GDNF and the RET Receptor in Cancer: New Insights and Therapeutic Potential
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Title
GDNF and the RET Receptor in Cancer: New Insights and Therapeutic Potential
Authors
Keywords
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Journal
Frontiers in Physiology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-01-07
DOI
10.3389/fphys.2018.01873
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Note: Only part of the references are listed.- RET fusions in a small subset of advanced colorectal cancers at risk of being neglected
- (2018) F Pietrantonio et al. ANNALS OF ONCOLOGY
- Selective RET kinase inhibition for patients with RET-altered cancers
- (2018) V Subbiah et al. ANNALS OF ONCOLOGY
- Drug resistance profiles of mutations in the RET kinase domain
- (2018) Xuan Liu et al. BRITISH JOURNAL OF PHARMACOLOGY
- Clinical significance of RET and RAS mutations in sporadic medullary thyroid carcinoma: a meta-analysis
- (2018) Huy Gia Vuong et al. ENDOCRINE-RELATED CANCER
- Novel targeted therapeutics for MEN2
- (2018) Sara Redaelli et al. ENDOCRINE-RELATED CANCER
- 65 YEARS OF THE DOUBLE HELIX: Exploiting insights on the RET receptor for personalized cancer medicine
- (2018) Lois M Mulligan ENDOCRINE-RELATED CANCER
- Artemin regulates CXCR4 expression to induce migration and invasion in pancreatic cancer cells through activation of NF-κB signaling
- (2018) Juan Wang et al. EXPERIMENTAL CELL RESEARCH
- Molecular Testing Guideline for the Selection of Patients With Lung Cancer for Treatment With Targeted Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Clinical Practice Guideline Update
- (2018) Gregory P. Kalemkerian et al. JOURNAL OF CLINICAL ONCOLOGY
- Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene
- (2018) Duarte Mendes Oliveira et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- GDNF, Neurturin, and Artemin Activate and Sensitize Bone Afferent Neurons and Contribute to Inflammatory Bone Pain
- (2018) Sara Nencini et al. JOURNAL OF NEUROSCIENCE
- Brief Report: Frequency of Brain Metastases and Multikinase Inhibitor Outcomes in Patients with RET -Rearranged Lung Cancers
- (2018) Alexander Drilon et al. Journal of Thoracic Oncology
- Clinical and Translational Implications of RET Rearrangements in Non–Small Cell Lung Cancer
- (2018) Roberto Ferrara et al. Journal of Thoracic Oncology
- RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia
- (2018) S. Rudat et al. LEUKEMIA
- Chronic expression of wild-type Ret receptor in the mammary gland induces luminal tumors that are sensitive to Ret inhibition
- (2018) Albana Gattelli et al. ONCOGENE
- Role of RET protein-tyrosine kinase inhibitors in the treatment RET-driven thyroid and lung cancers
- (2018) Robert Roskoski et al. PHARMACOLOGICAL RESEARCH
- ER-positive breast cancer cells are poised for RET-mediated endocrine resistance
- (2018) Sachi Horibata et al. PLoS One
- Precision Targeted Therapy with BLU-667 for RET -Driven Cancers
- (2018) Vivek Subbiah et al. Cancer Discovery
- Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer
- (2018) Emily E. Bosco et al. Oncotarget
- RET fusions observed in lung and colorectal cancers are sensitive to ponatinib
- (2018) Joseph M. Gozgit et al. Oncotarget
- Expression and copy number gains of the RET gene in 631 early and mid stage non-small cell lung cancer cases
- (2018) Ling Tan et al. Thoracic Cancer
- The GDNF Family: A Role in Cancer?
- (2018) Graeme C. Fielder et al. NEOPLASIA
- Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations
- (2018) Jun Gong et al. Journal for ImmunoTherapy of Cancer
- Molecular Profiling of Salivary Gland Intraductal Carcinoma Revealed a Subset of Tumors Harboring NCOA4-RET and Novel TRIM27-RET Fusions
- (2018) Alena Skálová et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Simultaneous detection of lung fusions using a multiplex RT-PCR next generation sequencing-based approach: a multi-institutional research study
- (2018) Cecily P. Vaughn et al. BMC CANCER
- Multi-kinase RET inhibitor vandetanib combined with mTOR inhibitor everolimus in patients with RET rearranged non-small cell lung cancer.
- (2018) Vivek Subbiah et al. JOURNAL OF CLINICAL ONCOLOGY
- RET-rearranged lung cancers: Immunophenotype and response to immunotherapy.
- (2018) Joshua K. Sabari et al. JOURNAL OF CLINICAL ONCOLOGY
- A phase 1 study of LOXO-292, a potent and highly selective RET inhibitor, in patients with RET-altered cancers.
- (2018) Alexander E. Drilon et al. JOURNAL OF CLINICAL ONCOLOGY
- RET/PTC Gene Rearrangements in Thyroid Carcinogenesis: Assessment and Clinico-Pathological Correlations
- (2018) Mosin S Khan et al. PATHOLOGY & ONCOLOGY RESEARCH
- RET rearrangements are actionable alterations in breast cancer
- (2018) Bhavna S. Paratala et al. Nature Communications
- Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology
- (2018) David L. Steward et al. JAMA Oncology
- RET-mediated modulation of tumor microenvironment and immune response in multiple endocrine neoplasia type 2 (MEN2)
- (2017) Maria Domenica Castellone et al. ENDOCRINE-RELATED CANCER
- Advances in the management of MEN2: from improved surgical and medical treatment to novel kinase inhibitors
- (2017) Samuel A Wells ENDOCRINE-RELATED CANCER
- Structure and function of RET in multiple endocrine neoplasia type 2
- (2017) Iván Plaza-Menacho ENDOCRINE-RELATED CANCER
- Sorafenib for the treatment of breast cancer
- (2017) Giuseppe Bronte et al. EXPERT OPINION ON PHARMACOTHERAPY
- Medullary Thyroid Carcinoma in MEN2A: ATA Moderate- or High-Risk RET Mutations Do Not Predict Disease Aggressiveness
- (2017) Rachel K Voss et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Targeting RET in Patients With RET-Rearranged Lung Cancers: Results From the Global, Multicenter RET Registry
- (2017) Oliver Gautschi et al. JOURNAL OF CLINICAL ONCOLOGY
- Genetic landscape of papillary thyroid carcinoma in the Chinese population
- (2017) Jialong Liang et al. JOURNAL OF PATHOLOGY
- Treatment for the endocrine resistant breast cancer: Current options and future perspectives
- (2017) Chun-Yu Liu et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody–Drug Conjugate for the Treatment of Hormone Receptor–Positive Breast Cancer
- (2017) Sunil Bhakta et al. MOLECULAR CANCER THERAPEUTICS
- Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
- (2017) Jer-Yuan Hsu et al. NATURE
- GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
- (2017) Linda Yang et al. NATURE MEDICINE
- GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
- (2017) Shannon E Mullican et al. NATURE MEDICINE
- The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
- (2017) Paul J Emmerson et al. NATURE MEDICINE
- Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes
- (2017) Alexander Drilon et al. Nature Reviews Clinical Oncology
- Upregulation of RET induces perineurial invasion of pancreatic adenocarcinoma
- (2017) M Amit et al. ONCOGENE
- Expression of NGF, GDNF and MMP-9 in prostate carcinoma
- (2017) Sirin Baspinar et al. PATHOLOGY RESEARCH AND PRACTICE
- PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome
- (2017) Hashem O. Alsaab et al. Frontiers in Pharmacology
- Vandetanib in patients with previously treated RET-rearranged advanced non-small-cell lung cancer (LURET): an open-label, multicentre phase 2 trial
- (2017) Kiyotaka Yoh et al. Lancet Respiratory Medicine
- GDNF secreted by nerves enhances PD-L1 expression via JAK2-STAT1 signaling activation in HNSCC
- (2017) Chengzhong Lin et al. OncoImmunology
- Elevated RET expression enhances EGFR activation and mediates EGFR inhibitor resistance in head and neck squamous cell carcinoma
- (2016) Chengzhong Lin et al. CANCER LETTERS
- Abstract 2295: GDNF family receptor alpha 4 (GFRa4)-targeted adoptive T-cell immunotherapy for medullary thyroid carcinoma
- (2016) Vijay G. Bhoj et al. CANCER RESEARCH
- RET Aberrations in Diverse Cancers: Next-Generation Sequencing of 4,871 Patients
- (2016) Shumei Kato et al. CLINICAL CANCER RESEARCH
- Differential roles of RET isoforms in medullary and papillary thyroid carcinomas
- (2016) Eric Y Lian et al. ENDOCRINE-RELATED CANCER
- Normalizing GDNF expression in the spinal cord alleviates cutaneous hyperalgesia but not ongoing pain in a rat model of bone cancer pain
- (2016) Zhuofeng Ding et al. INTERNATIONAL JOURNAL OF CANCER
- Vandetanib as a potential new treatment for estrogen receptor-negative breast cancers
- (2016) Rana Hatem et al. INTERNATIONAL JOURNAL OF CANCER
- Cabozantinib in patients with advanced RET -rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial
- (2016) Alexander Drilon et al. LANCET ONCOLOGY
- Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
- (2016) Sales Ibiza et al. NATURE
- Landscape of somatic mutations in 560 breast cancer whole-genome sequences
- (2016) Serena Nik-Zainal et al. NATURE
- A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma
- (2016) Cristina Romei et al. Nature Reviews Endocrinology
- Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model
- (2016) Anja Drinkut et al. Cell Death & Disease
- Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts
- (2016) Elena Andreucci et al. Oncotarget
- Tumor Genotype Determines Phenotype and Disease-related Outcomes in Thyroid Cancer
- (2015) Linwah Yip et al. ANNALS OF SURGERY
- Preclinical Efficacy and Safety Assessment of an Antibody-Drug Conjugate Targeting the c-RET Proto-Oncogene for Breast Carcinoma
- (2015) M. Nguyen et al. CLINICAL CANCER RESEARCH
- Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration
- (2015) Durga Praveen Meka et al. JOURNAL OF CLINICAL INVESTIGATION
- Systemic and CNS activity of the RET inhibitor vandetanib combined with the mTOR inhibitor everolimus in KIF5B-RET re-arranged non-small cell lung cancer with brain metastases
- (2015) Vivek Subbiah et al. LUNG CANCER
- Intestinal smooth muscle phenotype determines enteric neuronal survival via GDNF expression
- (2015) T.Y. Han et al. NEUROSCIENCE
- Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma
- (2015) Samuel A. Wells et al. THYROID
- HO-1, RET and PML as possible markers for risk stratification of acute myelocytic leukemia and prognostic evaluation
- (2015) MEISHENG YU et al. Oncology Letters
- DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance
- (2015) Roland M. Huber et al. Oncotarget
- Identification and characterization of RET fusions in advanced colorectal cancer
- (2015) Anne-France Le Rolle et al. Oncotarget
- The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion
- (2015) Peter Soba et al. eLife
- Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients
- (2015) Lorena Lerner et al. Journal of Cachexia Sarcopenia and Muscle
- RET-rearranged non-small-cell lung carcinoma: a clinicopathological and molecular analysis
- (2014) K Tsuta et al. BRITISH JOURNAL OF CANCER
- Expression Variability and Function of the RET Gene in Adult Peripheral Blood Mononuclear Cells
- (2014) Marta Rusmini et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Promoter CpG island methylation of RET predicts poor prognosis in stage II colorectal cancer patients
- (2014) Muriel X.G. Draht et al. Molecular Oncology
- The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function
- (2014) Diogo Fonseca-Pereira et al. NATURE
- GFR 1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling
- (2014) S. He et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Kinase fusions are frequent in Spitz tumours and spitzoid melanomas
- (2014) Thomas Wiesner et al. Nature Communications
- GDNF-RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors
- (2013) A. Morandi et al. CANCER RESEARCH
- The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer
- (2013) Kun Wang et al. CARCINOGENESIS
- Vandetanib in Children and Adolescents with Multiple Endocrine Neoplasia Type 2B Associated Medullary Thyroid Carcinoma
- (2013) E. Fox et al. CLINICAL CANCER RESEARCH
- Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells
- (2013) Albana Gattelli et al. EMBO Molecular Medicine
- Targeting mTOR in RET mutant medullary and differentiated thyroid cancer cells
- (2013) Matti L Gild et al. ENDOCRINE-RELATED CANCER
- The Relationship between Over-expression of Glial Cell-derived Neurotrophic Factor and Its RET Receptor with Progression and Prognosis of Human Pancreatic Cancer
- (2013) Q Zeng et al. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- ASCL1 and RET expression defines a clinically relevant subgroup of lung adenocarcinoma characterized by neuroendocrine differentiation
- (2013) F Kosari et al. ONCOGENE
- Glial cell line-derived neurotrophic factor induces cell migration in human oral squamous cell carcinoma
- (2013) Jing-Yuan Chuang et al. ORAL ONCOLOGY
- Role of glial cell line-derived neurotrophic factor in perineural invasion of pancreatic cancer
- (2012) Han Liu et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor
- (2012) O. Cavel et al. CANCER RESEARCH
- RETFusions Define a Unique Molecular and Clinicopathologic Subtype of Non–Small-Cell Lung Cancer
- (2012) Rui Wang et al. JOURNAL OF CLINICAL ONCOLOGY
- RET fusion genes are associated with chronic myelomonocytic leukemia and enhance monocytic differentiation
- (2012) P Ballerini et al. LEUKEMIA
- Acute myeloid leukemia with translocation (8;16)(p11;p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene
- (2012) M Díaz-Beyá et al. LEUKEMIA
- RET is a potential tumor suppressor gene in colorectal cancer
- (2012) Y Luo et al. ONCOGENE
- Intracellular Signal Transduction and Modification of the Tumor Microenvironment Induced by RET/PTCs in Papillary Thyroid Carcinoma
- (2012) Elisa Menicali et al. Frontiers in Endocrinology
- The rearranged during transfection/papillary thyroid carcinoma tyrosine kinase is an estrogen-dependent gene required for the growth of estrogen receptor positive breast cancer cells
- (2011) Chunyu Wang et al. BREAST CANCER RESEARCH AND TREATMENT
- Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis
- (2011) S. Qiao et al. CLINICAL NEUROPATHOLOGY
- Steroid hormone modulation of RET through two estrogen responsive enhancers in breast cancer
- (2011) Zachary E. Stine et al. HUMAN MOLECULAR GENETICS
- Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial
- (2011) Samuel A. Wells et al. JOURNAL OF CLINICAL ONCOLOGY
- RET in breast cancer: functional and therapeutic implications
- (2011) Andrea Morandi et al. TRENDS IN MOLECULAR MEDICINE
- RET protein expression in papillary renal cell carcinoma
- (2011) Richard Flavin et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- The expression of CXCR4 and its relationship with matrix metalloproteinase-9/vascular endothelial growth factor in esophageal squamous cell cancer
- (2010) C. L. Lu et al. DISEASES OF THE ESOPHAGUS
- Artemin Stimulates Oncogenicity and Invasiveness of Human Endometrial Carcinoma Cells
- (2010) Vijay Pandey et al. ENDOCRINOLOGY
- RET Signaling Is Required for Survival and Normal Function of Nonpeptidergic Nociceptors
- (2010) J. P. Golden et al. JOURNAL OF NEUROSCIENCE
- International Guidelines for Management of Metastatic Breast Cancer: Can Metastatic Breast Cancer Be Cured?
- (2010) O. Pagani et al. JNCI-Journal of the National Cancer Institute
- Paracrine Regulation of Pancreatic Cancer Cell Invasion by Peripheral Nerves
- (2010) Ziv Gil et al. JNCI-Journal of the National Cancer Institute
- Diverse somatic mutation patterns and pathway alterations in human cancers
- (2010) Zhengyan Kan et al. NATURE
- Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance
- (2010) I Plaza-Menacho et al. ONCOGENE
- Transcript Level Modulates the Inherent Oncogenicity of RET/PTC Oncoproteins
- (2009) D. S. Richardson et al. CANCER RESEARCH
- Global Gene Expression Analysis of Reactive Stroma in Prostate Cancer
- (2009) O. Dakhova et al. CLINICAL CANCER RESEARCH
- Medullary thyroid carcinoma identified within the first year of life in children with hereditary multiple endocrine neoplasia type 2A (codon 634) and 2B
- (2009) D Zenaty et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Functional RET G691S polymorphism in cutaneous malignant melanoma
- (2009) N Narita et al. ONCOGENE
- Artemin is oncogenic for human mammary carcinoma cells
- (2009) J Kang et al. ONCOGENE
- Inflammation and cancer: The oncogene-driven connection
- (2008) Maria Grazia Borrello et al. CANCER LETTERS
- The Ret Receptor Tyrosine Kinase Pathway Functionally Interacts with the ER Pathway in Breast Cancer
- (2008) A. Boulay et al. CANCER RESEARCH
- The Structure of the Glial Cell Line-derived Neurotrophic Factor-Coreceptor Complex
- (2008) Vimal Parkash et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- High frequency of level II–V lymph node involvement in RET/PTC positive papillary thyroid carcinoma
- (2007) Y.L. Wang et al. EJSO
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