A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma

Tumor Genotype Determines Phenotype and Disease-related Outcomes in Thyroid Cancer

(2015) Linwah Yip et al.   ANNALS OF SURGERY

Defining “mutation” and “polymorphism” in the era of personal genomics

(2015) Roshan Karki et al.   BMC Medical Genomics

RASproto-oncogene in medullary thyroid carcinoma

(2015) Margarida M Moura et al.   ENDOCRINE-RELATED CANCER

THERAPY OF ENDOCRINE DISEASE: Response and toxicity of small-molecule tyrosine kinase inhibitors in patients with thyroid carcinoma: a systematic review and meta-analysis

(2015) E. N. Klein Hesselink et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

RET Fusion as a Novel Driver of Medullary Thyroid Carcinoma

(2015) Elizabeth G. Grubbs et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lenvatinib versus Placebo in Radioiodine-Refractory Thyroid Cancer

(2015) Martin Schlumberger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Relevance ofBRAFV600EMutation Testing VersusRASPoint Mutations andRET/PTCRearrangements Evaluation in the Diagnosis of Thyroid Cancer

(2015) Martina Rossi et al.   THYROID

Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma

(2015) Samuel A. Wells et al.   THYROID

Impact of the Multi-Gene ThyroSeq Next-Generation Sequencing Assay on Cancer Diagnosis in Thyroid Nodules with Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Cytology

(2015) Yuri E. Nikiforov et al.   THYROID

Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer

(2015) Jun Ho Ji et al.   PLoS Genetics

Integrated Genomic Characterization of Papillary Thyroid Carcinoma

(2014) Nishant Agrawal et al.   CELL

Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma

(2014) T. Nakaoku et al.   CLINICAL CANCER RESEARCH

Twenty years of lesson learning: how does theRETgenetic screening test impact the clinical management of medullary thyroid cancer?

(2014) Cristina Romei et al.   CLINICAL ENDOCRINOLOGY

Comprehensive assessment of the disputed RET Y791F variant shows no association with medullary thyroid carcinoma susceptibility

(2014) Rodrigo A Toledo et al.   ENDOCRINE-RELATED CANCER

A Single-Tube Multiplexed Assay for Detecting ALK, ROS1, and RET Fusions in Lung Cancer

(2014) Maruja E. Lira et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial

(2014) Marcia S Brose et al.   LANCET

High-throughput mutation profiling improves diagnostic stratification of sporadic medullary thyroid carcinomas

(2014) Michele Simbolo et al.   VIRCHOWS ARCHIV

Is there really an increased incidence of thyroid cancer?

(2014) Juan P. Brito et al.   Current Opinion in Endocrinology Diabetes and Obesity

RET Recognition of GDNF-GFRα1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association

(2014) Kerry M. Goodman et al.   Cell Reports

The clinical spectrum of RET proto-oncogene mutations in codon 790

(2013) Hélène Bihan et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Multiple Endocrine Neoplasia Type 2 and Familial Medullary Thyroid Carcinoma: An Update

(2013) Samuel A. Wells et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers

(2013) Julio C. Ricarte-Filho et al.   JOURNAL OF CLINICAL INVESTIGATION

Cabozantinib in Progressive Medullary Thyroid Cancer

(2013) Rossella Elisei et al.   JOURNAL OF CLINICAL ONCOLOGY

Functional characterization of a novel FGFR1OP-RET rearrangement in hematopoietic malignancies

(2013) Daniela Bossi et al.   Molecular Oncology

Response to Cabozantinib in Patients with RET Fusion-Positive Lung Adenocarcinomas

(2013) Alexander Drilon et al.   Cancer Discovery

Frequency of close positioning of chromosomal loci detected by FRET correlates with their participation in carcinogenic rearrangements in human cells

(2012) Manoj Gandhi et al.   GENES CHROMOSOMES & CANCER

Modifications in the Papillary Thyroid Cancer Gene Profile Over the Last 15 Years

(2012) Cristina Romei et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

RETFusions Define a Unique Molecular and Clinicopathologic Subtype of Non–Small-Cell Lung Cancer

(2012) Rui Wang et al.   JOURNAL OF CLINICAL ONCOLOGY

Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 2 trial

(2012) Sophie Leboulleux et al.   LANCET ONCOLOGY

RET fusion genes are associated with chronic myelomonocytic leukemia and enhance monocytic differentiation

(2012) P Ballerini et al.   LEUKEMIA

Alternative splicing results in RET isoforms with distinct trafficking properties

(2012) Douglas S. Richardson et al.   MOLECULAR BIOLOGY OF THE CELL

KIF5B-RET fusions in lung adenocarcinoma

(2012) Takashi Kohno et al.   NATURE MEDICINE

Advances in the follow-up of differentiated or medullary thyroid cancer

(2012) Rossella Elisei et al.   Nature Reviews Endocrinology

Low Prevalence of the Somatic M918T RET Mutation in Micro-Medullary Thyroid Cancer

(2012) Cristina Romei et al.   THYROID

Evidence of a Low Prevalence of RAS Mutations in a Large Medullary Thyroid Cancer Series

(2012) Raffaele Ciampi et al.   THYROID

Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2

(2012) C. Romei et al.   Journal of Oncology

In vitro transforming potential, intracellular signaling properties, and sensitivity to a kinase inhibitor (sorafenib) of RET proto-oncogene variants Glu511Lys, Ser649Leu, and Arg886Trp

