Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes

CRISPR-Cas9–Mediated Modification of the NOD Mouse Genome With Ptpn22 R619W Mutation Increases Autoimmune Diabetes

(2016) Xiaotian Lin et al.   DIABETES

Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1

(2016) Chaitali Dutta et al.   MOLECULAR THERAPY

Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)

(2015) Kostas Kakleas et al.   AUTOIMMUNITY REVIEWS

Immunoregulatory Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles on T Lymphocytes

(2015) Andrea Del Fattore et al.   CELL TRANSPLANTATION

Nanoparticle-based autoimmune disease therapy

(2015) Pau Serra et al.   CLINICAL IMMUNOLOGY

A brief glimpse over the horizon for type 1 diabetes nanotherapeutics

(2015) Yesica Garciafigueroa et al.   CLINICAL IMMUNOLOGY

Nucleic Acids Delivery Systems: A Challenge for Pharmaceutical Technologists

(2015) Ana Silva et al.   CURRENT DRUG METABOLISM

Impact of disease heterogeneity on treatment efficacy of immunotherapy in Type 1 diabetes: different shades of gray

(2015) Nicky JC Woittiez et al.   Immunotherapy

The rise, fall, and resurgence of immunotherapy in type 1 diabetes

(2015) Moufida Ben Nasr et al.   PHARMACOLOGICAL RESEARCH

Use of Autoantigen-Loaded Phosphatidylserine-Liposomes to Arrest Autoimmunity in Type 1 Diabetes

(2015) Irma Pujol-Autonell et al.   PLoS One

Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment

(2015) Xiaoqi Liu   Translational Oncology

Insulin administration: present strategies and future directions for a noninvasive (possibly more physiological) delivery

(2015) Elena Matteucci et al.   Drug Design Development and Therapy

Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease

(2015) Robert C. Sharp et al.   Frontiers in Cellular and Infection Microbiology

Breaking Tolerance to Thyroid Antigens: Changing Concepts in Thyroid Autoimmunity

(2014) Sandra M. McLachlan et al.   ENDOCRINE REVIEWS

MECHANISMS IN ENDOCRINOLOGY: Autoimmune thyroid disease: old and new players

(2014) Grigoris Effraimidis et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Nanomedicine in autoimmunity

(2014) Xavier Clemente-Casares et al.   IMMUNOLOGY LETTERS

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Autoimmunity-Associated LYP-W620 Does Not Impair Thymic Negative Selection of Autoreactive T Cells

(2014) Dennis J. Wu et al.   PLoS One

Altered B Cell Homeostasis and Toll-Like Receptor 9-Driven Response in Type 1 Diabetes Carriers of the C1858T PTPN22 Allelic Variant: Implications in the Disease Pathogenesis

(2014) Elena Gianchecchi et al.   PLoS One

Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity

(2013) Elena Gianchecchi et al.   AUTOIMMUNITY REVIEWS

Anti-CD3 clinical trials in type 1 diabetes mellitus

(2013) Anastasia G. Daifotis et al.   CLINICAL IMMUNOLOGY

The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity

(2013) Yaya Wang et al.   IMMUNITY

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

(2013) Xuezhi Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Improving diabetes care in resource-poor countries: challenges and opportunities

(2013) Mark A Atkinson et al.   Lancet Diabetes & Endocrinology

The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity

(2012) Elena Gianchecchi et al.   AUTOIMMUNITY REVIEWS

PTPN22 Silencing in the NOD Model Indicates the Type 1 Diabetes-Associated Allele Is Not a Loss-of-Function Variant

(2012) P. Zheng et al.   DIABETES

Through the Fog: Recent Clinical Trials to Preserve  -Cell Function in Type 1 Diabetes

(2012) C. J. Greenbaum et al.   DIABETES

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

PTPN22 Alters the Development of Regulatory T Cells in the Thymus

(2012) C. J. Maine et al.   JOURNAL OF IMMUNOLOGY

LYP inhibits T-cell activation when dissociated from CSK

(2012) Torkel Vang et al.   Nature Chemical Biology

Pancreatic islet autoimmunity

(2012) Christian Boitard   PRESSE MEDICALE

Inorganic nanovectors for nucleic acid delivery

(2012) Sandhya Pranatharthiharan et al.   Drug Delivery and Translational Research

Designing micro- and nano-particles for treating rheumatoid arthritis

(2011) Samir Mitragotri et al.   ARCHIVES OF PHARMACAL RESEARCH

Successful treatment of rhino-orbital mucormycosis by a new combination therapy with liposomal amphotericin B and micafungin

(2011) Takao Ogawa et al.   AURIS NASUS LARYNX

Editorial [Hot Topic: New Prospects for Treatment of Autoimmune Diseases (Executive Guest Editor: Alessandra Fierabracci)]

(2011) Alessandra Fierabracci   CURRENT PHARMACEUTICAL DESIGN

Decreased hypersensitivity reactions with carboplatin-pegylated liposomal doxorubicin compared to carboplatin-paclitaxel combination: Analysis from the GCIG CALYPSO relapsing ovarian cancer trial

(2011) Florence Joly et al.   GYNECOLOGIC ONCOLOGY

Effects of bevacizumab and pegylated liposomal doxorubicin for the patients with recurrent or refractory ovarian cancers

(2011) Kazuya Kudoh et al.   GYNECOLOGIC ONCOLOGY

Type and composition of surfactants mediating gene transfection of polyethylenimine-coated liposomes

(2011) Praneet Opanasopt et al.   International Journal of Nanomedicine

Silencing disease genes in the laboratory and the clinic

(2011) Jonathan K Watts et al.   JOURNAL OF PATHOLOGY

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

Endocrine autoimmune disease: genetics become complex

(2010) Janneke Wiebolt et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Genetics of the Autoimmune Polyglandular Syndrome Type 3 Variant

(2010) Manuela Dittmar et al.   THYROID

Amphoteric liposomes enable systemic antigen-presenting cell-directed delivery of CD40 antisense and are therapeutically effective in experimental arthritis

(2009) Evangelos Andreakos et al.   ARTHRITIS AND RHEUMATISM

Conjugation of Antisense Oligonucleotides to PEGylated Carbon Nanotubes Enables Efficient Knockdown of PTPN22 in T Lymphocytes

(2009) Lucia G. Delogu et al.   BIOCONJUGATE CHEMISTRY

Efficiency of Liposomes in the Delivery of a Photosensitizer Controlled by the Stereochemistry of a Gemini Surfactant Component

(2009) Cecilia Bombelli et al.   MOLECULAR PHARMACEUTICS

Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs

(2009) Jiaxin Hu et al.   NATURE BIOTECHNOLOGY

Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice

(2009) L. A. Mitchell et al.   Nature Nanotechnology

Cell-Type Specific and Cytoplasmic Targeting of PEGylated Carbon Nanotube-Based Nanoassemblies

(2008) Matthew H. Cato et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice

(2008) Meike L. Schipper et al.   Nature Nanotechnology