Kisspeptin/GPR54 signaling restricts antiviral innate immune response through regulating calcineurin phosphatase activity

Metabolism meets immunity: The role of free fatty acid receptors in the immune system

(2016) Elisa Alvarez-Curto et al.   BIOCHEMICAL PHARMACOLOGY

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1

(2016) Guanhua Song et al.   NATURE IMMUNOLOGY

The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens

(2016) Jinxia Sun et al.   Cell Reports

A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

(2016) Akio Ohta   Frontiers in Immunology

PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1

(2016) W. Xiang et al.   Science Advances

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Phosphatase PP4 Negatively Regulates Type I IFN Production and Antiviral Innate Immunity by Dephosphorylating and Deactivating TBK1

(2015) Zhenzhen Zhan et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation

(2015) Zexing Li et al.   PLoS Pathogens

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage

(2014) Meidi Gu et al.   CELLULAR SIGNALLING

Hypothalamic Kiss1 and RFRP gene expressions are changed by a high dose of lipopolysaccharide in female rats

(2014) Takeshi Iwasa et al.   HORMONES AND BEHAVIOR

Recruitment of Phosphatase PP2A by RACK1 Adaptor Protein Deactivates Transcription Factor IRF3 and Limits Type I Interferon Signaling

(2014) Lingyun Long et al.   IMMUNITY

Ubiquitin-Specific Protease 2b Negatively Regulates IFN-β Production and Antiviral Activity by Targeting TANK-Binding Kinase 1

(2014) Lei Zhang et al.   JOURNAL OF IMMUNOLOGY

PRR Repeats in the Intracellular Domain of KISS1R Are Important for Its Export to Cell Membrane

(2013) Lucie Chevrier et al.   MOLECULAR ENDOCRINOLOGY

Cyclosporin A Inhibits Rotavirus Replication and Restores Interferon-Beta Signaling Pathway In Vitro and In Vivo

(2013) Zigang Shen et al.   PLoS One

Dependence of fertility on kisspeptin–Gpr54 signaling at the GnRH neuron

(2013) Milen Kirilov et al.   Nature Communications

KiSS1 and its G-protein-coupled receptor GPR54 in cancer development and metastasis

(2012) Sung-Gook Cho et al.   CANCER AND METASTASIS REVIEWS

PPM1B negatively regulates antiviral response via dephosphorylating TBK1

(2012) Yanling Zhao et al.   CELLULAR SIGNALLING

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

(2011) Shitao Li et al.   IMMUNITY

P2Y6 Agonist Uridine 5'-Diphosphate Promotes Host Defense against Bacterial Infection via Monocyte Chemoattractant Protein-1-Mediated Monocytes/Macrophages Recruitment

(2011) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Glycogen Synthase Kinase 3β Regulates IRF3 Transcription Factor-Mediated Antiviral Response via Activation of the Kinase TBK1

(2010) Cao-Qi Lei et al.   IMMUNITY

A Novel Loss-of-Function Mutation inGPR54/KISS1RLeads to Hypogonadotropic Hypogonadism in a Highly Consanguineous Family

(2010) Revital Nimri et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Type I interferon: friend or foe?

(2010) Giorgio Trinchieri   JOURNAL OF EXPERIMENTAL MEDICINE

Virus-Induced Ca2+ Influx Extends Survival of West Nile Virus-Infected Cells

(2010) S. V. Scherbik et al.   JOURNAL OF VIROLOGY

Cyclosporin A inhibits hepatitis C virus replication and restores interferon-alpha expression in hepatocytes

(2010) J.-P. Liu et al.   Transplant Infectious Disease

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

A Conserved Docking Surface on Calcineurin Mediates Interaction with Substrates and Immunosuppressants

(2009) Antonio Rodríguez et al.   MOLECULAR CELL

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

(2009) Chen Wang et al.   NATURE IMMUNOLOGY

Physical association of GPR54 C-terminal with protein phosphatase 2A

(2008) Barry J. Evans et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages

(2008) X. Liu et al.   BLOOD

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

(2008) Constantin S Friedman et al.   EMBO REPORTS

AGPR54-Activating Mutation in a Patient with Central Precocious Puberty

(2008) Milena Gurgel Teles et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intracellular signaling pathways activated by kisspeptins through GPR54: Do multiple signals underlie function diversity?

(2008) Justo P. Castaño et al.   PEPTIDES

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA