Cannabinoids and Pain: New Insights From Old Molecules

Do medical marijuana laws reduce addictions and deaths related to pain killers?

(2018) David Powell et al.   JOURNAL OF HEALTH ECONOMICS

Antiepileptic drugs as analgesics/adjuvants in inflammatory pain: current preclinical evidence

(2018) Maja Tomić et al.   PHARMACOLOGY & THERAPEUTICS

Drug-drug interactions as a result of co-administering Δ9-THC and CBD with other psychotropic agents

(2017) Carola Rong et al.   Expert Opinion On Drug Safety

Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y12 and P2Y13 receptors in neuropathic pain rats

(2017) Juan Niu et al.   Journal of Neuroinflammation

Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep

(2017) Brian J Piper et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The cannabinoid system and pain

(2017) Stephen G. Woodhams et al.   NEUROPHARMACOLOGY

Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities

(2017) Leepakshi Khurana et al.   NEUROPHARMACOLOGY

Opioid-Sparing Effect of Cannabinoids: A Systematic Review and Meta-Analysis

(2017) Suzanne Nielsen et al.   NEUROPSYCHOPHARMACOLOGY

US Epidemiology of Cannabis Use and Associated Problems

(2017) Deborah S Hasin   NEUROPSYCHOPHARMACOLOGY

The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABA A receptors

(2017) T. Bakas et al.   PHARMACOLOGICAL RESEARCH

Cannabis and Cannabinoids for Chronic Pain

(2017) E. Alfonso Romero-Sandoval et al.   Current Rheumatology Reports

Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

(2017) Richard A. Slivicki et al.   BIOLOGICAL PSYCHIATRY

Arylboronic acids as dual-action FAAH and TRPV1 ligands

(2016) Enrico Morera et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An update on PPAR activation by cannabinoids

(2016) Saoirse Elizabeth O'Sullivan   BRITISH JOURNAL OF PHARMACOLOGY

The CB2 receptor and its role as a regulator of inflammation

(2016) Caroline Turcotte et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TRPV1-FAAH-COX: TheCouples Gamein Pain Treatment

(2016) Francesca Aiello et al.   ChemMedChem

Prevention of Renal Complications Induced by Non- Steroidal Anti-Inflammatory Drugs

(2016) Sonja Vu|kovi| et al.   CURRENT MEDICINAL CHEMISTRY

Rescue of Impaired mGluR5-Driven Endocannabinoid Signaling Restores Prefrontal Cortical Output to Inhibit Pain in Arthritic Rats

(2016) T. Kiritoshi et al.   JOURNAL OF NEUROSCIENCE

Medical Cannabis Use Is Associated With Decreased Opiate Medication Use in a Retrospective Cross-Sectional Survey of Patients With Chronic Pain

(2016) Kevin F. Boehnke et al.   JOURNAL OF PAIN

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase

(2016) Lawrence M Carey et al.   Molecular Pain

Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases (fibromyalgia syndrome, back pain, osteoarthritis, rheumatoid arthritis)

(2016) M.-A. Fitzcharles et al.   SCHMERZ

Safety, Tolerability and Pharmacokinetics of FAAH Inhibitor V158866: A Double-Blind, Randomised, Placebo-Controlled Phase I Study in Healthy Volunteers

(2016) Stephen Pawsey et al.   Drugs in research & development

Lessons from the fatal French study BIA-10-2474

(2016) Nicholas Moore   BMJ-British Medical Journal

Lessons from the fatal French study BIA-10-2474

(2016) Nicholas Moore   BMJ-British Medical Journal

Cannabis sativa: The Plant of the Thousand and One Molecules

(2016) Christelle M. Andre et al.   Frontiers in Plant Science

Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems—A Novel Treatment Option for Chronic Pain Management

(2016) Natalia Malek et al.   Frontiers in Pharmacology

A preliminary evaluation of the relationship of cannabinoid blood concentrations with the analgesic response to vaporized cannabis

(2016) Barth Wilsey et al.   Journal of Pain Research

Medical cannabis ‒ the Canadian perspective 

(2016) Sabrina Ramkellawan et al.   Journal of Pain Research

Pharmacological Management of Chronic Neuropathic Pain: Revised Consensus Statement from the Canadian Pain Society

(2016) DE Moulin et al.   Pain Research & Management

Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1–Dependent Withdrawal

(2015) Liting Deng et al.   BIOLOGICAL PSYCHIATRY

Cannabidiol (CBD) and its analogs: a review of their effects on inflammation

(2015) Sumner Burstein   BIOORGANIC & MEDICINAL CHEMISTRY

Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model

(2015) Nicholas S. Adamson Barnes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor

(2015) R B Laprairie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabis in cancer care

(2015) DI Abrams et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage

(2015) Oscar Sasso et al.   FASEB JOURNAL

Cannabinoid receptor-specific mechanisms to alleviate pain in sickle cell anemia via inhibition of mast cell activation and neurogenic inflammation

(2015) L. Vincent et al.   HAEMATOLOGICA

Activation of cannabinoid receptor 2 attenuates synovitis and joint distruction in collagen-induced arthritis

(2015) Huan Gui et al.   IMMUNOBIOLOGY

Cannabinoids for Medical Use

(2015) Penny F. Whiting et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cannabinoids for the Treatment of Chronic Non-Cancer Pain: An Updated Systematic Review of Randomized Controlled Trials

(2015) M. E. Lynch et al.   Journal of Neuroimmune Pharmacology

Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data

(2015) Michael H. Andreae et al.   JOURNAL OF PAIN

Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy

(2015) Mark S. Wallace et al.   JOURNAL OF PAIN

Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS)

(2015) Mark A. Ware et al.   JOURNAL OF PAIN

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

(2015) Nanna B Finnerup et al.   LANCET NEUROLOGY

Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain

(2015) Carmen La Porta et al.   PAIN

Receptome: Interactions between three pain-related receptors or the “Triumvirate” of cannabinoid, opioid and TRPV1 receptors

(2015) Ferenc Zádor et al.   PHARMACOLOGICAL RESEARCH

A systematic review of the antipsychotic properties of cannabidiol in humans

(2015) Tabitha A. Iseger et al.   SCHIZOPHRENIA RESEARCH

Endocannabinoid signaling at the periphery: 50 years after THC

(2015) Mauro Maccarrone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis

(2015) Torsten Lowin et al.   ARTHRITIS RESEARCH & THERAPY

Cannabinoid receptor-specific mechanisms to alleviate pain in sickle cell anemia via inhibition of mast cell activation and neurogenic inflammation

(2015) L. Vincent et al.   HAEMATOLOGICA

The Effectiveness of Cannabinoids in the Management of Chronic Nonmalignant Neuropathic Pain: A Systematic Review

(2015) Darrell G. Boychuk et al.   Journal of Oral & Facial Pain and Headache

Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis

(2014) Shin Fukuda et al.   BMC MUSCULOSKELETAL DISORDERS

Cellular approaches to the interaction between cannabinoid receptor ligands and nicotinic acetylcholine receptors

(2014) Murat Oz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Peripheral gating of pain signals by endogenous lipid mediators

(2014) Daniele Piomelli et al.   NATURE NEUROSCIENCE

Therapeutic Potential of Inhibitors of Endocannabinoid Degradation for the Treatment of Stress-Related Hyperalgesia in an Animal Model of Chronic Pain

(2014) Ermelinda Lomazzo et al.   NEUROPSYCHOPHARMACOLOGY

Adverse Health Effects of Marijuana Use

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations

(2014) Jennifer S. Gewandter et al.   PAIN

Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models

(2014) Travis W. Grim et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Inhibition of Fatty Acid Binding Proteins Elevates Brain Anandamide Levels and Produces Analgesia

(2014) Martin Kaczocha et al.   PLoS One

Control of synaptic function by endocannabinoid-mediated retrograde signaling

(2014) Masanobu KANO   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Legalization of Medical Marijuana and Incidence of Opioid Mortality

(2014) Marie J. Hayes et al.   JAMA Internal Medicine

DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale

(2013) Deborah S. Hasin et al.   AMERICAN JOURNAL OF PSYCHIATRY

Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1Areceptors without diminishing nervous system function or chemotherapy efficacy

(2013) Sara Jane Ward et al.   BRITISH JOURNAL OF PHARMACOLOGY

In vivocharacterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects

(2013) B M Ignatowska-Jankowska et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Subjective Psychoactive Effects of Oral Dronabinol Studied in a Randomized, Controlled Crossover Clinical Trial for Pain

(2013) Mohammed A. Issa et al.   CLINICAL JOURNAL OF PAIN

A Systematic Review of Pharmacological Pain Management in Multiple Sclerosis

(2013) Rachel Jawahar et al.   DRUGS

Cannabinoids

(2013) Paul Howard et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Colorado Family Physicians' Attitudes Toward Medical Marijuana

(2013) E. Kondrad et al.   Journal of the American Board of Family Medicine

Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides

(2013) J. Fichna et al.   NEUROGASTROENTEROLOGY AND MOTILITY

More surprises lying ahead. The endocannabinoids keep us guessing

(2013) Daniele Piomelli   NEUROPHARMACOLOGY

Cannabinoid and opioid interactions: Implications for opiate dependence and withdrawal

(2013) J.L. Scavone et al.   NEUROSCIENCE

Medical Consequences of Marijuana Use: A Review of Current Literature

(2013) Adam J. Gordon et al.   Current Psychiatry Reports

Involvement of the peroxisome proliferator-activated receptor (PPAR) alpha in vascular response of endocannabinoids in the bovine ophthalmic artery

(2012) Maria Rosaria Romano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors

(2012) Wei Xiong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of 5-HT3 receptors-activated currents by cannabinoids in rat trigeminal ganglion neurons

(2012) Bo Shi et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Sativex long-term use: an open-label trial in patients with spasticity due to multiple sclerosis

(2012) Michael G. Serpell et al.   JOURNAL OF NEUROLOGY

Cannabinoid Type-1 Receptor Reduces Pain and Neurotoxicity Produced by Chemotherapy

(2012) I. A. Khasabova et al.   JOURNAL OF NEUROSCIENCE

Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial

(2012) Russell K. Portenoy et al.   JOURNAL OF PAIN

Low-Dose Vaporized Cannabis Significantly Improves Neuropathic Pain

(2012) Barth Wilsey et al.   JOURNAL OF PAIN

An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics

(2012) Jeremy R. Johnson et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Intrathecal cannabilactone CB2R agonist, AM1710, controls pathological pain and restores basal cytokine levels

(2012) Jenny L. Wilkerson et al.   PAIN

An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee

(2012) John P. Huggins et al.   PAIN

Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system

(2012) K. Starowicz et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Polypharmacology: drug discovery for the future

(2012) A Srinivas Reddy et al.   Expert Review of Clinical Pharmacology

CB1 and CB2 receptor agonists promote analgesia through synergy in a murine model of tumor pain

(2011) Iryna A. Khasabova et al.   BEHAVIOURAL PHARMACOLOGY

Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials

(2011) Mary E. Lynch et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

(2011) Ethan B Russo   BRITISH JOURNAL OF PHARMACOLOGY

TRPV1-Dependent and -Independent Alterations in the Limbic Cortex of Neuropathic Mice: Impact on Glial Caspases and Pain Perception

(2011) Catia Giordano et al.   CEREBRAL CORTEX

A Randomized, Controlled Study to Investigate the Analgesic Efficacy of Single Doses of the Cannabinoid Receptor-2 Agonist GW842166, Ibuprofen or Placebo in Patients With Acute Pain Following Third Molar Tooth Extraction

(2011) Thor Ostenfeld et al.   CLINICAL JOURNAL OF PAIN

Cannabinoid–Opioid Interaction in Chronic Pain

(2011) D I Abrams et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

(2011) K. Ahn et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia

(2011) Wei Xiong et al.   Nature Chemical Biology

Spinal anandamide produces analgesia in neuropathic rats: Possible CB1- and TRPV1-mediated mechanisms

(2011) K. Starowicz et al.   NEUROPHARMACOLOGY

Coanalgesics for Chronic Pain Therapy: A Narrative Review

(2011) Matthew J. Bair et al.   POSTGRADUATE MEDICINE

The major central endocannabinoid directly acts at GABAA receptors

(2011) E. Sigel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats

(2010) Gin C Hsieh et al.   BRITISH JOURNAL OF PHARMACOLOGY

CB2: a cannabinoid receptor with an identity crisis

(2010) Brady K Atwood et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of cannabinoids and cannabinoid-enrichedCannabisextracts on TRP channels and endocannabinoid metabolic enzymes

(2010) Luciano De Petrocellis et al.   BRITISH JOURNAL OF PHARMACOLOGY

EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision

(2010) N. Attal et al.   EUROPEAN JOURNAL OF NEUROLOGY

Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibitors Produce Anti-Allodynic Effects in Mice Through Distinct Cannabinoid Receptor Mechanisms

(2010) Steven G. Kinsey et al.   JOURNAL OF PAIN

Cannabinoid-Mediated Modulation of Neuropathic Pain and Microglial Accumulation in a Model of Murine Type I Diabetic Peripheral Neuropathic Pain

(2010) Cory C Toth et al.   Molecular Pain

Monoacylglycerol Lipase Activity Is a Critical Modulator of the Tone and Integrity of the Endocannabinoid System

(2010) P. K. Chanda et al.   MOLECULAR PHARMACOLOGY

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism

(2010) Jason R Clapper et al.   NATURE NEUROSCIENCE

The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects

(2010) Steven G. Kinsey et al.   NEUROPHARMACOLOGY

A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of inflammatory and neuropathic pain

(2010) Xiao Hong Yu et al.   PAIN

Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis

(2010) Niklas Schuelert et al.   PAIN

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Inhibitors of Endocannabinoid-Metabolizing Enzymes Reduce Precipitated Withdrawal Responses in THC-Dependent Mice

(2009) Joel E. Schlosburg et al.   AAPS Journal

Lack of Analgesia by Oral Standardized Cannabis Extract on Acute Inflammatory Pain and Hyperalgesia in Volunteers

(2009) Birgit Kraft et al.   ANESTHESIOLOGY

Fentanyl Analogs: Structure-Activity-Relationship Study

(2009) S. Vuckovic et al.   CURRENT MEDICINAL CHEMISTRY

Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests

(2009) Elisa Burgos et al.   EUROPEAN JOURNAL OF PAIN

Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain

(2009) Jeremy R. Johnson et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: A neuroprotective therapeutic modality

(2009) Jeannie Hwang et al.   LIFE SCIENCES

Cannabinoids as pharmacotherapies for neuropathic pain: From the bench to the bedside

(2009) Elizabeth J. Rahn et al.   Neurotherapeutics

The Nonpsychotropic Cannabinoid Cannabidiol Modulates and Directly Activates Alpha-1 and Alpha-1-Beta Glycine Receptor Function

(2009) Jörg Ahrens et al.   PHARMACOLOGY

Spinal Endocannabinoids and CB1 Receptors Mediate C-Fiber-Induced Heterosynaptic Pain Sensitization

(2009) A. J. Pernia-Andrade et al.   SCIENCE

Targeting CB2 receptors and the endocannabinoid system for the treatment of pain

(2008) Praveen Anand et al.   BRAIN RESEARCH REVIEWS

Biomarkers for the effects of cannabis and THC in healthy volunteers

(2008) Lineke Zuurman et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Inhibition of fatty acid amide hydrolase produces PPAR-α-mediated analgesia in a rat model of inflammatory pain

(2008) D R Sagar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adverse effects of medical cannabinoids: a systematic review

(2008) T. Wang et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain

(2008) Wataru Yamamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Decrease in Anandamide Signaling Contributes to the Maintenance of Cutaneous Mechanical Hyperalgesia in a Model of Bone Cancer Pain

(2008) I. A. Khasabova et al.   JOURNAL OF NEUROSCIENCE

Interferon-  Is a Critical Modulator of CB2 Cannabinoid Receptor Signaling during Neuropathic Pain

(2008) I. Racz et al.   JOURNAL OF NEUROSCIENCE

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

Peripheral cannabinoids attenuate carcinoma-induced nociception in mice

(2008) Andre V. Guerrero et al.   NEUROSCIENCE LETTERS

The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain

(2008) Penny C. Staton et al.   PAIN

Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved

(2008) Francesca Comelli et al.   PHYTOTHERAPY RESEARCH

The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin

(2007) R G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats

(2007) E J Rahn et al.   BRITISH JOURNAL OF PHARMACOLOGY

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

(2007) A Thomas et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of TRPV1 receptors in the antinociceptive effect of anandamide at spinal level

(2007) Gyöngyi Horvath et al.   PAIN