Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8+ T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease

CXCL17 Chemokine–Dependent Mobilization of CXCR8+CD8+Effector Memory and Tissue-Resident Memory T Cells in the Vaginal Mucosa Is Associated with Protection against Genital Herpes

(2018) Ruchi Srivastava et al.   JOURNAL OF IMMUNOLOGY

The NKG2D/NKG2DL Axis in the Crosstalk Between Lymphoid and Myeloid Cells in Health and Disease

(2018) Ana Stojanovic et al.   Frontiers in Immunology

Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells

(2018) Felix S. Lichtenegger et al.   Frontiers in Immunology

Induction and transcriptional regulation of the co-inhibitory gene module in T cells

(2018) Norio Chihara et al.   NATURE

Not All Immune Checkpoints Are Created Equal

(2018) Annika De Sousa Linhares et al.   Frontiers in Immunology

Targeting Checkpoint Receptors and Molecules for Therapeutic Modulation of Natural Killer Cells

(2018) Nayoung Kim et al.   Frontiers in Immunology

Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection

(2017) Jeffrey E. Teigler et al.   JOURNAL OF VIROLOGY

CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8 + T EM and CD8 + T RM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease

(2017) Ruchi Srivastava et al.   JOURNAL OF VIROLOGY

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

(2016) Ana C. Anderson et al.   IMMUNITY

Combinatorial approach to cancer immunotherapy: strength in numbers

(2016) Anna E. Vilgelm et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits

(2016) Ruchi Srivastava et al.   JOURNAL OF VIROLOGY

Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44 high CD62L low CD8 + T EM Cells and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpesvirus Infection

(2016) Ruchi Srivastava et al.   JOURNAL OF VIROLOGY

Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice

(2016) Susan P. Foy et al.   PLoS One

Prior Corneal Scarification and Injection of Immune Serum are Not Required Before Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal Disease in Latently Infected Mice

(2015) Lbachir BenMohamed et al.   CURRENT EYE RESEARCH

Cell entry mechanisms of HSV: what we have learned in recent years

(2015) Alex M Agelidis et al.   Future Virology

HLA-A02:01–Restricted Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP11/12 Preferentially Recall Polyfunctional Effector Memory CD8+T Cells from Seropositive Asymptomatic Individuals and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpes

(2015) Ruchi Srivastava et al.   JOURNAL OF IMMUNOLOGY

Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation

(2015) Lbachir BenMohamed et al.   JOURNAL OF NEUROVIROLOGY

Therapeutic Immunization with a Mixture of Herpes Simplex Virus 1 Glycoprotein D-Derived “Asymptomatic” Human CD8+T-Cell Epitopes Decreases Spontaneous Ocular Shedding in Latently Infected HLA Transgenic Rabbits: Association with Low Frequency of Local PD-1+TIM-3+CD8+Exhausted T Cells

(2015) Arif A. Khan et al.   JOURNAL OF VIROLOGY

Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: Implication for the development of an universal CD8+ T-cell epitope-based vaccine

(2014) Sarah Samandary et al.   HUMAN IMMUNOLOGY

Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo

(2014) Nicholas M. Durham et al.   PLoS One

Identification of novel virus-specific antigens by CD4 + and CD8 + T cells from asymptomatic HSV-2 seropositive and seronegative donors

(2014) Deborah Long et al.   VIROLOGY

PD-L1/B7-H1 Regulates the Survival but Not the Function of CD8+ T Cells in Herpes Simplex Virus Type 1 Latently Infected Trigeminal Ganglia

(2013) S. Jeon et al.   JOURNAL OF IMMUNOLOGY

Broadening the Repertoire of Functional Herpes Simplex Virus Type 1-Specific CD8+ T Cells Reduces Viral Reactivation from Latency in Sensory Ganglia

(2013) A. J. St. Leger et al.   JOURNAL OF IMMUNOLOGY

Asymptomatic HLA-A*02:01-Restricted Epitopes from Herpes Simplex Virus Glycoprotein B Preferentially Recall Polyfunctional CD8+ T Cells from Seropositive Asymptomatic Individuals and Protect HLA Transgenic Mice against Ocular Herpes

(2013) X. Dervillez et al.   JOURNAL OF IMMUNOLOGY

Future of an ‘asymptomatic’ T-cell epitope-based therapeutic herpes simplex vaccine

(2012) Xavier Dervillez et al.   Future Virology

Immunodominant “Asymptomatic” Herpes Simplex Virus 1 and 2 Protein Antigens Identified by Probing Whole-ORFome Microarrays with Serum Antibodies from Seropositive Asymptomatic versus Symptomatic Individuals

