The Role of LAT in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1

Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis

(2014) J. O. Jurado et al.   JOURNAL OF IMMUNOLOGY

siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells

(2010) W. Hobo et al.   BLOOD

HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression

(2010) Bahareh Vali et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B

(2010) Ji Chen et al.   INFLAMMATION RESEARCH

Immune Exhaustion Occurs Concomitantly With Immune Activation and Decrease in Regulatory T Cells in Viremic Chronically HIV-1–Infected Patients

(2010) Meenakshi Sachdeva et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice

(2010) Scott N. Mueller et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-Programmed Cell Death 1 Antibody Reduces CD4 + PD-1 + T Cells and Relieves the Lupus-Like Nephritis of NZB/W F1 Mice

(2010) Shimpei Kasagi et al.   JOURNAL OF IMMUNOLOGY

Immunization with Different Viral Antigens Alters the Pattern of T Cell Exhaustion and Latency in Herpes Simplex Virus Type 1-Infected Mice

(2010) S. J. Allen et al.   JOURNAL OF VIROLOGY

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Presence of Lytic HSV-1 Transcripts and Clonally Expanded T Cells with a Memory Effector Phenotype in Human Sensory Ganglia

(2009) Tobias Derfuss et al.   Annals of the New York Academy of Sciences

The costimulatory role of TIM molecules

(2009) Roselynn Rodriguez-Manzanet et al.   IMMUNOLOGICAL REVIEWS

Chronic Human Infection with Trypanosoma cruzi Drives CD4+ T Cells to Immune Senescence

(2009) M. C. Albareda et al.   JOURNAL OF IMMUNOLOGY

Fewer Latent Herpes Simplex Virus Type 1 and Cytotoxic T Cells Occur in the Ophthalmic Division than in the Maxillary and Mandibular Divisions of the Human Trigeminal Ganglion and Nerve

(2009) K. Hufner et al.   JOURNAL OF VIROLOGY

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

High antigen levels are the cause of T cell exhaustion during chronic viral infection

(2009) S. N. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

(2009) J. S. Yi et al.   SCIENCE

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

(2009) A. Frohlich et al.   SCIENCE

A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages

(2009) Kevin R Mott et al.   Virology Journal

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphoid-Related CD11c+ CD8 + Dendritic Cells Are Involved in Enhancing Herpes Simplex Virus Type 1 Latency

(2008) K. R. Mott et al.   JOURNAL OF VIROLOGY

Level of Herpes Simplex Virus Type 1 Latency Correlates with Severity of Corneal Scarring and Exhaustion of CD8+ T Cells in Trigeminal Ganglia of Latently Infected Mice

(2008) K. R. Mott et al.   JOURNAL OF VIROLOGY