Review of the Amphibian Immune Response to Chytridiomycosis, and Future Directions

Frog's DCs have it all in one

(2018) Jacques Robert   EUROPEAN JOURNAL OF IMMUNOLOGY

“Double-duty” conventional dendritic cells in the amphibian Xenopus as the prototype for antigen presentation to B cells

(2018) Harold R. Neely et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Evolution of resistance to chytridiomycosis is associated with a robust early immune response

(2018) Laura F. Grogan et al.   MOLECULAR ECOLOGY

Distinct MHC class I-like interacting invariant T cell lineage at the forefront of mycobacterial immunity uncovered inXenopus

(2018) Eva-Stina Edholm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent Asian origin of chytrid fungi causing global amphibian declines

(2018) Simon J. O’Hanlon et al.   SCIENCE

Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation

(2018) Jamie Voyles et al.   SCIENCE

Pattern recognition receptors in fungal immunity

(2018) Emmanuel C. Patin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Amphibian chytridiomycosis outbreak dynamics are linked with host skin bacterial community structure

(2018) Kieran A. Bates et al.   Nature Communications

Chytridiomycosis causes catastrophic organism-wide metabolic dysregulation including profound failure of cellular energy pathways

(2018) Laura F. Grogan et al.   Scientific Reports

Gene expression differs in susceptible and resistant amphibians exposed to Batrachochytrium dendrobatidis

(2018) Evan A. Eskew et al.   Royal Society Open Science

Major histocompatibility complex variation and the evolution of resistance to amphibian chytridiomycosis

(2017) Minjie Fu et al.   IMMUNOGENETICS

Prodigiosin, Violacein, and Volatile Organic Compounds Produced by Widespread Cutaneous Bacteria of Amphibians Can Inhibit Two Batrachochytrium Fungal Pathogens

(2017) Douglas C. Woodhams et al.   MICROBIAL ECOLOGY

Greater Species Richness of Bacterial Skin Symbionts Better Suppresses the Amphibian Fungal Pathogen Batrachochytrium Dendrobatidis

(2017) Jonah Piovia-Scott et al.   MICROBIAL ECOLOGY

Are the adverse effects of stressors on amphibians mediated by their effects on stress hormones?

(2017) Caitlin R. Gabor et al.   OECOLOGIA

Transmission dynamics: critical questions and challenges

(2017) Janis Antonovics   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Estimating Herd Immunity to Amphibian Chytridiomycosis in Madagascar Based on the Defensive Function of Amphibian Skin Bacteria

(2017) Molly C. Bletz et al.   Frontiers in Microbiology

Epidermal cell death in frogs with chytridiomycosis

(2017) Laura A. Brannelly et al.   PeerJ

Chemotaxis of the amphibian pathogen Batrachochytrium dendrobatidis and its response to a variety of attractants

(2017) Angela S. Moss et al.   MYCOLOGIA

Skin sloughing in susceptible and resistant amphibians regulates infection with a fungal pathogen

(2017) Michel E. B. Ohmer et al.   Scientific Reports

Direct and Indirect Horizontal Transmission of the Antifungal Probiotic Bacterium Janthinobacterium lividum on Green Frog (Lithobates clamitans) Tadpoles

(2016) Eria A. Rebollar et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Major histocompatibility complex selection dynamics in pathogen-infected túngara frog (Physalaemus pustulosus) populations

(2016) Tiffany A. Kosch et al.   Biology Letters

Alpha-Ketoglutarate: Physiological Functions and Applications

(2016) Nan Wu et al.   Biomolecules & Therapeutics

Reservoir-host amplification of disease impact in an endangered amphibian

(2016) Ben C. Scheele et al.   CONSERVATION BIOLOGY

History and recent progress on chytridiomycosis in amphibians

(2016) Lee Berger et al.   Fungal Ecology

Evolution of innate-like T cells and their selection by MHC class I-like molecules

(2016) Eva-Stina Edholm et al.   IMMUNOGENETICS

Complement component C3 - The “Swiss Army Knife” of innate immunity and host defense

(2016) Daniel Ricklin et al.   IMMUNOLOGICAL REVIEWS

Skin bacterial diversity of Panamanian frogs is associated with host susceptibility and presence of Batrachochytrium dendrobatidis

