Snake Venom Peptides: Tools of Biodiscovery

Peptide therapeutics from venom: Current status and potential

(2018) Michael W. Pennington et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives

(2018) Rodrigo Simoes-Silva et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms

(2018) Stuart Ainsworth et al.   Journal of Proteomics

Co-Localization of Crotamine with Internal Membranes and Accentuated Accumulation in Tumor Cells

(2018) Nicole Mambelli-Lisboa et al.   MOLECULES

First Look at the Venom of Naja ashei

(2018) Konrad Hus et al.   MOLECULES

A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP + toxicity by activating the NGF-signaling pathway

(2018) Carolina P. Bernardes et al.   PEPTIDES

Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity

(2018) Andrea Sala et al.   PLoS One

Snake Venom As An Effective Tool Against Colorectal Cancer

(2018) Bushra Uzair et al.   PROTEIN AND PEPTIDE LETTERS

Simulation Studies and Dynamic Interaction of Venom Peptides with ion Channels

(2018) Naqab Khan et al.   PROTEIN AND PEPTIDE LETTERS

Accelerated evolution of toxin genes: Exonization and intronization in snake venom disintegrin/metalloprotease genes

(2018) R. Manjunatha Kini   TOXICON

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

(2018) Julien Slagboom et al.   TOXICON

Mechanistic insights into functional characteristics of native crotamine

(2018) Daniel Batista da Cunha et al.   TOXICON

Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins

(2018) Kenia Lourenço Vanzolini et al.   TOXICON

Pharmacokinetics of Snake Venom

(2018) Suchaya Sanhajariya et al.   Toxins

Integrin Inhibitors in Prostate Cancer

(2018) Maylein Juan-Rivera et al.   Cancers

New insights into the proteomic characterization of the coral snake Micrurus pyrrhocryptus venom

(2018) Timoteo Olamendi-Portugal et al.   TOXICON

Pharmacological characterization of crotamine effects on mice hind limb paralysis employing both ex vivo and in vivo assays: Insights into the involvement of voltage-gated ion channels in the crotamine action on skeletal muscles

(2018) Sunamita de Carvalho Lima et al.   PLoS Neglected Tropical Diseases

Recombinant and Chimeric Disintegrins in Preclinical Research

(2018) Victor David et al.   Toxins

Application of Metabolomic Tools for Studying Low Molecular-Weight Fraction of Animal Venoms and Poisons

(2018) Agnieszka Klupczynska et al.   Toxins

Delineating residues for haemolytic activities of snake venom cardiotoxin 1 from Naja naja as probed by molecular dynamics simulations and in vitro validations

(2017) Biswajit Gorai et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions

(2017) Pascal Kessler et al.   JOURNAL OF NEUROCHEMISTRY

Venom proteome of the yellow-lipped sea krait, Laticauda colubrina from Bali: Insights into subvenomic diversity, venom antigenicity and cross-neutralization by antivenom

(2017) Choo Hock Tan et al.   Journal of Proteomics

Venomics of Bungarus caeruleus (Indian krait): Comparable venom profiles, variable immunoreactivities among specimens from Sri Lanka, India and Pakistan

(2017) Angeline Mei Feng Oh et al.   Journal of Proteomics

Proteomic analysis to unravel the complex venom proteome of eastern India Naja naja: Correlation of venom composition with its biochemical and pharmacological properties

(2017) Sumita Dutta et al.   Journal of Proteomics

Gene design, fusion technology and TEV cleavage conditions influence the purification of oxidized disulphide-rich venom peptides in Escherichia coli

(2017) Ana Filipa Sequeira et al.   Microbial Cell Factories

High-throughput expression of animal venom toxins in Escherichia coli to generate a large library of oxidized disulphide-reticulated peptides for drug discovery

(2017) Jeremy Turchetto et al.   Microbial Cell Factories

Venom-derived peptide inhibitors of voltage-gated potassium channels

(2017) Raymond S. Norton et al.   NEUROPHARMACOLOGY

Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms

(2017) Sébastien Dutertre et al.   NEUROPHARMACOLOGY

Pathophysiological significance and therapeutic applications of snake venom protease inhibitors

(2017) Rupamoni Thakur et al.   TOXICON

Targeting Metastasis with Snake Toxins: Molecular Mechanisms

(2017) Félix Urra et al.   Toxins

A Review and Database of Snake Venom Proteomes

(2017) Theo Tasoulis et al.   Toxins

Venomics of Tropidolaemus wagleri, the sexually dimorphic temple pit viper: Unveiling a deeply conserved atypical toxin arsenal

(2017) Choo Hock Tan et al.   Scientific Reports

The characterization of trans-pecos copperhead ( Agkistrodon contortrix pictigaster ) venom and isolation of two new dimeric disintegrins

(2016) Sara Lucena et al.   BIOLOGICALS

Purification and characterization of tenerplasminin-1, a serine peptidase inhibitor with antiplasmin activity from the coral snake ( Micrurus tener tener ) venom

(2016) Jeilyn Vivas et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Trends in the Evolution of Snake Toxins Underscored by an Integrative Omics Approach to Profile the Venom of the ColubridPhalotris mertensi

(2016) Pollyanna Fernandes Campos et al.   Genome Biology and Evolution

Viper Venom Botox: The Molecular Origin and Evolution of the Waglerin Peptides Used in Anti-Wrinkle Skin Cream

(2016) Jordan Debono et al.   JOURNAL OF MOLECULAR EVOLUTION

α-Dendrotoxin-sensitive Kv1 channels contribute to conduction failure of polymodal nociceptive C-fibers from rat coccygeal nerve

(2016) Xiu-Chao Wang et al.   JOURNAL OF NEUROPHYSIOLOGY

Proteomic characterization and comparison of venoms from two elapid snakes (Bungarus multicinctus and Naja atra) from China

(2016) Lin-Lin Shan et al.   Journal of Proteomics

A proteomic analysis of Pakistan Daboia russelii russelii venom and assessment of potency of Indian polyvalent and monovalent antivenom

(2016) Ashis K. Mukherjee et al.   Journal of Proteomics

Toxicovenomics and antivenom profiling of the Eastern green mamba snake ( Dendroaspis angusticeps )

(2016) Line P. Lauridsen et al.   Journal of Proteomics

Top-down venomics of the East African green mamba, Dendroaspis angusticeps , and the black mamba, Dendroaspis polylepis , highlight the complexity of their toxin arsenals

(2016) Daniel Petras et al.   Journal of Proteomics

Discovery and characterisation of a novel toxin from Dendroaspis angusticeps, named Tx7335, that activates the potassium channel KcsA

(2016) Iván O. Rivera-Torres et al.   Scientific Reports

Respiratory Effects of Sarafotoxins from the Venom of Different Atractaspis Genus Snake Species

(2016) Stéphanie Malaquin et al.   Toxins

The Snake with the Scorpion’s Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus)

(2016) Daryl Yang et al.   Toxins

Snake Venom Metalloproteinases and Their Peptide Inhibitors from Myanmar Russell’s Viper Venom

(2016) Khin Yee et al.   Toxins

Venom of the Coral Snake Micrurus clarki: Proteomic Profile, Toxicity, Immunological Cross-Neutralization, and Characterization of a Three-Finger Toxin

(2016) Bruno Lomonte et al.   Toxins

Venomic Analysis of the Poorly Studied Desert Coral Snake, Micrurus tschudii tschudii, Supports the 3FTx/PLA2 Dichotomy across Micrurus Venoms

(2016) Libia Sanz et al.   Toxins

Proteomic Characterization and Comparison of Malaysian Tropidolaemus wagleri and Cryptelytrops purpureomaculatus Venom Using Shotgun-Proteomics

(2016) Syafiq Zainal Abidin et al.   Toxins

Lebetin 2, a Snake Venom-Derived Natriuretic Peptide, Attenuates Acute Myocardial Ischemic Injury through the Modulation of Mitochondrial Permeability Transition Pore at the Time of Reperfusion

(2016) Bochra Tourki et al.   PLoS One

A Distinct Functional Site in Ω-Neurotoxins: Novel Antagonists of Nicotinic Acetylcholine Receptors from Snake Venom

(2015) Varuna Hassan-Puttaswamy et al.   ACS Chemical Biology

A Defined α-Helix in the BifunctionalO-Glycosylated Natriuretic Peptide TcNPa from the Venom ofTropidechis carinatus

(2015) Timothy Reeks et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tail wags the dog: activity of krait natriuretic peptide is determined by its C-terminal tail in a natriuretic peptide receptor-independent manner

(2015) Sindhuja Sridharan et al.   BIOCHEMICAL JOURNAL

Disintegrins of Crotalus simus tzabcan venom: Isolation, characterization and evaluation of the cytotoxic and anti-adhesion activities of tzabcanin, a new RGD disintegrin

(2015) Anthony J. Saviola et al.   BIOCHIMIE

Disintegrins from Snake Venoms and their Applications in Cancer Research and Therapy

(2015) Jessica Arruda Macedo et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Hypotensive Peptides from Snake Venoms: Structure, Function and Mechanism

(2015) Xiaolong Xu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Antiplatelet Aggregation and Antithrombosis Efficiency of Peptides in the Snake Venom ofDeinagkistrodon acutus: Isolation, Identification, and Evaluation

(2015) Bin Ding et al.   Evidence-based Complementary and Alternative Medicine

Neurotoxin from Naja naja atra venom inhibits skin allograft rejection in rats

(2015) Yin-Li Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cardiotoxin III Inhibits Hepatocyte Growth Factor-Induced Epithelial-Mesenchymal Transition and Suppresses Invasion of MDA-MB-231 Cells

(2015) Pei-Chien Tsai et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Purification and Characterization of Nk-3FTx: A Three Finger Toxin from the Venom of North East Indian Monocled Cobra

(2015) Diganta Das et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Structural Insight into Specificity of Interactions between Nonconventional Three-finger Weak Toxin fromNaja kaouthia(WTX) and Muscarinic Acetylcholine Receptors

(2015) Ekaterina N. Lyukmanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigation of Congenital Myasthenia Reveals Functional Asymmetry of Invariant Acetylcholine Receptor (AChR) Cys-loop Aspartates

(2015) Xin-Ming Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition

(2015) Gilles Mourier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa

(2015) Yi Kong et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: Identification of key toxin targets for antivenom development

(2015) Andreas H. Laustsen et al.   Journal of Proteomics

Cobra venom cytotoxins; apoptotic or necrotic agents?

(2015) Karim Ebrahim et al.   TOXICON

Quantitative proteomic analysis of Vietnamese krait venoms: Neurotoxins are the major components in Bungarus multicinctus and phospholipases A2 in Bungarus fasciatus

(2015) Rustam H. Ziganshin et al.   TOXICON

Venomics of the Australian eastern brown snake ( Pseudonaja textilis ): Detection of new venom proteins and splicing variants

(2015) Vincent Louis Viala et al.   TOXICON

Short- versus Long-Sarafotoxins: Two Structurally Related Snake Toxins with Very Different in vivo Haemodynamic Effects

(2015) Yazine Mahjoub et al.   PLoS One

Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers

(2014) C. B. Falcao et al.   AMINO ACIDS

Isolation and Structural and Pharmacological Characterization of α-Elapitoxin-Dpp2d, an Amidated Three Finger Toxin from Black Mamba Venom

(2014) Ching-I Anderson Wang et al.   BIOCHEMISTRY

Natriuretic peptides and cardio-renal disease

(2014) Massimo Volpe   INTERNATIONAL JOURNAL OF CARDIOLOGY

Proteomic characterization and comparison of Malaysian Bungarus candidus and Bungarus fasciatus venoms

(2014) Muhamad Rusdi Ahmad Rusmili et al.   Journal of Proteomics

Vintage venoms: Proteomic and pharmacological stability of snake venoms stored for up to eight decades

(2014) Clémence Jesupret et al.   Journal of Proteomics

PIVL, a snake venom Kunitz-type serine protease inhibitor, inhibits in vitro and in vivo angiogenesis

(2014) Maram Morjen et al.   MICROVASCULAR RESEARCH

Pharmacological properties and pathophysiological significance of a Kunitz-type protease inhibitor (Rusvikunin-II) and its protein complex (Rusvikunin complex) purified from Daboia russelii russelii venom

(2014) Ashis K. Mukherjee et al.   TOXICON

Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails

(2014) Sébastien Dutertre et al.   Nature Communications

Utilisation of adsorption and desorption for simultaneously improving protein crystallisation success rate and crystal quality

(2014) Yun-Zhu Guo et al.   Scientific Reports

Elapid Snake Venom Analyses Show the Specificity of the Peptide Composition at the Level of Genera Naja and Notechis

(2014) Aisha Munawar et al.   Toxins

State of the Art in the Studies on Crotamine, a Cell Penetrating Peptide from South American Rattlesnake

(2014) Irina Kerkis et al.   Biomed Research International

Structure of the polypeptide crotamine from the Brazilian rattlesnakeCrotalus durissus terrificus

(2013) Monika A. Coronado et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cobra Cardiotoxins: Membrane Interactions and Pharmacological Potential

(2013) P. Dubovskii et al.   CURRENT MEDICINAL CHEMISTRY

BF9, the First Functionally Characterized Snake Toxin Peptide with Kunitz-Type Protease and Potassium Channel Inhibiting Properties

(2013) Weishan Yang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Functional characterization on invertebrate and vertebrate tissues of tachykinin peptides from octopus venoms

(2013) Tim Ruder et al.   PEPTIDES

Proline rich-oligopeptides: Diverse mechanisms for antihypertensive action

(2013) Katia L.P. Morais et al.   PEPTIDES

The structure of Human Microplasmin in Complex with Textilinin-1, an Aprotinin-like Inhibitor from the Australian Brown Snake

(2013) Emma-Karin I. Millers et al.   PLoS One

Thrombolytic Effects of the Snake Venom Disintegrin Saxatilin Determined by Novel Assessment Methods: A FeCl3-Induced Thrombosis Model in Mice

(2013) Il Kwon et al.   PLoS One

Analytical workflow for rapid screening and purification of bioactives from venom proteomes

(2013) Reka A. Otvos et al.   TOXICON

Three-Fingered RAVERs: Rapid Accumulation of Variations in Exposed Residues of Snake Venom Toxins

(2013) Kartik Sunagar et al.   Toxins

Single-drop optimization of protein crystallization

(2012) Arne Meyer et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Structure and Dynamics of Cardiotoxins

(2012) Anastasia G. Konshina et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone system inhibitors involving 158 998 patients

(2012) L. C. van Vark et al.   EUROPEAN HEART JOURNAL

Dimeric α-Cobratoxin X-ray Structure

(2012) Alexey V. Osipov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIVL, a new serine protease inhibitor from Macrovipera lebetina transmediterranea venom, impairs motility of human glioblastoma cells

(2012) Maram Morjen et al.   MATRIX BIOLOGY

Black mamba venom peptides target acid-sensing ion channels to abolish pain

(2012) Sylvie Diochot et al.   NATURE

Monitoring and Scoring Counter-Diffusion Protein Crystallization Experiments in Capillaries by in situ Dynamic Light Scattering

(2012) Dominik Oberthuer et al.   PLoS One

Identification and Structural Characterization of a New Three-Finger Toxin Hemachatoxin from Hemachatus haemachatus Venom

(2012) Vallerinteavide Mavelli Girish et al.   PLoS One

The continuing saga of snake venom disintegrins

(2012) Juan J. Calvete   TOXICON

Three-finger toxins, a deadly weapon of elapid venom – Milestones of discovery

(2012) Yuri N. Utkin   TOXICON

Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides

(2012) Geoffrey Masuyer et al.   Scientific Reports

Neurological complications of venomous snake bites: a review

(2011) O. H. Del Brutto et al.   ACTA NEUROLOGICA SCANDINAVICA

Identification and characterisation of Kunitz-type plasma kallikrein inhibitors unique to Oxyuranus sp. snake venoms

(2011) Stephen T.H. Earl et al.   BIOCHIMIE

Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension

(2011) Gilles Mourier et al.   BIOCHIMIE

Venoms as a platform for human drugs: translating toxins into therapeutics

(2011) Glenn F King   EXPERT OPINION ON BIOLOGICAL THERAPY

Crotamine toxicity and efficacy in mouse models of melanoma

(2011) Alexandre Pereira et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Venom peptide analysis of Vipera ammodytes meridionalis (Viperinae) and Bothrops jararacussu (Crotalinae) demonstrates subfamily-specificity of the peptidome in the family Viperidae

(2011) Aisha Munawar et al.   Molecular BioSystems

Non-RGD-containing snake venom disintegrins, functional and structural relations

(2011) Erin M. Walsh et al.   TOXICON

From snake venom toxins to therapeutics – Cardiovascular examples

(2011) Cho Yeow Koh et al.   TOXICON

“Anatomical” View of the Protein Composition and Protein Characteristics for Gloydius shedaoensis Snake Venom via Proteomics Approach

(2010) Shuqing Liu et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom ofOphiophagus hannah(King Cobra)

(2010) Amrita Roy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanism of δ-dendrotoxin-potassium channel recognition explored by docking and molecular dynamic simulations

(2010) Ling Jin et al.   JOURNAL OF MOLECULAR RECOGNITION

Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography

(2010) James R. Banigan et al.   PROTEIN SCIENCE

Venom on ice: First insights into Antarctic octopus venoms

(2010) E.A.B. Undheim et al.   TOXICON

Structure, function and evolution of three-finger toxins: Mini proteins with multiple targets

(2010) R. Manjunatha Kini et al.   TOXICON

A novel natriuretic peptide from the cobra venom

(2010) Yong Zhang et al.   TOXICON

Natriuretic peptide drug leads from snake venom

(2010) S. Vink et al.   TOXICON

Drug development from Australian elapid snake venoms and the Venomics pipeline of candidates for haemostasis: Textilinin-1 (Q8008), Haempatch™ (Q8009) and CoVase™ (V0801)

(2010) Stephen T.H. Earl et al.   TOXICON

Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss

(2009) Simone M. Flight et al.   BRITISH JOURNAL OF HAEMATOLOGY

Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis)

(2009) Emma-Karin I. Millers et al.   FEBS Journal

Common evolution of waprin and kunitz-like toxin families in Australian venomous snakes

(2008) L. St Pierre et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Proteome analysis of snake venom toxins: pharmacological insights

(2008) Dessislava Georgieva et al.   Expert Review of Proteomics

Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity

(2008) Joanna Pawlak et al.   FASEB JOURNAL

Evolution of Snake Venom Disintegrins by Positive Darwinian Selection

(2008) P. Juarez et al.   MOLECULAR BIOLOGY AND EVOLUTION

Molecular characterisation of endogenous snake venom metalloproteinase inhibitors

(2007) Simon C. Wagstaff et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS