MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity

RNA sequencing reveals widespread transcriptome changes in a renal carcinoma cell line

(2018) Agata Lichawska-Cieslar et al.   Oncotarget

Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity

(2017) Claudine Hahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MCPIP1 contributes to the inflammatory response of UVB-treated keratinocytes

(2017) Beata Bugara et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The monounsaturated fatty acid oleate is the major physiological toxic free fatty acid for human beta cells

(2017) T Plötz et al.   Nutrition & Diabetes

MCPIP1, alias Regnase-1 binds and cleaves mRNA of C/EBPβ

(2017) Barbara Lipert et al.   PLoS One

Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines

(2016) Ewa Gurgul-Convey et al.   DIABETOLOGIA

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production

(2016) Ewelina Dobosz et al.   Journal of Innate Immunity

Physiological characterization of the human EndoC-βH1 β-cell line

(2015) Ewa Gurgul-Convey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TNF-α Antibody Therapy in Combination With the T-Cell–Specific Antibody Anti-TCR Reverses the Diabetic Metabolic State in the LEW.1AR1-iddmRat

(2015) Anne Jörns et al.   DIABETES

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

(2015) Flora Brozzi et al.   DIABETOLOGIA

MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research

(2015) Jonàs Juan-Mateu et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

MCPIP: a key player in macrophage polarization

(2015) Pappachan Kolattukudy   Oncotarget

Islet inflammation in human type 1 diabetes mellitus

(2014) Noel G. Morgan et al.   IUBMB LIFE

Nova1 is a master regulator of alternative splicing in pancreatic beta cells

(2014) Olatz Villate et al.   NUCLEIC ACIDS RESEARCH

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation andβ-cell apoptosis

(2013) I. Santin et al.   DIABETES OBESITY & METABOLISM

Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes

(2013) Anne Jörns et al.   DIABETOLOGIA

USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO

(2013) Jixiao Niu et al.   EMBO JOURNAL

Targeted disruption of MCPIP1/Zc3h12a results in fatal inflammatory disease

(2013) Ruidong Miao et al.   IMMUNOLOGY AND CELL BIOLOGY

Effects of the novel mitochondrial protein mimitin in insulin-secreting cells

(2012) Katarzyna Hanzelka et al.   BIOCHEMICAL JOURNAL

Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) is a novel multifunctional modulator of inflammatory reactions

(2012) Jolanta Jura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells

(2012) F Allagnat et al.   CELL DEATH AND DIFFERENTIATION

On the Immense Variety and Complexity of Circumstances Conditioning Pancreatic  -Cell Apoptosis in Type 1 Diabetes

(2012) D. L. Eizirik et al.   DIABETES

Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2012) D. L. Eizirik et al.   DIABETOLOGIA

Mechanism of Prostacyclin-Induced Potentiation of Glucose-Induced Insulin Secretion

(2012) Ewa Gurgul-Convey et al.   ENDOCRINOLOGY

MCPIP1 Down-Regulates IL-2 Expression through an ARE-Independent Pathway

(2012) Min Li et al.   PLoS One

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Differential effects of proinflammatory cytokines on cell death and ER stress in insulin-secreting INS1E cells and the involvement of nitric oxide

(2011) Stella Kacheva et al.   CYTOKINE

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

MCP-1-induced protein attenuates endotoxin-induced myocardial dysfunction by suppressing cardiac NF-кB activation via inhibition of IкB kinase activation

(2011) Jianli Niu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria

(2011) Ewa Gurgul-Convey et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis

(2010) F Allagnat et al.   CELL DEATH AND DIFFERENTIATION

Protection against Cytokine Toxicity through Endoplasmic Reticulum and Mitochondrial Stress Prevention by Prostacyclin Synthase Overexpression in Insulin-producing Cells

(2010) Ewa Gurgul-Convey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-κB signaling

(2010) Jian Liang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory feedback loop between NF-κB and MCP-1-induced protein 1 RNase

(2009) Lukasz Skalniak et al.   FEBS Journal

Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1β mRNA

(2009) Danuta Mizgalska et al.   FEBS Journal

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

(2009) Kazufumi Matsushita et al.   NATURE

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS

Identification of interleukin-1 and interleukin-6-responsive genes in human monocyte-derived macrophages using microarrays

(2008) Jolanta Jura et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells

(2008) F. Ortis et al.   DIABETOLOGIA