Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease

Fibrillar Amyloid-β1-42 Modifies Actin Organization Affecting the Cofilin Phosphorylation State: A Role for Rac1/cdc42 Effector Proteins and the Slingshot Phosphatase

(2018) Ariadna Mendoza-Naranjo et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma Gelsolin is Decreased and Correlates with Rate of Decline in Alzheimer's Disease

(2017) Andreas Güntert et al.   JOURNAL OF ALZHEIMERS DISEASE

Profilin Regulates F-Actin Network Homeostasis by Favoring Formin over Arp2/3 Complex

(2015) Cristian Suarez et al.   DEVELOPMENTAL CELL

The internal architecture of dendritic spines revealed by super-resolution imaging: What did we learn so far?

(2015) Harold D. MacGillavry et al.   EXPERIMENTAL CELL RESEARCH

Myosin IIb-dependent Regulation of Actin Dynamics Is Required forN-Methyl-d-aspartate Receptor Trafficking during Synaptic Plasticity

(2015) Yunfei Bu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus

(2015) Gangsoo Jung et al.   JOURNAL OF NEUROCHEMISTRY

Two-Photon Correlation Spectroscopy in Single Dendritic Spines Reveals Fast Actin Filament Reorganization during Activity-Dependent Growth

(2015) Jian-Hua Chen et al.   PLoS One

Nicotinic ACh receptors as therapeutic targets in CNS disorders

(2015) Kelly T. Dineley et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture

(2015) Marta Esteves da Silva et al.   Cell Reports

Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis

(2014) Michela Guglielmotto et al.   Autophagy

Activity-Dependent Structural Plasticity of Perisynaptic Astrocytic Domains Promotes Excitatory Synapse Stability

(2014) Yann Bernardinelli et al.   CURRENT BIOLOGY

Drebrin inhibits cofilin-induced severing of F-actin

(2014) Elena E. Grintsevich et al.   Cytoskeleton

Calcium influx and postsynaptic proteins coordinate the dendritic filopodium-spine transition

(2014) Hsiao-Tang Hu et al.   Developmental Neurobiology

Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion

(2014) Anaël Chazeau et al.   EMBO JOURNAL

The A 1-42 peptide regulates microtubule stability independently of tau

(2014) B. Pianu et al.   JOURNAL OF CELL SCIENCE

Dendritic spine heterogeneity and calcium dynamics in basolateral amygdala principal neurons

(2014) John M. Power et al.   JOURNAL OF NEUROPHYSIOLOGY

Multiple Spatial and Kinetic Subpopulations of CaMKII in Spines and Dendrites as Resolved by Single-Molecule Tracking PALM

(2014) H. E. Lu et al.   JOURNAL OF NEUROSCIENCE

Valproic Acid Alleviates Memory Deficits and Attenuates Amyloid-β Deposition in Transgenic Mouse Model of Alzheimer’s Disease

(2014) Ai-Guo Xuan et al.   MOLECULAR NEUROBIOLOGY

Spine neck plasticity regulates compartmentalization of synapses

(2014) Jan Tønnesen et al.   NATURE NEUROSCIENCE

Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

(2014) Meredith A. Chabrier et al.   NEUROBIOLOGY OF DISEASE

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

Balance and Stability of Synaptic Structures during Synaptic Plasticity

(2014) Daniel Meyer et al.   NEURON

The actin cytoskeleton in memory formation

(2014) Raphael Lamprecht   PROGRESS IN NEUROBIOLOGY

ER to synapse trafficking of NMDA receptors

(2014) Martin Horak et al.   Frontiers in Cellular Neuroscience

A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells

(2013) J. R. Stehn et al.   CANCER RESEARCH

Therapeutic Effects of Quetiapine on Memory Deficit and Brain β-Amyloid Plaque Pathology in a Transgenic Mouse Model of Alzheimer’s Disease

(2013) Shenghua Zhu et al.   Current Alzheimer Research

Gelsolin: The tail of a molecular gymnast

(2013) Shalini Nag et al.   Cytoskeleton

Functions of Class V Myosins in Neurons

(2013) John A. Hammer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drebrin-induced Stabilization of Actin Filaments

(2013) Mouna A. Mikati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-  signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease

(2013) M. E. Seward et al.   JOURNAL OF CELL SCIENCE

Dendritic Spine Density, Morphology, and Fibrillar Actin Content Surrounding Amyloid-β Plaques in a Mouse Model of Amyloid-β Deposition

(2013) Caitlin M. Kirkwood et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Synaptic Regulation of Microtubule Dynamics in Dendritic Spines by Calcium, F-Actin, and Drebrin

(2013) E. B. Merriam et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Cofilin Regulates Extinction of Conditioned Aversive Memory via AMPAR Trafficking

(2013) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Spine Morphogenesis: A Role for the Actin-Capping Protein Eps8

(2013) E. Stamatakou et al.   JOURNAL OF NEUROSCIENCE

Cerebral atrophy in mild cognitive impairment and Alzheimer disease: Rates and acceleration

(2013) K. K. Leung et al.   NEUROLOGY

The Small GTPase Arf1 Modulates Arp2/3-Mediated Actin Polymerization via PICK1 to Regulate Synaptic Plasticity

(2013) Daniel L. Rocca et al.   NEURON

AMPARs and Synaptic Plasticity: The Last 25 Years

(2013) Richard L. Huganir et al.   NEURON

Evaluating Alzheimer’s Disease Progression Using Rate of Regional Hippocampal Atrophy

(2013) Edit Frankó et al.   PLoS One

Surface trafficking of NMDA receptors: Gathering from a partner to another

(2013) Laurent Ladépêche et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines

(2012) Peter Penzes et al.   Cytoskeleton

Dendritic spines: from structure to in vivo function

(2012) Nathalie L Rochefort et al.   EMBO REPORTS

Activity-dependent actin dynamics are required for the maintenance of long-term plasticity and for synaptic capture

(2012) Rosalina Fonseca   EUROPEAN JOURNAL OF NEUROSCIENCE

Regulation of dendritic branching by Cdc42 GAPs

(2012) S. Simo et al.   GENES & DEVELOPMENT

Arp2/3 complex–dependent actin networks constrain myosin II function in driving retrograde actin flow

(2012) Qing Yang et al.   JOURNAL OF CELL BIOLOGY

The myosin superfamily at a glance

(2012) M. A. Hartman et al.   JOURNAL OF CELL SCIENCE

Rab8 Modulates Metabotropic Glutamate Receptor Subtype 1 Intracellular Trafficking and Signaling in a Protein Kinase C-Dependent Manner

(2012) J. L. Esseltine et al.   JOURNAL OF NEUROSCIENCE

New insights into the regulation and cellular functions of the ARP2/3 complex

(2012) Jeremy D. Rotty et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

Cofilin under control of  -arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning

(2012) C. G. Pontrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Tropomyosin Position on F-Actin Revealed by EM Reconstruction and Computational Chemistry

(2011) Xiaochuan (Edward) Li et al.   BIOPHYSICAL JOURNAL

Structural plasticity of dendritic spines

(2011) Miquel Bosch et al.   CURRENT OPINION IN NEUROBIOLOGY

Cofilin Aggregation Blocks Intracellular Trafficking and Induces Synaptic Loss in Hippocampal Neurons

(2011) Joseph Cichon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin Capping Protein Is Required for Dendritic Spine Development and Synapse Formation

(2011) Y. Fan et al.   JOURNAL OF NEUROSCIENCE

Tau Protein Is Required for Amyloid  -Induced Impairment of Hippocampal Long-Term Potentiation

(2011) O. A. Shipton et al.   JOURNAL OF NEUROSCIENCE

Evaluation of a Calibrated 18F-FDG PET Score as a Biomarker for Progression in Alzheimer Disease and Mild Cognitive Impairment

(2011) K. Herholz et al.   JOURNAL OF NUCLEAR MEDICINE

In vivotwo-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice

(2011) Jun Noguchi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Remodeling of actin filaments by ADF/cofilin proteins

(2011) V. E. Galkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Postsynaptic Organization of Synapses

(2011) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model

(2010) David E. Hurtado et al.   AMERICAN JOURNAL OF PATHOLOGY

Morphology and dynamics of perisynaptic glia

(2010) Andreas Reichenbach et al.   BRAIN RESEARCH REVIEWS

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

ADF/Cofilin-Actin Rods in Neurodegenerative Diseases

(2010) J.R. Bamburg et al.   Current Alzheimer Research

WASH and the Arp2/3 complex regulate endosome shape and trafficking

(2010) Steve N. Duleh et al.   Cytoskeleton

New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2

(2010) Thomas Fath et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Vasodilator-stimulated Phosphoprotein (VASP) Induces Actin Assembly in Dendritic Spines to Promote Their Development and Potentiate Synaptic Strength

(2010) Wan-Hsin Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VASP is a processive actin polymerase that requires monomeric actin for barbed end association

(2010) Scott D. Hansen et al.   JOURNAL OF CELL BIOLOGY

Actin in dendritic spines: connecting dynamics to function

(2010) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

Calcium Binding to PICK1 Is Essential for the Intracellular Retention of AMPA Receptors Underlying Long-Term Depression

(2010) A. Citri et al.   JOURNAL OF NEUROSCIENCE

Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neurons

(2010) Eunice Y. Yuen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Which way to go? Cytoskeletal organization and polarized transport in neurons

(2010) Lukas C. Kapitein et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Atomic Force Microscopy Reveals Drebrin Induced Remodeling of F-Actin with Subnanometer Resolution

(2010) Shivani Sharma et al.   NANO LETTERS

Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons

(2010) Wolfgang Wagner et al.   NATURE CELL BIOLOGY

ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity

(2010) Jiaping Gu et al.   NATURE NEUROSCIENCE

Cognition, glucose metabolism and amyloid burden in Alzheimer's disease

(2010) Ansgar J. Furst et al.   NEUROBIOLOGY OF AGING

Single-Molecule Discrimination of Discrete Perisynaptic and Distributed Sites of Actin Filament Assembly within Dendritic Spines

(2010) Nicholas A. Frost et al.   NEURON

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

ADF/Cofilin: a functional node in cell biology

(2010) Barbara W. Bernstein et al.   TRENDS IN CELL BIOLOGY

Molecular Basis for the Dual Function of Eps8 on Actin Dynamics: Bundling and Capping

(2010) Maud Hertzog et al.   PLOS BIOLOGY

Oxidative stress damage and oxidative stress responses in the choroid plexus in Alzheimer’s disease

(2009) Ester Perez-Gracia et al.   ACTA NEUROPATHOLOGICA

Synaptic degeneration in Alzheimer’s disease

(2009) Thomas Arendt   ACTA NEUROPATHOLOGICA

Dendritic spine formation and stabilization

(2009) Yoshihiro Yoshihara et al.   CURRENT OPINION IN NEUROBIOLOGY

Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls

(2009) Jonathan H. Morra et al.   HUMAN BRAIN MAPPING

Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis

(2009) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

Drebrin A regulates dendritic spine plasticity and synaptic function in mature cultured hippocampal neurons

(2009) A. Ivanov et al.   JOURNAL OF CELL SCIENCE

The Shape and Flexibility of Tropomyosin Coiled Coils: Implications for Actin Filament Assembly and Regulation

(2009) Xiaochuan (Edward) Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Interfering with the Actin Network and Its Effect on Long-Term Potentiation and Synaptic Tagging in Hippocampal CA1 Neurons in Slices In Vitro

(2009) B. Ramachandran et al.   JOURNAL OF NEUROSCIENCE

 -Amyloid Monomers Are Neuroprotective

(2009) M. L. Giuffrida et al.   JOURNAL OF NEUROSCIENCE

Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis

(2009) Farida Korobova et al.   MOLECULAR BIOLOGY OF THE CELL

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach

(2009) Wei Lu et al.   NEURON

Myosin Vb Mobilizes Recycling Endosomes and AMPA Receptors for Postsynaptic Plasticity

(2008) Zhiping Wang et al.   CELL

Ena/VASP Proteins Capture Actin Filament Barbed Ends

(2008) Lejla Pasic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of actin filament branching by the Arp2/3 complex

(2008) Isabelle Rouiller et al.   JOURNAL OF CELL BIOLOGY

Formin Proteins of the DAAM Subfamily Play a Role during Axon Growth

(2008) T. Matusek et al.   JOURNAL OF NEUROSCIENCE

Organization of the Arp2/3 Complex in Hippocampal Spines

(2008) B. Racz et al.   JOURNAL OF NEUROSCIENCE

Arp2/3 Complex Is Important for Filopodia Formation, Growth Cone Motility, and Neuritogenesis in Neuronal Cells

(2008) Farida Korobova et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis

(2008) Daniel L. Rocca et al.   NATURE CELL BIOLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Motor protein–dependent transport of AMPA receptors into spines during long-term potentiation

(2008) Susana S Correia et al.   NATURE NEUROSCIENCE

The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines

(2008) Naoki Honkura et al.   NEURON

A nomenclature for ligand-gated ion channels

(2008) Graham L. Collingridge et al.   NEUROPHARMACOLOGY

Delivery of AMPA receptors to perisynaptic sites precedes the full expression of long-term potentiation

(2008) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live-cell imaging of dendritic spines by STED microscopy

(2008) U. V. Nagerl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA