Endothelial Atg7 Deficiency Ameliorates Acute Cerebral Injury Induced by Ischemia/Reperfusion

Autophagy in ischemic stroke

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Long non-coding RNAs in ischemic stroke

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Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFκB Pathway

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Atg7 Regulates Brain Angiogenesis via NF-κB-Dependent IL-6 Production

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Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood–brain barrier disruption after ischemic brain injury

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Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

(2016) Cuicui Xie et al.   Autophagy

Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells

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Mice deficient in endothelial α5 integrin are profoundly resistant to experimental ischemic stroke

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Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling

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YiQiFuMai Powder Injection ameliorates the oxygen-glucose deprivation-induced brain microvascular endothelial barrier dysfunction associated with the NF-κB and ROCK1/MLC signaling pathways

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Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity

(2016) Minshu Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diosgenin attenuates the brain injury induced by transient focal cerebral ischemia-reperfusion in rats

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Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

(2016) Yejie Shi et al.   Nature Communications

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

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Baicalein pretreatment reduces liver ischemia/reperfusion injury via induction of autophagy in rats

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Inflammatory Responses in Brain Ischemia

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Systemic inflammation as a therapeutic target in acute ischemic stroke

(2015) Tomasz Dziedzic   Expert Review of Neurotherapeutics

Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies

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Inhibition of p-IκBα Ubiquitylation by Autophagy-Related Gene 7 to Regulate Inflammatory Responses to Bacterial Infection

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Autophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level

(2015) Hui Wang et al.   MOLECULAR NEUROBIOLOGY

Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments

(2015) Paul M. George et al.   NEURON

The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia

(2015) Han Seok Koh et al.   Nature Communications

Systemic inflammation as a therapeutic target in acute ischemic stroke

(2015) Tomasz Dziedzic   Expert Review of Neurotherapeutics

The Neurotensin–HIF-1α–VEGFα Axis Orchestrates Hypoxia, Colonic Inflammation, and Intestinal Angiogenesis

(2014) Kyriaki Bakirtzi et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent

(2014) Michael J Morgan et al.   Autophagy

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

Brain endothelial cell specific integrins and ischemic stroke

(2014) Kathleen Guell et al.   Expert Review of Neurotherapeutics

The Essential Autophagy GeneATG7Modulates Organ Fibrosis via Regulation of Endothelial-to-Mesenchymal Transition

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Myeloid Knockout of HIF-1αDoes Not Markedly Affect Hemorrhage/Resuscitation-Induced Inflammation and Hepatic Injury

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Molecular dialogs between the ischemic brain and the peripheral immune system: Dualistic roles in injury and repair

(2014) Chengrui An et al.   PROGRESS IN NEUROBIOLOGY

Immune-inflammatory markers and arterial stiffness indexes in subjects with acute ischemic stroke with and without metabolic syndrome

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Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date

(2014) Antonino Tuttolomondo et al.   Drug Design Development and Therapy

Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke

(2014) Youngjeon Lee et al.   Biomed Research International

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Characterization of long-term functional outcome in a murine model of mild brain ischemia

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Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor

(2013) Takehiro Torisu et al.   NATURE MEDICINE

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Propofol Protects Against Focal Cerebral Ischemia via Inhibition of Microglia-Mediated Proinflammatory Cytokines in a Rat Model of Experimental Stroke

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Role of Inflammation and Its Mediators in Acute Ischemic Stroke

(2013) Rong Jin et al.   Journal of Cardiovascular Translational Research

Autophagy is required for the activation of NFκB

(2012) Alfredo Criollo et al.   CELL CYCLE

Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents

(2011) Boyeon Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Ischemia and reperfusion—from mechanism to translation

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Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Neuroprotection in stroke in the mouse with intravenous erythropoietin–Trojan horse fusion protein

(2010) Ailing Fu et al.   BRAIN RESEARCH

Calcium, ischemia and excitotoxicity

(2010) Kinga Szydlowska et al.   CELL CALCIUM

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Autophagy in Ischemic Heart Disease

(2009) Åsa B. Gustafsson et al.   CIRCULATION RESEARCH

IL-17 produced by neutrophils regulates IFN-γ–mediated neutrophil migration in mouse kidney ischemia-reperfusion injury

(2009) Li Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation as Therapeutic Objective in Stroke

(2008) Joaquin Jordan et al.   CURRENT PHARMACEUTICAL DESIGN

Hsp27 Protects against Ischemic Brain Injury via Attenuation of a Novel Stress-Response Cascade Upstream of Mitochondrial Cell Death Signaling

(2008) R. A. Stetler et al.   JOURNAL OF NEUROSCIENCE

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY