Autophagy: A new strategy for host-directed therapy of tuberculosis

Ambroxol induces autophagy and potentiates Rifampin antimycobacterial activity

(2018) Seong Won Choi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PPAR-α Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism

(2017) Yi Sak Kim et al.   JOURNAL OF IMMUNOLOGY

Host-directed therapies for bacterial and viral infections

(2017) Stefan H. E. Kaufmann et al.   NATURE REVIEWS DRUG DISCOVERY

Mycobacterium tuberculosisis protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA

(2017) Stefan Köster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells

(2017) Subbarayalu Panneerdoss et al.   Nature Communications

Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway

(2017) Tae Sung Kim et al.   Scientific Reports

Doxycycline Induces Mitophagy and Suppresses Production of Interferon-β in IPEC-J2 Cells

(2017) Yang Xing et al.   Frontiers in Cellular and Infection Microbiology

Antimycobacterial and Anti-inflammatory Mechanisms of Baicalin via Induced Autophagy in Macrophages Infected with Mycobacterium tuberculosis

(2017) Qingwen Zhang et al.   Frontiers in Microbiology

Macrophage Autophagy and Bacterial Infections

(2017) Aïcha Bah et al.   Frontiers in Immunology

Targeted pulmonary delivery of inducers of host macrophage autophagy as a potential host-directed chemotherapy of tuberculosis

(2016) Anuradha Gupta et al.   ADVANCED DRUG DELIVERY REVIEWS

Loperamide Restricts Intracellular Growth ofMycobacterium tuberculosisin Lung Macrophages

(2016) Esmeralda Juárez et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Identification of natural products with neuronal and metabolic benefits through autophagy induction

(2016) Yuying Fan et al.   Autophagy

Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis

(2016) Alimuddin Zumla et al.   BMC Medicine

LAP: the protector against autoimmunity

(2016) Urmi Bandyopadhyay et al.   CELL RESEARCH

LC3-associated phagocytosis: a crucial mechanism for antifungal host defence againstAspergillus fumigatus

(2016) Evelien G. G. Sprenkeler et al.   CELLULAR MICROBIOLOGY

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Species-specific regulation of innate immunity by vitamin D signaling

(2016) Vassil Dimitrov et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Bacterial Pathogens versus Autophagy: Implications for Therapeutic Interventions

(2016) Jacqueline M. Kimmey et al.   TRENDS IN MOLECULAR MEDICINE

Targeting Drug-Sensitive and -Resistant Strains of Mycobacterium tuberculosis by Inhibition of Src Family Kinases Lowers Disease Burden and Pathology

(2016) Pallavi Chandra et al.   mSphere

Vitamin D as Adjunctive Host-Directed Therapy in Tuberculosis: A Systematic Review

(2016) Robert S. Wallis et al.   Open Forum Infectious Diseases

High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial

(2015) Nestan Tukvadze et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing ofMycobacterium tuberculosisin human macrophages

(2015) Rokeya Sultana Rekha et al.   Autophagy

NR1D1 amelioratesMycobacterium tuberculosisclearance through regulation of autophagy

(2015) Vemika Chandra et al.   Autophagy

Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe

(2015) Qingfei Zheng et al.   CHEMISTRY & BIOLOGY

Host-Directed Therapies for Tackling Multi-Drug Resistant Tuberculosis: Learning From the Pasteur-Bechamp Debates: Table 1.

(2015) Alimuddin Zumla et al.   CLINICAL INFECTIOUS DISEASES

Adjunctive vitamin D for treatment of active tuberculosis in India: a randomised, double-blind, placebo-controlled trial

(2015) Peter Daley et al.   LANCET INFECTIOUS DISEASES

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

(2015) Santosh Chauhan et al.   MOLECULAR CELL

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection

(2015) Jacqueline M. Kimmey et al.   NATURE

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial

(2015) Akhirunnesa Mily et al.   PLoS One

The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy

(2014) Chul-Su Yang et al.   Autophagy

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

(2014) M. Schiebler et al.   EMBO Molecular Medicine

Change in serum CXCL10 levels during anti-tuberculosis treatment depends on vitamin D status [Short Communication]

(2014) Z. Hasan et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy

(2014) Rituraj Pal et al.   Nature Communications

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth

(2014) Sarah A. Stanley et al.   PLoS Pathogens

Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis’

(2013) Nawal Salahuddin et al.   BMC INFECTIOUS DISEASES

A current perspective of autophagosome biogenesis

(2013) Shusaku T Shibutani et al.   CELL RESEARCH

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Noncanonical autophagy: one small step for LC3, one giant leap for immunity

(2013) Payal Mehta et al.   CURRENT OPINION IN IMMUNOLOGY

Autophagy and Cellular Immune Responses

(2013) Yuting Ma et al.   IMMUNITY

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

L-arginine and Vitamin D Adjunctive Therapies in Pulmonary Tuberculosis: A Randomised, Double-Blind, Placebo-Controlled Trial

(2013) Anna P. Ralph et al.   PLoS One

Oral intake of phenylbutyrate with or without vitamin D3upregulates the cathelicidin LL-37 in human macrophages: a dose finding study for treatment of tuberculosis

(2013) Akhirunnesa Mily et al.   BMC Pulmonary Medicine

Vitamin D Induces Interleukin-1β Expression: Paracrine Macrophage Epithelial Signaling Controls M. tuberculosis Infection

(2013) Mark Verway et al.   PLoS Pathogens

Vitamin D, tuberculin skin test conversion, and latent tuberculosis in Mongolian school-age children: a randomized, double-blind, placebo-controlled feasibility trial

(2012) Davaasambuu Ganmaa et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

ESX-1 dependent impairment of autophagic flux byMycobacterium tuberculosisin human dendritic cells

(2012) Alessandra Romagnoli et al.   Autophagy

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

(2012) Jwa-Jin Kim et al.   Cell Host & Microbe

Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

(2012) Jill Henault et al.   IMMUNITY

Dectin-1-triggered Recruitment of Light Chain 3 Protein to Phagosomes Facilitates Major Histocompatibility Complex Class II Presentation of Fungal-derived Antigens

(2012) Jun Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFN-  Elicits Macrophage Autophagy via the p38 MAPK Signaling Pathway

(2012) T. Matsuzawa et al.   JOURNAL OF IMMUNOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of autophagy in host defence against Mycobacterium tuberculosis infection

(2012) Mário Songane et al.   TUBERCULOSIS

Impact of Vitamin D in the Treatment of Tuberculosis

(2011) Khanh vinh quoc Luong et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial

(2011) Adrian R Martineau et al.   LANCET

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin D Is Required for IFN- -Mediated Antimicrobial Activity of Human Macrophages

(2011) M. Fabri et al.   Science Translational Medicine

Mediatory molecules that fuse autophagosomes and lysosomes

(2010) Nobumichi Furuta et al.   Autophagy

Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling

(2010) Dong-Min Shin et al.   CELLULAR MICROBIOLOGY

Role of autophagy in the host response to microbial infection and potential for therapy

(2010) Mario Fabri et al.   CURRENT OPINION IN IMMUNOLOGY

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation

(2010) Valérie Vingtdeux et al.   FASEB JOURNAL

Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties

(2010) Marisa Ponpuak et al.   IMMUNITY

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

(2010)   NATURE

T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism

(2010) K. Edfeldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterium tuberculosis Eis Regulates Autophagy, Inflammation, and Cell Death through Redox-dependent Signaling

(2010) Dong-Min Shin et al.   PLoS Pathogens

Structure and function of ESCRT-III: Table 1

(2009) Suman Lata et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

(2009) Jae-Min Yuk et al.   Cell Host & Microbe

The many niches and strategies used by pathogenic mycobacteria for survival within host macrophages

(2009) Chantal de Chastellier   IMMUNOBIOLOGY

Convergence of IL-1β and VDR Activation Pathways in Human TLR2/1-Induced Antimicrobial Responses

(2009) Philip T. Liu et al.   PLoS One

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE