Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response

Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase

(2016) Stanley G. Kimani et al.   Cell Communication and Signaling

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer

(2016) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

Efferocytosis

(2016) Sushil Kumar et al.   CURRENT BIOLOGY

Antibody-mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumorsin vivo

(2016) Gordon Moody et al.   INTERNATIONAL JOURNAL OF CANCER

Development and characterization of a human microglia cell model of HIV-1 infection

(2016) Pratima Rawat et al.   JOURNAL OF NEUROVIROLOGY

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

(2016) Bishuang Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAM Receptor Signaling in Immune Homeostasis

(2015) Carla V. Rothlin et al.   Annual Review of Immunology

Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

(2015) Amanda Kirane et al.   CANCER RESEARCH

Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia

(2015) Alisa B. Lee-Sherick et al.   Oncotarget

Discovering Molecules That Regulate Efferocytosis Using Primary Human Macrophages and High Content Imaging

(2015) Sandra Santulli-Marotto et al.   PLoS One

MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme

(2015) Kristina H. Knubel et al.   Oncotarget

Axl as a mediator of cellular growth and survival

(2015) Haley Axelrod et al.   Oncotarget

Increased Exposure of Phosphatidylethanolamine on the Surface of Tumor Vascular Endothelium

(2015) Jason H. Stafford et al.   NEOPLASIA

AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs

(2014) C. Wilson et al.   CANCER RESEARCH

Cleavage of Mer Tyrosine Kinase (MerTK) from the Cell Surface Contributes to the Regulation of Retinal Phagocytosis

(2014) Ah-Lai Law et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

(2014) Wen-I Tsou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efferocytosis produces a prometastatic landscape during postpartum mammary gland involution

(2014) Jamie C. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor

(2014) Weihe Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

(2014) Magdalena Paolino et al.   NATURE

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis

(2014) Mihalis S Kariolis et al.   Nature Chemical Biology

Diversification of TAM receptor tyrosine kinase function

(2014) Anna Zagórska et al.   NATURE IMMUNOLOGY

Liver-Specific γ-Glutamyl Carboxylase-Deficient Mice Display Bleeding Diathesis and Short Life Span

(2014) Kotaro Azuma et al.   PLoS One

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET

(2014) Erinn B. Rankin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

(2014) Erin D Lew et al.   eLife

Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and Autoimmunity

(2014) Stanley Gititu Kimani et al.   Frontiers in Immunology

Gas6 gains entry into the coagulation cascade

(2013) J. H. Foley et al.   BLOOD

Inhibitory role of Gas6 in intestinal tumorigenesis

(2013) Reiko Akitake-Kawano et al.   CARCINOGENESIS

T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response

(2013) Eugenio A. Carrera Silva et al.   IMMUNITY

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

(2013) Rebecca S. Cook et al.   JOURNAL OF CLINICAL INVESTIGATION

MERTK receptor tyrosine kinase is a therapeutic target in melanoma

(2013) Jennifer Schlegel et al.   JOURNAL OF CLINICAL INVESTIGATION

UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic LeukemiaIn VitroandIn Vivo

(2013) Sandra Christoph et al.   MOLECULAR CANCER THERAPEUTICS

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Highly Specific PET Imaging of Prostate Tumors in Mice with an Iodine-124-Labeled Antibody Fragment That Targets Phosphatidylserine

(2013) Jason H. Stafford et al.   PLoS One

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer

(2013) L. Bosurgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology of the TAM Receptors

(2013) G. Lemke   Cold Spring Harbor Perspectives in Biology

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

Vascular Gas6 contributes to thrombogenesis and promotes tissue factor up-regulation after vessel injury in mice

(2012) R. S. Robins et al.   BLOOD

Inhibitors of the TAM subfamily of tyrosine kinases: Synthesis and biological evaluation

(2012) Rosa M. Suárez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

MET: a promising anticancer therapeutic target

(2012) Solange Peters et al.   Nature Reviews Clinical Oncology

Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer

(2012) R M A Linger et al.   ONCOGENE

Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA

(2011) Mark Mackiewicz et al.   BREAST CANCER RESEARCH AND TREATMENT

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

(2011) Edward Thorp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-3 is a new MerTK-specific eat-me signal

(2011) Nora B. Caberoy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer

(2011) G Mudduluru et al.   ONCOGENE

Differentiation and Glucocorticoid Regulated Apopto-Phagocytic Gene Expression Patterns in Human Macrophages. Role of Mertk in Enhanced Phagocytosis

(2011) Gábor Zahuczky et al.   PLoS One

Macrophages give Gas(6) to cancer

(2010) A. Sica   BLOOD

R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer

(2010) S. J. Holland et al.   CANCER RESEARCH

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis

(2010) Nora B Caberoy et al.   EMBO JOURNAL

Growth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury

(2010) Laura Llacuna et al.   HEPATOLOGY

Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization

(2010) J. M. E. M. COSEMANS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Up-Regulation of Soluble Axl and Mer Receptor Tyrosine Kinases Negatively Correlates with Gas6 in Established Multiple Sclerosis Lesions

(2009) Jason G. Weinger et al.   AMERICAN JOURNAL OF PATHOLOGY

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6

(2009) S. Loges et al.   BLOOD

Identification of tubby and tubby-like protein 1 as eat-me signals by phage display

(2009) Nora B. Caberoy et al.   EXPERIMENTAL CELL RESEARCH

TAM receptors and the regulation of erythropoiesis in mice

(2009) H. Tang et al.   HAEMATOLOGICA

Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages

(2009) A. McColl et al.   JOURNAL OF IMMUNOLOGY

Discovery ofN-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

(2009) Gretchen M. Schroeder et al.   JOURNAL OF MEDICINAL CHEMISTRY

Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

(2009) C. Gjerdrum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine

(2008) Isabelle Rajotte et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

(2008) I.-K. Park et al.   BLOOD

Axl and Growth Arrest Specific Gene 6 Are Frequently Overexpressed in Human Gliomas and Predict Poor Prognosis in Patients with Glioblastoma Multiforme

(2008) M. Hutterer et al.   CLINICAL CANCER RESEARCH

Role of thePROS1gene in thrombosis: lessons and controversies

(2008) Mary J Heeb   Expert Review of Hematology