Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration

Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice

(2018) Hui Li et al.   PLoS Pathogens

Effect of low-to-moderate-dose corticosteroids on mortality of hospitalized adolescents and adults with influenza A(H1N1)pdm09 viral pneumonia

(2017) Hui Li et al.   Influenza and Other Respiratory Viruses

The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia

(2017) Jing Huang et al.   Innate Immunity

Inorganic polyphosphate: a key modulator of inflammation

(2017) S. M. Hassanian et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Rapamycin adjuvant and exacerbation of severe influenza in an experimental mouse model

(2017) Ching-Tai Huang et al.   Scientific Reports

Targeting Metabolic Reprogramming by Influenza Infection for Therapeutic Intervention

(2017) Heather S. Smallwood et al.   Cell Reports

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication

(2017) Sharon K. Kuss-Duerkop et al.   PLoS Pathogens

Placental Growth Factor Contributes to Liver Inflammation, Angiogenesis, Fibrosis in Mice by Promoting Hepatic Macrophage Recruitment and Activation

(2017) Xi Li et al.   Frontiers in Immunology

Vγ4+γδT Cells Aggravate Severe H1N1 Influenza Virus Infection-Induced Acute Pulmonary Immunopathological Injury via Secreting Interleukin-17A

(2017) Chunxue Xue et al.   Frontiers in Immunology

Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection

(2017) Bria M. Coates et al.   Frontiers in Immunology

Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury

(2016) Yue Hu et al.   Autophagy

Cellular and molecular regulation of innate inflammatory responses

(2016) Juan Liu et al.   Cellular & Molecular Immunology

Adjuvant Corticosteroid Treatment in Adults With Influenza A (H7N9) Viral Pneumonia*

(2016) Bin Cao et al.   CRITICAL CARE MEDICINE

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

(2016) V. Martínez-Cisuelo et al.   EXPERIMENTAL GERONTOLOGY

PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome

(2016) Anita Pinar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hero turned villain: NLRP3 inflammasome-induced inflammation during influenza A virus infection

(2016) James D. H. Ong et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Amelioration of salvianolic acid C on aortic structure in apolipoprotein E-deficient mice treated with angiotension II

(2016) Peng Wu et al.   LIFE SCIENCES

Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A

(2016) Chong Xu et al.   NEUROPHARMACOLOGY

The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation

(2016) Tomohiro Okamoto et al.   PLoS One

Rapamycin Does Not Impede Survival or Induction of Antibody Responses to Primary and Heterosubtypic Influenza Infections in Mice

(2016) Justine S. Liepkalns et al.   VIRAL IMMUNOLOGY

A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection

(2016) Te-Chen Tzeng et al.   Cell Reports

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

(2016) Michelle D. Tate et al.   Scientific Reports

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Influenza virus-induced lung injury: pathogenesis and implications for treatment

(2015) Susanne Herold et al.   EUROPEAN RESPIRATORY JOURNAL

Neuraminidase inhibitors, superinfection and corticosteroids affect survival of influenza patients

(2015) Nelson Lee et al.   EUROPEAN RESPIRATORY JOURNAL

Inorganic polyphosphate elicits pro-inflammatory responses through activation of the mammalian target of rapamycin complexes 1 and 2 in vascular endothelial cells

(2015) S. M. Hassanian et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Comparison of Patients Hospitalized With Influenza A Subtypes H7N9, H5N1, and 2009 Pandemic H1N1

(2014) Chen Wang et al.   CLINICAL INFECTIOUS DISEASES

Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options

(2014) Alimuddin Zumla et al.   LANCET INFECTIOUS DISEASES

Early Cytokine Dysregulation and Viral Replication Are Associated with Mortality During Lethal Influenza Infection

(2014) Alexander J. Vogel et al.   VIRAL IMMUNOLOGY

Adjunctive therapies and immunomodulatory agents in the management of severe influenza

(2013) David S. Hui et al.   ANTIVIRAL RESEARCH

A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection

(2013) Marlène Brandes et al.   CELL

Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury

(2013) Wei Wang et al.   CELL RESEARCH

Adjuvant Treatment With a Mammalian Target of Rapamycin Inhibitor, Sirolimus, and Steroids Improves Outcomes in Patients With Severe H1N1 Pneumonia and Acute Respiratory Failure*

(2013) Chun-Hua Wang et al.   CRITICAL CARE MEDICINE

Pathogenesis of influenza-induced acute respiratory distress syndrome

(2013) Kirsty R Short et al.   LANCET INFECTIOUS DISEASES

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

(2013) Julien Pothlichet et al.   PLoS Pathogens

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

(2013) Julie L. McAuley et al.   PLoS Pathogens

CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral Origin

(2012) Akihiko Ichikawa et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Pathogenesis of influenza virus infections: the good, the bad and the ugly

(2012) T Kuiken et al.   Current Opinion in Virology

Corticosteroid Treatment in Critically Ill Patients with Pandemic Influenza A/H1N1 2009 Infection

(2011) Sung-Han Kim et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Early Corticosteroids in Severe Influenza A/H1N1 Pneumonia and Acute Respiratory Distress Syndrome

(2011) Christian Brun-Buisson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Therapy With m-TOR Inhibitors Decreases the Response to the Pandemic Influenza A H1N1 Vaccine in Solid Organ Transplant Recipients

(2011) E. Cordero et al.   AMERICAN JOURNAL OF TRANSPLANTATION

IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus

(2011) Chenggang Li et al.   CELL RESEARCH

The pathogenesis of influenza virus infections: the contributions of virus and host factors

(2011) Satoshi Fukuyama et al.   CURRENT OPINION IN IMMUNOLOGY

Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza

(2011) Wilbur H. Chen et al.   IMMUNOLOGY LETTERS

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor

(2011) Miguel A Mata et al.   Nature Chemical Biology

Quantitative Subcellular Proteome and Secretome Profiling of Influenza A Virus-Infected Human Primary Macrophages

(2011) Niina Lietzén et al.   PLoS Pathogens

Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China

(2010) Lu Bai et al.   CHEST

Number of Peripheral Blood Regulatory T Cells and Lymphocyte Activation at 3 Months After Conversion to mTOR Inhibitor Therapy

(2010) D. San Segundo et al.   TRANSPLANTATION PROCEEDINGS

Participation of Mammalian Target of Rapamycin Complex 1 in Toll-Like Receptor 2– and 4–Induced Neutrophil Activation and Acute Lung Injury

(2009) Emmanuel Lorne et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Viral Loads and Duration of Viral Shedding in Adult Patients Hospitalized with Influenza

(2009) Nelson Lee et al.   JOURNAL OF INFECTIOUS DISEASES

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

Clinical Features of the Initial Cases of 2009 Pandemic Influenza A (H1N1) Virus Infection in China

(2009) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK

(2008) H. C. Dan et al.   GENES & DEVELOPMENT

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus

(2008) B.-J. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA