A microRNA-7/growth arrest specific 6/TYRO3 axis regulates the growth and invasiveness of sorafenib-resistant cells in human hepatocellular carcinoma

Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Jordi Bruix et al.   LANCET

Targeting Therapeutic Oligonucleotides

(2017) Arthur A. Levin   NEW ENGLAND JOURNAL OF MEDICINE

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9

(2017) Kevin Fitzgerald et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol

(2017) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting TYRO3 inhibits epithelial–mesenchymal transition and increases drug sensitivity in colon cancer

(2016) C-W Chien et al.   ONCOGENE

microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NF-κB

(2016) Keith M. Giles et al.   Oncotarget

Sorafenib-resistant hepatocellular carcinoma stratified by phosphorylated ERK activates PD-1 immune checkpoint

(2016) Jiang Chen et al.   Oncotarget

Axl Expression Stratifies Patients with Poor Prognosis after Hepatectomy for Hepatocellular Carcinoma

(2016) Jian Liu et al.   PLoS One

miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGγ

(2015) Yuan Shi et al.   CANCER LETTERS

Activated hepatic stellate cells promote angiogenesis via interleukin-8 in hepatocellular carcinoma

(2015) Bing Zhu et al.   Journal of Translational Medicine

MK2206 overcomes the resistance of human liver cancer stem cells to sorafenib by inhibition of pAkt and upregulation of pERK

(2015) Beibei Zhai et al.   TUMOR BIOLOGY

Radiofrequency ablation-increased CXCL10 is associated with earlier recurrence of hepatocellular carcinoma by promoting stemness

(2015) Yabo Ouyang et al.   TUMOR BIOLOGY

First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway

(2015) M. Hagel et al.   Cancer Discovery

Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian cancer cells

(2015) CHUHEE LEE   Molecular Medicine Reports

TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis

(2014) J. H. M. van der Meer et al.   BLOOD

microRNA-7: A tumor suppressor miRNA with therapeutic potential

(2014) Felicity C. Kalinowski et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

(2014) Wen-I Tsou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Benzylidene-indolinones are effective as multi-targeted kinase inhibitor therapeutics against hepatocellular carcinoma

(2014) Han Kiat Ho et al.   Molecular Oncology

MicroRNA-7 arrests cell cycle in G1 phase by directly targeting CCNE1 in human hepatocellular carcinoma cells

(2013) Xiao Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evaluation of Tyro3 Expression, Gas6-Mediated Akt Phosphorylation, and the Impact of Anti-Tyro3 Antibodies in Melanoma Cell Lines

(2013) Stephen J. Demarest et al.   BIOCHEMISTRY

First Axl inhibitor enters clinical trials

(2013) Cormac Sheridan   NATURE BIOTECHNOLOGY

GAS6 Receptor Status Is Associated with Dormancy and Bone Metastatic Tumor Formation

(2013) Russell S. Taichman et al.   PLoS One

Pathways and targets in hepatocellular carcinoma

(2012) Amanda Psyrri et al.   Expert Review of Anticancer Therapy

MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma

(2012) YuXiang Fang et al.   HEPATOLOGY

Role of sorafenib in the treatment of advanced hepatocellular carcinoma: An update

(2012) Angela Gauthier et al.   HEPATOLOGY RESEARCH

EGFR activation is a potential determinant of primary resistance of hepatocellular carcinoma cells to sorafenib

(2012) Zakaria Ezzoukhry et al.   INTERNATIONAL JOURNAL OF CANCER

Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells

(2012) Marie-José Blivet-Van Eggelpoël et al.   JOURNAL OF HEPATOLOGY

Regulation of Epidermal Growth Factor Receptor Signaling and Erlotinib Sensitivity in Head and Neck Cancer Cells by miR-7

(2012) Felicity C. Kalinowski et al.   PLoS One

Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells

(2011) R. Gioia et al.   BLOOD

microRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling

(2011) Kyung Min Lee et al.   RADIOTHERAPY AND ONCOLOGY

The MicroRNA miR-139 Suppresses Metastasis and Progression of Hepatocellular Carcinoma by Down-regulating Rho-Kinase 2

(2010) Carmen Chak–Lui Wong et al.   GASTROENTEROLOGY

PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment

(2009) Yongping Crawford et al.   CANCER CELL

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells

(2008) Na Li et al.   CANCER LETTERS

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

(2008) B. Kefas et al.   CANCER RESEARCH