregulating VEGF expression

(2012) Junichi Takino   WORLD JOURNAL OF GASTROENTEROLOGY

Amyloid Beta Induces Oxidative Stress-Mediated Blood–Brain Barrier Changes in Capillary Amyloid Angiopathy

(2011) Anna Carrano et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of autophagy in genetic pathways influencing ageing

(2011) Maria Markaki et al.   BIOGERONTOLOGY

Biogerontology: from here to where? The Lord Cohen Medal Lecture-2011

(2011) Suresh I. S. Rattan   BIOGERONTOLOGY

Selective autophagy in the maintenance of cellular homeostasis in aging organisms

(2011) Vanessa M. Hubbard et al.   BIOGERONTOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Ghrelin inhibits AGEs-induced apoptosis in human endothelial cells involving ERK1/2 and PI3K/Akt pathways

(2011) Ying Xiang et al.   CELL BIOCHEMISTRY AND FUNCTION

Moderate glycation of serum albumin affects folding, stability, and ligand binding

(2011) Stefan W. Vetter et al.   CLINICA CHIMICA ACTA

Dietary intake associated with serum versus urinary carboxymethyl-lysine, a major advanced glycation end product, in adults: the Energetics Study

(2011) R D Semba et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet

(2011) Stephanie Seneff et al.   European Journal of Internal Medicine

Urinary biomarkers of oxidative/nitrosative stress in healthy smokers

(2011) Carlos Campos et al.   INHALATION TOXICOLOGY

Advanced glycation end products enhance reactive oxygen and nitrogen species generation in neutrophils in vitro

(2011) Savita Bansal et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease

(2011) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding

(2011) Masakiyo Sakaguchi et al.   PLoS One

Biomarkers of aging in Drosophila

(2010) Jake Jacobson et al.   AGING CELL

Health effects of dietary Maillard reaction products: the results of ICARE and other studies

(2010) Frédéric J. Tessier et al.   AMINO ACIDS

Increased concentration of two different advanced glycation end-products detected by enzyme immunoassays with new monoclonal antibodies in sera of patients with rheumatoid arthritis

(2010) Richard Vytášek et al.   BMC MUSCULOSKELETAL DISORDERS

Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse

(2010) Nina Reiniger et al.   DIABETES

Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes

(2010) N. Karachalias et al.   DIABETOLOGIA

Clinical impact of glycated albumin as another glycemic control marker

(2010) Masafumi Koga et al.   ENDOCRINE JOURNAL

Vascular and Cardiac Impairments in Rats Inhaling Ozone and Diesel Exhaust Particles

(2010) Urmila P. Kodavanti et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes

(2010) Sho-ichi Yamagishi   EXPERIMENTAL GERONTOLOGY

Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins

(2010) Stefanie Grimm et al.   FREE RADICAL RESEARCH

Infusion fluids contain harmful glucose degradation products

(2010) Anna Bryland et al.   INTENSIVE CARE MEDICINE

Inflammation, Cytokines, Immune Response, Apolipoprotein E, Cholesterol, and Oxidative Stress in Alzheimer Disease: Therapeutic Implications

(2010) Giuseppina Candore et al.   REJUVENATION RESEARCH

Advanced Glycation End Product Receptor-1 Transgenic Mice Are Resistant to Inflammation, Oxidative Stress, and Post-Injury Intimal Hyperplasia

(2009) Massimo Torreggiani et al.   AMERICAN JOURNAL OF PATHOLOGY

AGEs increased migration and inflammatory responses of adventitial fibroblasts via RAGE, MAPK and NF-κB pathways

(2009) YaYang Liu et al.   ATHEROSCLEROSIS

Fueling inflammation at tumor microenvironment: the role of multiligand/rage axis

(2009) A. Rojas et al.   CARCINOGENESIS

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

The receptor RAGE: Bridging inflammation and cancer

(2009) Astrid Riehl et al.   Cell Communication and Signaling

The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival

(2009) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study

(2009) Richard D. Semba et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Soluble forms of RAGE in internal medicine

(2009) Natale Vazzana et al.   Internal and Emergency Medicine

Astragalosides Isolated from the Root of Astragalus Radix Inhibit the Formation of Advanced Glycation End Products

(2009) Keita Motomura et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Regulation of alternative splicing of the receptor for advanced glycation endproducts (RAGE) through G-rich cis-elements and heterogenous nuclear ribonucleoprotein H

(2009) Kazuyo Ohe et al.   JOURNAL OF BIOCHEMISTRY

RAGE-Induced Cytosolic ROS Promote Mitochondrial Superoxide Generation in Diabetes

(2009) M. T. Coughlan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation

(2009) Louis J Sparvero et al.   Journal of Translational Medicine

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

(2009) Velandai Srikanth et al.   NEUROBIOLOGY OF AGING

Deletion of RAGE Causes Hyperactivity and Increased Sensitivity to Auditory Stimuli in Mice

(2009) Seiichi Sakatani et al.   PLoS One

Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors

(2009) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Determination of N ɛ-(carboxymethyl)lysine in food systems by ultra performance liquid chromatography-mass spectrometry

(2008) Shima H. Assar et al.   AMINO ACIDS

Plasma Concentration and Urinary Excretion of Nɛ-(Carboxymethyl)lysine in Breast Milk- and Formula-fed Infants

(2008) Katarína Šebeková et al.   Annals of the New York Academy of Sciences

Effect of advanced glycation endproducts on gene expression profiles of human dermal fibroblasts

(2008) J. Molinari et al.   BIOGERONTOLOGY

Increased molecular damage and heterogeneity as the basis of aging

(2008) Suresh I.S. Rattan   BIOLOGICAL CHEMISTRY

The pyridoxamine action on Amadori compounds: A reexamination of its scavenging capacity and chelating effect

(2008) Miquel Adrover et al.   BIOORGANIC & MEDICINAL CHEMISTRY

RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis

(2008) Olga Turovskaya et al.   CARCINOGENESIS

A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)

(2008) Angela Raucci et al.   FASEB JOURNAL

RAGE signaling sustains inflammation and promotes tumor development

(2008) Christoffer Gebhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation

(2007) Weijing Cai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Receptor for advanced glycation endproducts and atherosclerosis: From basic mechanisms to clinical implications

(2007) Giuseppina Basta   ATHEROSCLEROSIS