(2012) Gargi Dasgupta et al.   JOURNAL OF VIROLOGY

Discovery of Potential Diagnostic and Vaccine Antigens in Herpes Simplex Virus 1 and 2 by Proteome-Wide Antibody Profiling

(2012) Mina Kalantari-Dehaghi et al.   JOURNAL OF VIROLOGY

The Herpes Simplex Virus Type 1 Latency-Associated Transcript Inhibits Phenotypic and Functional Maturation of Dendritic Cells

(2012) Aziz Alami Chentoufi et al.   VIRAL IMMUNOLOGY

Control of HSV-1 latency in human trigeminal ganglia—current overview

(2011) Kathrin Held et al.   JOURNAL OF NEUROVIROLOGY

CD8+ T cells patrol HSV-1-infected trigeminal ganglia and prevent viral reactivation

(2011) Anthony J. St. Leger et al.   JOURNAL OF NEUROVIROLOGY

Expression of Herpes Simplex Virus 1-Encoded MicroRNAs in Human Trigeminal Ganglia and Their Relation to Local T-Cell Infiltrates

(2011) K. Held et al.   JOURNAL OF VIROLOGY

The Role of LAT in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1

(2011) S. J. Allen et al.   JOURNAL OF VIROLOGY

The Herpes Simplex Virus 1 Latency-Associated Transcript Promotes Functional Exhaustion of Virus-Specific CD8+ T Cells in Latently Infected Trigeminal Ganglia: a Novel Immune Evasion Mechanism

(2011) A. A. Chentoufi et al.   JOURNAL OF VIROLOGY

CD11c Controls Herpes Simplex Virus 1 Responses To Limit Virus Replication during Primary Infection

(2011) S. J. Allen et al.   JOURNAL OF VIROLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Future viral vectors for the delivery of asymptomatic herpes epitope-based immunotherapeutic vaccines

(2010) Aziz Alami Chentoufi et al.   Future Virology

A Novel HLA (HLA-A*0201) Transgenic Rabbit Model for Preclinical Evaluation of Human CD8 + T Cell Epitope-Based Vaccines against Ocular Herpes

(2010) Aziz A. Chentoufi et al.   JOURNAL OF IMMUNOLOGY

Immunization with Different Viral Antigens Alters the Pattern of T Cell Exhaustion and Latency in Herpes Simplex Virus Type 1-Infected Mice

(2010) S. J. Allen et al.   JOURNAL OF VIROLOGY

Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes

(2010) J. T. Schiffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Presence of Lytic HSV-1 Transcripts and Clonally Expanded T Cells with a Memory Effector Phenotype in Human Sensory Ganglia

(2009) Tobias Derfuss et al.   Annals of the New York Academy of Sciences

New concepts in herpes simplex virus vaccine development: notes from the battlefield

(2009) Gargi Dasgupta et al.   Expert Review of Vaccines

Developing an asymptomatic mucosal herpes vaccine: the present and the future

(2009) Gargi Dasgupta et al.   Future Microbiology

Early CD4 + T Cell Help Prevents Partial CD8 + T Cell Exhaustion and Promotes Maintenance of Herpes Simplex Virus 1 Latency

(2009) Gregory M. Frank et al.   JOURNAL OF IMMUNOLOGY

Neuron-Interacting Satellite Glial Cells in Human Trigeminal Ganglia Have an APC Phenotype

(2009) M. van Velzen et al.   JOURNAL OF IMMUNOLOGY

Mechanisms Employed by Herpes Simplex Virus 1 to Inhibit the Interferon Response

(2009) Patrick Paladino et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

High antigen levels are the cause of T cell exhaustion during chronic viral infection

(2009) S. N. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stern−Gerlach Study of Multidecker Lanthanide−Cyclooctatetraene Sandwich Clusters

(2008) Ken Miyajima et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Level of Herpes Simplex Virus Type 1 Latency Correlates with Severity of Corneal Scarring and Exhaustion of CD8+ T Cells in Trigeminal Ganglia of Latently Infected Mice

(2008) K. R. Mott et al.   JOURNAL OF VIROLOGY

Asymptomatic Human CD4+ Cytotoxic T-Cell Epitopes Identified from Herpes Simplex Virus Glycoprotein B

(2008) A. A. Chentoufi et al.   JOURNAL OF VIROLOGY

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Noncytotoxic Lytic Granule-Mediated CD8+ T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency

(2008) J. E. Knickelbein et al.   SCIENCE