(2016) Eria A Rebollar et al.   ISME Journal

Endemicity of chytridiomycosis features pathogen overdispersion

(2016) Laura F. Grogan et al.   JOURNAL OF ANIMAL ECOLOGY

High adult mortality in disease-challenged frog populations increases vulnerability to drought

(2016) Ben C. Scheele et al.   JOURNAL OF ANIMAL ECOLOGY

Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease

(2016) Danielle Pilla-Moffett et al.   JOURNAL OF MOLECULAR BIOLOGY

Comparative study of host response to chytridiomycosis in a susceptible and a resistant toad species

(2016) T. J. Poorten et al.   MOLECULAR ECOLOGY

Overview of chytrid emergence and impacts on amphibians

(2016) Karen R. Lips   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Adaptive tolerance to a pathogenic fungus drives major histocompatibility complex evolution in natural amphibian populations

(2016) Anna E. Savage et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Priorities for management of chytridiomycosis in Australia: saving frogs from extinction

(2016) Lee F. Skerratt et al.   WILDLIFE RESEARCH

Harnessing the Microbiome to Prevent Fungal Infections: Lessons from Amphibians

(2016) Jenifer B. Walke et al.   PLoS Pathogens

Using “Omics” and Integrated Multi-Omics Approaches to Guide Probiotic Selection to Mitigate Chytridiomycosis and Other Emerging Infectious Diseases

(2016) Eria A. Rebollar et al.   Frontiers in Microbiology

Chytrid infection and post-release fitness in the reintroduction of an endangered alpine tree frog

(2015) L. A. Brannelly et al.   ANIMAL CONSERVATION

Low impact of chytridiomycosis on frog recruitment enables persistence in refuges despite high adult mortality

(2015) Ben C. Scheele et al.   BIOLOGICAL CONSERVATION

Skin bacteria provide early protection for newly metamorphosed southern leopard frogs ( Rana sphenocephala ) against the frog-killing fungus, Batrachochytrium dendrobatidis

(2015) Whitney M. Holden et al.   BIOLOGICAL CONSERVATION

Effect of glucocorticoids on expression of cutaneous antimicrobial peptides in northern leopard frogs (Lithobates pipiens)

(2015) Laetitia Tatiersky et al.   BMC Veterinary Research

Development of antimicrobial peptide defenses of southern leopard frogs, Rana sphenocephala, against the pathogenic chytrid fungus, Batrachochytrium dendrobatidis

(2015) Whitney M. Holden et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Immunomodulatory Metabolites Released by the Frog-Killing Fungus Batrachochytrium dendrobatidis

(2015) Louise A. Rollins-Smith et al.   INFECTION AND IMMUNITY

The diversity and evolution of anuran skin peptides

(2015) Enrico König et al.   PEPTIDES

Composition of symbiotic bacteria predicts survival in Panamanian golden frogs infected with a lethal fungus

(2015) M. H. Becker et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation

(2015) A. Bataille et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Microbiota and Mucosal Immunity in Amphibians

(2015) Bruno M. Colombo et al.   Frontiers in Immunology

A de novo Assembly of the Common Frog (Rana temporaria) Transcriptome and Comparison of Transcription Following Exposure to Ranavirus and Batrachochytrium dendrobatidis

(2015) Stephen J. Price et al.   PLoS One

Elevated Corticosterone Levels and Changes in Amphibian Behavior Are Associated with Batrachochytrium dendrobatidis (Bd) Infection and Bd Lineage

(2015) Caitlin R. Gabor et al.   PLoS One

Interventions for Reducing Extinction Risk in Chytridiomycosis-Threatened Amphibians

(2014) BEN C. SCHEELE et al.   CONSERVATION BIOLOGY

Transition of Chytrid Fungus Infection from Mouthparts to Hind Limbs During Amphibian Metamorphosis

(2014) Taegan A. McMahon et al.   EcoHealth

Skin sloughing rate increases with chytrid fungus infection load in a susceptible amphibian

(2014) Michel E.B. Ohmer et al.   FUNCTIONAL ECOLOGY

More than Skin Deep: Functional Genomic Basis for Resistance to Amphibian Chytridiomycosis

(2014) Amy R. Ellison et al.   Genome Biology and Evolution

Unusual evolutionary conservation and further species-specific adaptations of a large family of nonclassical MHC class Ib genes across different degrees of genome ploidy in the amphibian subfamily Xenopodinae

(2014) Eva-Stina Edholm et al.   IMMUNOGENETICS

Inhibition of Local Immune Responses by the Frog-Killing Fungus Batrachochytrium dendrobatidis

(2014) J. Scott Fites et al.   INFECTION AND IMMUNITY

Stress and chytridiomycosis: Exogenous exposure to corticosterone does not alter amphibian susceptibility to a fungal pathogen

(2014) Catherine L. Searle et al.   Journal of Experimental Zoology Part A-Ecological Genetics and Physiology

Amphibians acquire resistance to live and dead fungus overcoming fungal immunosuppression

(2014) Taegan A. McMahon et al.   NATURE

Defects in Host Immune Function in Tree Frogs with Chronic Chytridiomycosis

(2014) Sam Young et al.   PLoS One

Recent introduction of a chytrid fungus endangers Western Palearctic salamanders

(2014) A. Martel et al.   SCIENCE

Intracellular sensing of complement C3 activates cell autonomous immunity

(2014) J. C. H. Tam et al.   SCIENCE

Pattern recognition receptors in antifungal immunity

(2014) Anthony Plato et al.   Seminars in Immunopathology

Fighting a Losing Battle: Vigorous Immune Response Countered by Pathogen Suppression of Host Defenses in the Chytridiomycosis-Susceptible Frog Atelopus zeteki

(2014) Amy R. Ellison et al.   G3-Genes Genomes Genetics

First line of defence: the role of sloughing in the regulation of cutaneous microbes in frogs

(2014) R. L. Cramp et al.   Conservation Physiology

Chytridiomycosis and Seasonal Mortality of Tropical Stream-Associated Frogs 15 Years after Introduction ofBatrachochytrium dendrobatidis

(2013) ANDREA D. PHILLOTT et al.   CONSERVATION BIOLOGY

Natural Stressors and Ranavirus Susceptibility in Larval Wood Frogs (Rana sylvatica)

(2013) Brooke C. Reeve et al.   EcoHealth

Mitigating amphibian chytridiomycosis with bioaugmentation: characteristics of effective probiotics and strategies for their selection and use

(2013) Molly C. Bletz et al.   ECOLOGY LETTERS

A novel subtilisin-like serine protease of Batrachochytrium dendrobatidis is induced by thyroid hormone and degrades antimicrobial peptides

(2013) Jose C. Thekkiniath et al.   Fungal Biology

Non-invasive monitoring of glucocorticoid physiology within highland and lowland populations of native Australian Great Barred Frog (Mixophyes fasciolatus)

(2013) Clara M Graham et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Pathogenic Fungus Microsporum canis Activates the NLRP3 Inflammasome

(2013) Liming Mao et al.   INFECTION AND IMMUNITY

Skin peptides protect juvenile leopard frogs (Rana pipiens) against chytridiomycosis

(2013) J. D. Pask et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Interspecific and Postmetamorphic Variation in Susceptibility of Three North American Anurans toBatrachochytrium dendrobatidis

(2013) Manuel E. Ortiz-Santaliestra et al.   JOURNAL OF HERPETOLOGY

IMMUNIZATION IS INEFFECTIVE AT PREVENTING INFECTION AND MORTALITY DUE TO THE AMPHIBIAN CHYTRID FUNGUS BATRACHOCHYTRIUM DENDROBATIDIS

(2013) Mary J. Stice et al.   JOURNAL OF WILDLIFE DISEASES

Prior Infection Does Not Improve Survival against the Amphibian Disease Chytridiomycosis

(2013) Scott D. Cashins et al.   PLoS One

A Non-Invasive Stress Assay Shows That Tadpole Populations Infected with Batrachochytrium dendrobatidis Have Elevated Corticosterone Levels

(2013) Caitlin R. Gabor et al.   PLoS One

Population Recovery following Decline in an Endangered Stream-Breeding Frog (Mixophyes fleayi) from Subtropical Australia

(2013) David Alan Newell et al.   PLoS One

Host Stress Response Is Important for the Pathogenesis of the Deadly Amphibian Disease, Chytridiomycosis, in Litoria caerulea

(2013) John D. Peterson et al.   PLoS One

Batrachochytrium salamandrivorans sp. nov. causes lethal chytridiomycosis in amphibians

(2013) A. Martel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Behavioural fever is a synergic signal amplifying the innate immune response

(2013) S. Boltana et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Invasive Chytrid Fungus of Amphibians Paralyzes Lymphocyte Responses

(2013) J. S. Fites et al.   SCIENCE

Fundamental roles of the innate-like repertoire of natural antibodies in immune homeostasis

(2013) Jaya Vas et al.   Frontiers in Immunology

Soil bioaugmentation with amphibian cutaneous bacteria protects amphibian hosts from infection by Batrachochytrium dendrobatidis

(2012) Carly R. Muletz et al.   BIOLOGICAL CONSERVATION

Tolerance of fungal infection in European water frogs exposed to Batrachochytrium dendrobatidis after experimental reduction of innate immune defenses

(2012) Douglas C Woodhams et al.   BMC Veterinary Research

Urinary corticosterone metabolites and chytridiomycosis disease prevalence in a free-living population of male Stony Creek frogs (Litoria wilcoxii)

(2012) Christina Kindermann et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Selecting for Tolerance against Pathogens and Herbivores to Enhance Success of Reintroduction and Translocation

(2012) MATTHEW D. VENESKY et al.   CONSERVATION BIOLOGY

Host invasion by Batrachochytrium dendrobatidis: fungal and epidermal ultrastructure in model anurans

(2012) SE Greenspan et al.   DISEASES OF AQUATIC ORGANISMS

Changes in cutaneous microbial abundance with sloughing: possible implications for infection and disease in amphibians

(2012) EA Meyer et al.   DISEASES OF AQUATIC ORGANISMS

Screening bacterial metabolites for inhibitory effects against Batrachochytrium dendrobatidis using a spectrophotometric assay

(2012) SC Bell et al.   DISEASES OF AQUATIC ORGANISMS

Towards a Better Understanding of the Use of Probiotics for Preventing Chytridiomycosis in Panamanian Golden Frogs

(2012) Matthew H. Becker et al.   EcoHealth

GENETIC EROSION IN WILD POPULATIONS MAKES RESISTANCE TO A PATHOGEN MORE COSTLY

(2012) Emilien Luquet et al.   EVOLUTION

Immune evasion or avoidance: Fungal skin infection linked to reduced defence peptides in Australian green-eyed treefrogs, Litoria serrata

(2012) Douglas C. Woodhams et al.   Fungal Biology

Hybrid advantage in skin peptide immune defenses of water frogs (Pelophylax esculentus) at risk from emerging pathogens

(2012) Janine M. Daum et al.   INFECTION GENETICS AND EVOLUTION

Synergistic Inhibition of the Lethal Fungal Pathogen Batrachochytrium dendrobatidis: The Combined Effect of Symbiotic Bacterial Metabolites and Antimicrobial Peptides of the Frog Rana muscosa

(2012) Jillian M. Myers et al.   JOURNAL OF CHEMICAL ECOLOGY

Only skin deep: shared genetic response to the deadly chytrid fungus in susceptible frog species

(2012) ERICA BREE ROSENBLUM et al.   MOLECULAR ECOLOGY

Waterfowl: Potential Environmental Reservoirs of the Chytrid Fungus Batrachochytrium dendrobatidis

(2012) An Garmyn et al.   PLoS One

Germ Tube Mediated Invasion of Batrachochytrium dendrobatidis in Amphibian Skin Is Host Dependent

(2012) Pascale Van Rooij et al.   PLoS One

Surviving Chytridiomycosis: Differential Anti-Batrachochytrium dendrobatidis Activity in Bacterial Isolates from Three Lowland Species of Atelopus

(2012) Sandra V. Flechas et al.   PLoS One

Temperature alters reproductive life history patterns in Batrachochytrium dendrobatidis, a lethal pathogen associated with the global loss of amphibians

(2012) Jamie Voyles et al.   Ecology and Evolution

DAMP signaling in fungal infections and diseases

(2012) Cristina Cunha et al.   Frontiers in Immunology

Human Lysozyme has Fungicidal Activity against Nasal Fungi

(2011) Charmaine M. Woods et al.   American Journal of Rhinology & Allergy

Temperature, hydric environment, and prior pathogen exposure alter the experimental severity of chytridiomycosis in boreal toads

(2011) PJ Murphy et al.   DISEASES OF AQUATIC ORGANISMS

Motile Zoospores of Batrachochytrium dendrobatidis Move Away from Antifungal Metabolites Produced by Amphibian Skin Bacteria

(2011) Brianna A. Lam et al.   EcoHealth

The ebb and flow of antimicrobial skin peptides defends northern leopard frogs (Rana pipiens) against chytridiomycosis

(2011) James D. Pask et al.   GLOBAL CHANGE BIOLOGY

Amphibian Immune Defenses against Chytridiomycosis: Impacts of Changing Environments

(2011) L. A. Rollins-Smith et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Dietary protein restriction impairs growth, immunity, and disease resistance in southern leopard frog tadpoles

(2011) Matthew D. Venesky et al.   OECOLOGIA

MHC genotypes associate with resistance to a frog-killing fungus

(2011) A. E. Savage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The contribution of skin antimicrobial peptides to the system of innate immunity in anurans

(2010) J. Michael Conlon   CELL AND TISSUE RESEARCH

Immune Defenses against Batrachochytrium dendrobatidis, a Fungus Linked to Global Amphibian Declines, in the South African Clawed Frog, Xenopus laevis

(2010) J. P. Ramsey et al.   INFECTION AND IMMUNITY

Remarkable Conservation of Distinct Nonclassical MHC Class I Lineages in Divergent Amphibian Species

(2010) A. Goyos et al.   JOURNAL OF IMMUNOLOGY

Global Emergence ofBatrachochytrium dendrobatidisand Amphibian Chytridiomycosis in Space, Time, and Host

(2009) Matthew C. Fisher et al.   Annual Review of Microbiology

The role of amphibian antimicrobial peptides in protection of amphibians from pathogens linked to global amphibian declines

(2009) Louise A. Rollins-Smith   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Proportion of individuals with anti- Batrachochytrium dendrobatidis skin bacteria is associated with population persistence in the frog Rana muscosa

(2009) Brianna A. Lam et al.   BIOLOGICAL CONSERVATION

Comparative and developmental study of the immune system inXenopus

(2009) Jacques Robert et al.   DEVELOPMENTAL DYNAMICS

Skin microbes on frogs prevent morbidity and mortality caused by a lethal skin fungus

(2009) Reid N Harris et al.   ISME Journal

Evidence for Directional Selection at a Novel Major Histocompatibility Class I Marker in Wild Common Frogs (Rana temporaria) Exposed to a Viral Pathogen (Ranavirus)

(2009) Amber G. F. Teacher et al.   PLoS One

Genome-Wide Transcriptional Response of Silurana (Xenopus) tropicalis to Infection with the Deadly Chytrid Fungus

(2009) Erica Bree Rosenblum et al.   PLoS One

Expression Profiling the Temperature-Dependent Amphibian Response to Infection by Batrachochytrium dendrobatidis

(2009) Laia Ribas et al.   PLoS One

Thermoregulatory behaviour affects prevalence of chytrid fungal infection in a wild population of Panamanian golden frogs

(2009) C. L. Richards-Zawacki   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Pathogenesis of Chytridiomycosis, a Cause of Catastrophic Amphibian Declines

(2009) J. Voyles et al.   SCIENCE

Chytridiomycosis and Amphibian Population Declines Continue to Spread Eastward in Panama

(2008) Douglas C. Woodhams et al.   EcoHealth

LIFE-HISTORY TRADE-OFFS INFLUENCE DISEASE IN CHANGING CLIMATES: STRATEGIES OF AN AMPHIBIAN PATHOGEN

(2008) Douglas C. Woodhams et al.   ECOLOGY

Fungal strategies for overcoming host innate immune response

(2008) Louis Y. A. Chai et al.   MEDICAL MYCOLOGY

Complement and fungal pathogens: an update

(2008) Cornelia Speth et al.   MYCOSES