The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions

Cholinergic system and cell proliferation

(2016) F.J. Campoy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Toxicovenomics and antivenom profiling of the Eastern green mamba snake ( Dendroaspis angusticeps )

(2016) Line P. Lauridsen et al.   Journal of Proteomics

Central loop of non-conventional toxin WTX from Naja kaouthia is important for interaction with nicotinic acetylcholine receptors

(2016) Ekaterina N. Lyukmanova et al.   TOXICON

Discovery and characterisation of a novel toxin from Dendroaspis angusticeps, named Tx7335, that activates the potassium channel KcsA

(2016) Iván O. Rivera-Torres et al.   Scientific Reports

Venomic Analysis of the Poorly Studied Desert Coral Snake, Micrurus tschudii tschudii, Supports the 3FTx/PLA2 Dichotomy across Micrurus Venoms

(2016) Libia Sanz et al.   Toxins

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor

(2016) Ekaterina N. Lyukmanova et al.   PLoS One

Structural Insight into Specificity of Interactions between Nonconventional Three-finger Weak Toxin fromNaja kaouthia(WTX) and Muscarinic Acetylcholine Receptors

(2015) Ekaterina N. Lyukmanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition

(2015) Gilles Mourier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multidimensional Drift of Sequence Attributes and Functional Profiles in the Superfamily of the Three-Finger Proteins and Their Structural Homologues

(2015) Andrzej Galat   Journal of Chemical Information and Modeling

MmTX1 and MmTX2 from coral snake venom potently modulate GABAAreceptor activity

(2015) Jean-Pierre Rosso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-finger snake neurotoxins and Ly6 proteins targeting nicotinic acetylcholine receptors: pharmacological tools and endogenous modulators

(2015) Victor I. Tsetlin   TRENDS IN PHARMACOLOGICAL SCIENCES

Lynx1 Shifts α4β2 Nicotinic Receptor Subunit Stoichiometry by Affecting Assembly in the Endoplasmic Reticulum

(2014) Weston A. Nichols et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain

(2014) Marios Zouridakis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera

(2013) Sun Huang et al.   BIOCHEMICAL JOURNAL

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system

(2013) F. J. Vonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-Fingered RAVERs: Rapid Accumulation of Variations in Exposed Residues of Snake Venom Toxins

(2013) Kartik Sunagar et al.   Toxins

Black mamba venom peptides target acid-sensing ion channels to abolish pain

(2012) Sylvie Diochot et al.   NATURE

Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors

(2012) Carole Fruchart-Gaillard et al.   PLoS One

Enhancement in Motor Learning through Genetic Manipulation of the Lynx1 Gene

(2012) Julie M. Miwa et al.   PLoS One

Structural Model of Ligand-G Protein-coupled Receptor (GPCR) Complex Based on Experimental Double Mutant Cycle Data

(2011) Catherine Marquer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Snake Cytotoxins Bind to Membranes via Interactions with Phosphatidylserine Head Groups of Lipids

(2011) Anastasia G. Konshina et al.   PLoS One

Localization of pre- and postsynaptic cholinergic markers in rodent forebrain: A brief history and comparison of rat and mouse

(2010) E.A. Van der Zee et al.   BEHAVIOURAL BRAIN RESEARCH

The cholinergic system and spatial learning

(2010) Serena Deiana et al.   BEHAVIOURAL BRAIN RESEARCH

Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2-adrenoceptors

(2010) Céline Rouget et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lynx1, a Cholinergic Brake, Limits Plasticity in Adult Visual Cortex

(2010) H. Morishita et al.   SCIENCE

Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the α1A-adrenoceptor

(2009) L Quinton et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prostate Stem Cell Antigen Is an Endogenous lynx1-Like Prototoxin That Antagonizes  7-Containing Nicotinic Receptors and Prevents Programmed Cell Death of Parasympathetic Neurons

(2009) M. Hruska et al.   JOURNAL OF NEUROSCIENCE

Expression of SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells

(2009) Kazuhide Horiguchi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Unusual accelerated rate of deletions and insertions in toxin genes in the venom glands of the pygmy copperhead (Austrelaps labialis) from kangaroo island

(2008) Robin Doley et al.   BMC EVOLUTIONARY BIOLOGY

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

(2008) I Wessler et al.   BRITISH JOURNAL OF PHARMACOLOGY

The three-fingered protein domain of the human genome

(2008) A. Galat   CELLULAR AND MOLECULAR LIFE SCIENCES

Acetylcholinesterase: How is structure related to function?

(2008) Israel Silman et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity

(2008) Joanna Pawlak et al.   FASEB JOURNAL

PATEGene Clusters Code for Multiple, Secreted TFP/Ly-6/uPAR Proteins That Are Expressed in Reproductive and Neuron-rich Tissues and Possess Neuromodulatory Activity

(2008) Fiana Levitin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY