Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling

Epidermal Growth Factor Receptor Signaling Disruption by Endocrine and Metabolic Disrupting Chemicals

(2018) Josiah E Hardesty et al.   TOXICOLOGICAL SCIENCES

Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation

(2017) Jan Dusek et al.   FOOD AND CHEMICAL TOXICOLOGY

Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation

(2017) Ryota Shizu et al.   MOLECULAR AND CELLULAR BIOLOGY

Polychlorinated biphenyls disrupt hepatic epidermal growth factor receptor signaling

(2017) Josiah E. Hardesty et al.   XENOBIOTICA

Mechanisms of xenobiotic receptor activation: Direct vs. indirect

(2016) Bryan Mackowiak et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor

(2016) Lushan Yu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Small-molecule modulators of PXR and CAR

(2016) Sergio C. Chai et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for (“squelching”) SRC-1 coactivator

(2016) Lucie Hyrsova et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?

(2016) Luigi Sapio et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells

(2015) Daochuan Li et al.   BIOCHEMICAL PHARMACOLOGY

CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α

(2015) Jie Gao et al.   MOLECULAR ENDOCRINOLOGY

The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists

(2015) Alejandro Carazo et al.   SENSORS

Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR)

(2015) Alejandro Carazo Fernández et al.   TOXICOLOGY LETTERS

Deciphering the roles of the constitutive androstane receptor in energy metabolism

(2014) Jiong Yan et al.   ACTA PHARMACOLOGICA SINICA

CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis

(2014) Kyoung-Jin Oh et al.   BMB Reports

Safety evaluation of leflunomide in rheumatoid arthritis

(2013) Helen I Keen et al.   Expert Opinion On Drug Safety

Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling

(2013) S. Mutoh et al.   Science Signaling

The constitutive androstane receptor activator 4-[(4R,6R)-4,6-diphenyl-1,3-dioxan-2-yl]-N,N-dimethylaniline inhibits the gluconeogenic genesPEPCKandG6Pasethrough the suppression of HNF4α and FOXO1 transcriptional activity

(2012) AA Yarushkin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of Novel Activators of Constitutive Androstane Receptor from FDA-Approved Drugs by Integrated Computational and Biological Approaches

(2012) Caitlin Lynch et al.   PHARMACEUTICAL RESEARCH

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

(2011) Lucie Krausova et al.   BIOCHEMICAL PHARMACOLOGY

Active ERK1/2 Protein Interacts with the Phosphorylated Nuclear Constitutive Active/Androstane Receptor (CAR; NR1I3), Repressing Dephosphorylation and Sequestering CAR in the Cytoplasm

(2011) Makoto Osabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes

(2010) A. RULCOVA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers

(2009) Tadeja Režen et al.   BMC GENOMICS

Nuclear Translocation of Adenoviral-Enhanced Yellow Fluorescent Protein-Tagged-Human Constitutive Androstane Receptor (hCAR): A Novel Tool for Screening hCAR Activators in Human Primary Hepatocytes

(2009) H. Li et al.   DRUG METABOLISM AND DISPOSITION

Methadone Induces the Expression of Hepatic Drug-Metabolizing Enzymes through the Activation of Pregnane X Receptor and Constitutive Androstane Receptor

(2009) A. H. Tolson et al.   DRUG METABOLISM AND DISPOSITION

The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

(2009) Jie Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)

(2009) Shingo Mutoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor (CAR) 1 to the Xenobiotic-Sensitive Splicing Variant CAR3

(2009) T. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

(2009) Alessandra di Masi et al.   MOLECULAR ASPECTS OF MEDICINE

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

(2009) B. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA