The Emerging Role of TYRO3 as a Therapeutic Target in Cancer

Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma

(2018) Hirokazu Sadahiro et al.   CANCER RESEARCH

Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response

(2018) Eric Ubil et al.   JOURNAL OF CLINICAL INVESTIGATION

Abstract 2488: Functional characterization of nuclear TYRO3 in colorectal cancer

(2018) Shaw-Jenq Tsai et al.   CANCER RESEARCH

MicroRNA-7 inhibits colorectal cancer cell proliferation, migration and invasion via TYRO3 and phosphoinositide 3-kinase/protein B kinase/mammalian target of rapamycin pathway suppression

(2018) Ancheng Qin et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group

(2018) Jichen Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

The TAM receptor Tyro3 regulates myelination in the central nervous system

(2017) Rainer Akkermann et al.   GLIA

Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

(2017) Peter P. Ruvolo et al.   HAEMATOLOGICA

A microRNA-7/growth arrest specific 6/TYRO3 axis regulates the growth and invasiveness of sorafenib-resistant cells in human hepatocellular carcinoma

(2017) Tasnuva D. Kabir et al.   HEPATOLOGY

Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression

(2017) Canan Kasikara et al.   MOLECULAR CANCER RESEARCH

Cell signalling pathway regulation by RanBPM: molecular insights and disease implications

(2017) Louisa M. Salemi et al.   Open Biology

Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

(2017) Peter P. Ruvolo et al.   HAEMATOLOGICA

The prognostic correlation of AFP level at diagnosis with pathological grade, progression, and survival of patients with hepatocellular carcinoma

(2017) Dou-Sheng Bai et al.   Scientific Reports

Abstract 1265: Dysregulated tyrosine kinase Tyro3 signaling in acute myeloid leukemia

(2016) Fatma Eryildiz et al.   CANCER RESEARCH

RXDX-106 Is an orally-available, potent and selective TAM/MET inhibitor demonstrating preclinical efficacy in MET-dependent human malignancies

(2016) A. Franovic et al.   EUROPEAN JOURNAL OF CANCER

Hetero-interaction amongst Tyro3 and Axl receptor tyrosine kinases diversifies cancer signalling

(2016) M. Vouri et al.   EUROPEAN JOURNAL OF CANCER

Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer

(2016) Peter B. Alexander et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of TYRO3/Akt signaling participates in hypoxic injury in hippocampal neurons

(2016) Yan-zhen Zhu et al.   Neural Regeneration Research

Targeting TYRO3 inhibits epithelial–mesenchymal transition and increases drug sensitivity in colon cancer

(2016) C-W Chien et al.   ONCOGENE

The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity

(2016) P. Y. Chan et al.   SCIENCE

Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors

(2016) Xiaodong Wang et al.   ACS Medicinal Chemistry Letters

TAM receptors Tyro3 and Mer as novel targets in colorectal cancer

(2016) Robin Schmitz et al.   Oncotarget

Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response

(2016) Viralkumar Davra et al.   Cancers

TAM Receptor Signaling in Immune Homeostasis

(2015) Carla V. Rothlin et al.   Annual Review of Immunology

Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors

(2015) S. Sinha et al.   CLINICAL CANCER RESEARCH

Metformin targets Axl and Tyro3 receptor tyrosine kinases to inhibit cell proliferation and overcome chemoresistance in ovarian cancer cells

(2015) NAM-YI KIM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Overexpression of Tyro3 and its implications on hepatocellular carcinoma progression

(2015) YAN DUAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination

(2015) Yuki Miyamoto et al.   MOLECULAR BIOLOGY OF THE CELL

The Role and Regulation of Osteoclasts in Normal Bone Homeostasis and in Response to Injury

(2015) Adrian McArdle et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia

(2015) Alisa B. Lee-Sherick et al.   Oncotarget

Significant blockade of multiple receptor tyrosine kinases by MGCD516 (Sitravatinib), a novel small molecule inhibitor, shows potent anti-tumor activity in preclinical models of sarcoma

(2015) Parag P. Patwardhan et al.   Oncotarget

Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian cancer cells

(2015) CHUHEE LEE   Molecular Medicine Reports

TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis

(2014) J. H. M. van der Meer et al.   BLOOD

The Role of Snail in EMT and Tumorigenesis

(2014) Yifan Wang et al.   CURRENT CANCER DRUG TARGETS

Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells

(2014) YOUNG-AH SUH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

(2014) Wen-I Tsou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor

(2014) Weihe Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

(2014) Magdalena Paolino et al.   NATURE

Deletion of the receptor tyrosine kinase Tyro3 inhibits synovial hyperplasia and bone damage in arthritis

(2013) Gisela Ruiz-Heiland et al.   ANNALS OF THE RHEUMATIC DISEASES

Evaluation of Tyro3 Expression, Gas6-Mediated Akt Phosphorylation, and the Impact of Anti-Tyro3 Antibodies in Melanoma Cell Lines

(2013) Stephen J. Demarest et al.   BIOCHEMISTRY

TAM receptor tyrosine kinases: Expression, disease and oncogenesis in the central nervous system

(2013) Angela M. Pierce et al.   BRAIN RESEARCH

Protein S: A multifunctional anticoagulant vitamin K-dependent protein at the crossroads of coagulation, inflammation, angiogenesis, and cancer

(2013) Lutfi Suleiman et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

UNC1062, a new and potent Mer inhibitor

(2013) Jing Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

MERTK receptor tyrosine kinase is a therapeutic target in melanoma

(2013) Jennifer Schlegel et al.   JOURNAL OF CLINICAL INVESTIGATION

Whole-exome sequencing of pancreatic neoplasms with acinar differentiation

(2013) Yuchen Jiao et al.   JOURNAL OF PATHOLOGY

UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic LeukemiaIn VitroandIn Vivo

(2013) Sandra Christoph et al.   MOLECULAR CANCER THERAPEUTICS

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival

(2013) S Ammoun et al.   ONCOGENE

GAS6 Receptor Status Is Associated with Dormancy and Bone Metastatic Tumor Formation

(2013) Russell S. Taichman et al.   PLoS One

Autocrine role for Gas6 with Tyro3 and Axl in leiomyosarcomas

(2013) Hiba el Sayadi et al.   Targeted Oncology

Biological Function of Nuclear Receptor Tyrosine Kinase Action

(2013) S. Song et al.   Cold Spring Harbor Perspectives in Biology

Biology of the TAM Receptors

(2013) G. Lemke   Cold Spring Harbor Perspectives in Biology

MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

(2013) N. Wagle et al.   Cancer Discovery

Upregulation of anticoagulant proteins, protein S and tissue factor pathway inhibitor, in the mouse myocardium with cardio-specific TNF-α overexpression

(2012) Yoshihiro Higuchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

(2012) Noel A. Powell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

(2012) Noel A. Powell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models

(2012) S. Betty Yan et al.   INVESTIGATIONAL NEW DRUGS

Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons

(2012) Prashant Kumar Modi et al.   MOLECULAR BIOLOGY OF THE CELL

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer

(2012) R M A Linger et al.   ONCOGENE

Cross-Phosphorylation, Signaling and Proliferative Functions of the Tyro3 and Axl Receptors in Rat2 Cells

(2012) Jessica E. Brown et al.   PLoS One

Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia

(2012) Jing Liu et al.   ACS Medicinal Chemistry Letters

Novel and selective spiroindoline-based inhibitors of sky kinase

(2011) Noel A. Powell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation of TYRO3/AXL Tyrosine Kinase Receptors in Thyroid Cancer

(2011) E. Avilla et al.   CANCER RESEARCH

Macrophage–tumor crosstalk: role of TAMR tyrosine kinase receptors and of their ligands

(2011) Thomas Schmidt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Type 2 innate immune responses and the natural helper cell

(2011) Shigeo Koyasu et al.   IMMUNOLOGY

Galectin-3 is a new MerTK-specific eat-me signal

(2011) Nora B. Caberoy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Human Cutaneous Melanomas Lacking MITF and Melanocyte Differentiation Antigens Express a Functional Axl Receptor Kinase

(2011) Marialuisa Sensi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Profiling of Antibody Production against Xenograft-released Proteins by Protein Microarrays Discovers Prostate Cancer Markers

(2011) Flip H. Jansen et al.   JOURNAL OF PROTEOME RESEARCH

Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null mice

(2011) Angela Pierce et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Phosphoproteomic Screen Identifies Potential Therapeutic Targets in Melanoma

(2011) K. Tworkoski et al.   MOLECULAR CANCER RESEARCH

Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway

(2011) Huang Guo et al.   Molecular Neurodegeneration

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Receptor tyrosine kinases and their activation in melanoma

(2011) David J. Easty et al.   Pigment Cell & Melanoma Research

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor

(2010) D. Zhu et al.   BLOOD

Autoimmunity and the Clearance of Dead Cells

(2010) Shigekazu Nagata et al.   CELL

A systems view of epithelial–mesenchymal transition signaling states

(2010) Stuart Thomson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis

(2010) Nora B Caberoy et al.   EMBO JOURNAL

Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors

(2010) Rachel MA Linger et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Protein S Protects Neurons from Excitotoxic Injury by Activating the TAM Receptor Tyro3-Phosphatidylinositol 3-Kinase-Akt Pathway through Its Sex Hormone-Binding Globulin-Like Region

(2010) Z. Zhong et al.   JOURNAL OF NEUROSCIENCE

The CXCR4/SDF-1 Chemokine Receptor Axis: A New Target Therapeutic for Non-small Cell Lung Cancer

(2010) Shannon Otsuka et al.   Journal of Thoracic Oncology

Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization

(2010) J. M. E. M. COSEMANS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma

(2010) S. Ammoun et al.   NEURO-ONCOLOGY

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6

(2009) S. Loges et al.   BLOOD

Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL

(2009) L. Liu et al.   CANCER RESEARCH

GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche

(2009) Yusuke Shiozawa et al.   EXPERIMENTAL HEMATOLOGY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery ofN-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

(2009) Gretchen M. Schroeder et al.   JOURNAL OF MEDICINAL CHEMISTRY

A genomic screen identifies TYRO3 as a MITF regulator in melanoma

(2009) S. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NGF-induced Tyro3 and Axl function as survival factors for differentiating PC12 cells

(2008) Yan Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

(2008) M. M. Loriaux et al.   BLOOD

AXL Is a Potential Target for Therapeutic Intervention in Breast Cancer Progression

(2008) Y.-X. Zhang et al.   CANCER RESEARCH

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

(2008) Xudong Huang et al.   JOURNAL OF STRUCTURAL BIOLOGY

Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

(2008) L L Remsing Rix et al.   LEUKEMIA

Axl and Tyro3 Modulate Female Reproduction by Influencing Gonadotropin-Releasing Hormone Neuron Survival and Migration

(2008) Angela Pierce et al.   MOLECULAR ENDOCRINOLOGY

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE