Metabolite-Sensing G Protein Coupled Receptor TGR5 Protects Host From Viral Infection Through Amplifying Type I Interferon Responses

Inhibition of Rspo-Lgr4 facilitates checkpoint blockade therapy by switching macrophage polarization

(2018) Binghe Tan et al.   CANCER RESEARCH

Kisspeptin/GPR54 signaling restricts antiviral innate immune response through regulating calcineurin phosphatase activity

(2018) Hongjun Huang et al.   Science Advances

Elimination of GPR146-mediated antiviral function through IRF3/HES1-signalling pathway

(2017) Hongjun Huang et al.   IMMUNOLOGY

Leucine-rich repeat-containing G protein–coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein

(2017) Na Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydroquinone suppresses IFN-β expression by targeting AKT/IRF3 pathway

(2017) Yong Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

The microbial metabolite desaminotyrosine protects from influenza through type I interferon

(2017) Ashley L. Steed et al.   SCIENCE

Metabolism meets immunity: The role of free fatty acid receptors in the immune system

(2016) Elisa Alvarez-Curto et al.   BIOCHEMICAL PHARMACOLOGY

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection

(2016) Gahl Levy et al.   Nature Chemical Biology

The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens

(2016) Jinxia Sun et al.   Cell Reports

TGR5, Not Only a Metabolic Regulator

(2016) Cong Guo et al.   Frontiers in Physiology

A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

(2016) Akio Ohta   Frontiers in Immunology

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism

(2014) Nicola Oehler et al.   HEPATOLOGY

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

(2014) Alessia Perino et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular UDP and P2Y6Function as a Danger Signal To Protect Mice from Vesicular Stomatitis Virus Infection through an Increase in IFN-β Production

(2014) Ruimei Li et al.   JOURNAL OF IMMUNOLOGY

Bile Acid Receptor TGR5 Agonism Induces NO Production and Reduces Monocyte Adhesion in Vascular Endothelial Cells

(2013) Taiki Kida et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabolomic Analysis of Key Regulatory Metabolites in Hepatitis C Virus–infected Tree Shrews

(2012) Hui Sun et al.   MOLECULAR & CELLULAR PROTEOMICS

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

P2Y6 Agonist Uridine 5'-Diphosphate Promotes Host Defense against Bacterial Infection via Monocyte Chemoattractant Protein-1-Mediated Monocytes/Macrophages Recruitment

(2011) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Systems Biology of Interferon Responses

(2011) Paul Hertzog et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Inhibitory Effects of Bile Acids and Synthetic Farnesoid X Receptor Agonists on Rotavirus Replication

(2011) Y. Kim et al.   JOURNAL OF VIROLOGY

Limited Effects of Bile Acids and Small Heterodimer Partner on Hepatitis B Virus Biosynthesis In Vivo

(2011) V. C. Reese et al.   JOURNAL OF VIROLOGY

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

(2010) Thijs W.H. Pols et al.   JOURNAL OF HEPATOLOGY

Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1

(2010) S. M. Joung et al.   JOURNAL OF IMMUNOLOGY

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

(2009) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆

(2008) M MATSUMOTO et al.   ADVANCED DRUG DELIVERY REVIEWS