(2011) H. Prazeres et al.   ENDOCRINE-RELATED CANCER

In silico and in vitro analysis of rare germline allelic variants of RET oncogene associated with medullary thyroid cancer

(2011) B Cosci et al.   ENDOCRINE-RELATED CANCER

Combined RET and Ki-67 assessment in sporadic medullary thyroid carcinoma: a useful tool for patient risk stratification

(2011) Caterina Mian et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

ENDOCRINE TUMOURS: Approach to the patient with advanced differentiated thyroid cancer

(2011) M Schlumberger et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

High Prevalence ofRASMutations inRET-Negative Sporadic Medullary Thyroid Carcinomas

(2011) Margarida M. Moura et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Timing of Total Thyroidectomy inRETGene Mutation Carriers Could Be Personalized and Safely Planned on the Basis of Serum Calcitonin: 18 Years Experience at One Single Center

(2011) Rossella Elisei et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial

(2011) Samuel A. Wells et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeted therapies for thyroid tumors

(2011) Steven I Sherman   MODERN PATHOLOGY

Predicting Phenotypic Severity of Uncertain Gene Variants in the RET Proto-Oncogene

(2011) David K. Crockett et al.   PLoS One

Improved detection does not fully explain the rising incidence of well-differentiated thyroid cancer: a population-based analysis

(2010) Luc G.T. Morris et al.   AMERICAN JOURNAL OF SURGERY

Multiple endocrine neoplasia type 2

(2010) Nelson Wohllk et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Role of H2O2 in RET/PTC1 Chromosomal Rearrangement Produced by Ionizing Radiation in Human Thyroid Cells

(2010) R. Ameziane-El-Hassani et al.   CANCER RESEARCH

RET genetic screening of sporadic medullary thyroid cancer (MTC) allows the preclinical diagnosis of unsuspected gene carriers and the identification of a relevant percentage of hidden familial MTC (FMTC)

(2010) C. Romei et al.   CLINICAL ENDOCRINOLOGY

Prevalence of RET/PTC rearrangement in benign and malignant thyroid nodules and its clinical application

(2010) Anna Guerra et al.   ENDOCRINE JOURNAL

Multiple endocrine neoplasia type 2 syndromes (MEN 2): results from the ItaMEN network analysis on the prevalence of different genotypes and phenotypes

(2010) Cristina Romei et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

RET rearrangements and BRAF mutation in undifferentiated thyroid carcinomas having papillary carcinoma components

(2010) Kunio Mochizuki et al.   HISTOPATHOLOGY

Risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germline RET mutations located in exon 10

(2010) Karin Frank-Raue et al.   HUMAN MUTATION

Impact of Proto-Oncogene Mutation Detection in Cytological Specimens from Thyroid Nodules Improves the Diagnostic Accuracy of Cytology

(2010) Silvia Cantara et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells

(2010) M Gandhi et al.   ONCOGENE

Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas

(2009) M M Moura et al.   BRITISH JOURNAL OF CANCER

Rising Thyroid Cancer Incidence in the United States by Demographic and Tumor Characteristics, 1980-2005

(2009) L. Enewold et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA, and AKT1

(2009) J. C. Ricarte-Filho et al.   CANCER RESEARCH

Multiple endocrine neoplasia type 2RETprotooncogene database: Repository of MEN2-associatedRETsequence variation and reference for genotype/phenotype correlations

(2009) Rebecca L. Margraf et al.   HUMAN MUTATION

RET/PTC Rearrangement Occurring in Primary Peritoneal Carcinoma

(2009) Richard Flavin et al.   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Pathogenicity of DNA Variants and Double Mutations in Multiple Endocrine Neoplasia Type 2 and Von Hippel-Lindau Syndrome

(2009) Zoran Erlic et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets

(2009) Aniello Cerrato et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mechanisms of chromosomal rearrangements in solid tumors: The model of papillary thyroid carcinoma

(2009) Manoj Gandhi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Medullary Thyroid Cancer: Management Guidelines of the American Thyroid Association

(2009) Richard T. Kloos (Chair) et al.   THYROID

Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer

(2009) David S. Cooper et al.   THYROID

Fine-needle aspiration of the thyroid: today and tomorrow

(2008) Zubair W. Baloch et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Difference in development of medullary thyroid carcinoma among carriers of RET mutations in codons 790 and 791*

(2008) Karin Frank-Raue et al.   CLINICAL ENDOCRINOLOGY

BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer

(2008) C. Romei et al.   ENDOCRINE-RELATED CANCER

Modification of multiple endocrine neoplasia 2A phenotype by cell membrane proximity of RET mutations in exon 10

(2008) Andreas Machens et al.   ENDOCRINE-RELATED CANCER

RET oncogene in MEN2, MEN2B, MTC and other forms of thyroid cancer

(2008) Maya B Lodish et al.   Expert Review of Anticancer Therapy

Highly Prevalent Genetic Alterations in Receptor Tyrosine Kinases and Phosphatidylinositol 3-Kinase/Akt and Mitogen-Activated Protein Kinase Pathways in Anaplastic and Follicular Thyroid Cancers

(2008) Zhi Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prognostic Significance of SomaticRETOncogene Mutations in Sporadic Medullary Thyroid Cancer: A 10-Year Follow-Up Study

(2007) Rossella Elisei et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM