Molecular Mechanoneurobiology: An Emerging Angle to Explore Neural Synaptic Functions

Mechanical Tension Drives Cell Membrane Fusion

(2015) Ji Hoon Kim et al.   DEVELOPMENTAL CELL

Compressive Stress Induces Dephosphorylation of the Myosin Regulatory Light Chain via RhoA Phosphorylation by the Adenylyl Cyclase/Protein Kinase A Signaling Pathway

(2015) Kenji Takemoto et al.   PLoS One

Force-dependent vinculin binding to talin in live cells: a crucial step in anchoring the actin cytoskeleton to focal adhesions

(2014) Hiroaki Hirata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cadherin Adhesion and Mechanotransduction

(2014) D.E. Leckband et al.   Annual Review of Cell and Developmental Biology

Functional coupling of ion channels in cellular mechanotransduction

(2014) Vladislav I. Chubinskiy-Nadezhdin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Serine/Threonine Kinase Ndr2 Controls Integrin Trafficking and Integrin-Dependent Neurite Growth

(2014) K. Rehberg et al.   JOURNAL OF NEUROSCIENCE

Mechanical coupling maintains the fidelity of NMDA receptor–mediated currents

(2014) Rashek Kazi et al.   NATURE NEUROSCIENCE

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The minimal cadherin-catenin complex binds to actin filaments under force

(2014) C. D. Buckley et al.   SCIENCE

Resolving the molecular mechanism of cadherin catch bond formation

(2014) Kristine Manibog et al.   Nature Communications

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Intercellular protein–protein interactions at synapses

(2014) Xiaofei Yang et al.   Protein & Cell

The ion channels to cytoskeleton connection as potential mechanism of mechanosensitivity

(2013) Boris Martinac   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The mechanical control of nervous system development

(2013) K. Franze   DEVELOPMENT

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics

(2013) Matthias Kneussel et al.   NATURE REVIEWS NEUROSCIENCE

Cell adhesion and homeostatic synaptic plasticity

(2013) Agnes Thalhammer et al.   NEUROPHARMACOLOGY

Dynamic control of  1 integrin adhesion by the plexinD1-sema3E axis

(2013) Y. I. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds

(2013) C.-y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tension modulates actin filament polymerization mediated by formin and profilin

(2013) N. Courtemanche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formin mDia1 senses and generates mechanical forces on actin filaments

(2013) Antoine Jégou et al.   Nature Communications

Strength in the Periphery: Growth Cone Biomechanics and Substrate Rigidity Response in Peripheral and Central Nervous System Neurons

(2012) Daniel Koch et al.   BIOPHYSICAL JOURNAL

Notch Ligand Endocytosis Generates Mechanical Pulling Force Dependent on Dynamin, Epsins, and Actin

(2012) Laurence Meloty-Kapella et al.   DEVELOPMENTAL CELL

Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells

(2012) Wei Chen et al.   JOURNAL OF CELL BIOLOGY

Interactions between ICAM-5 and β1 integrins regulate neuronal synapse formation

(2012) Lin Ning et al.   JOURNAL OF CELL SCIENCE

Molecular force transduction by ion channels – diversity and unifying principles

(2012) Sergei Sukharev et al.   JOURNAL OF CELL SCIENCE

Integrin  1 Signals through Arg to Regulate Postnatal Dendritic Arborization, Synapse Density, and Behavior

(2012) M. S. Warren et al.   JOURNAL OF NEUROSCIENCE

The mechanobiology of brain function

(2012) William J. Tyler   NATURE REVIEWS NEUROSCIENCE

Coupling Mechanical Forces to Electrical Signaling

(2012) Joshua Barry et al.   NEUROSCIENTIST

 3 integrin interacts directly with GluA2 AMPA receptor subunit and regulates AMPA receptor expression in hippocampal neurons

(2012) K. Pozo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ideal, catch, and slip bonds in cadherin adhesion

(2012) S. Rakshit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial Mechanosensitive Channels as a Paradigm for Mechanosensory Transduction

(2011) Boris Martinac   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

A Hitchhiker's Guide to Mechanobiology

(2011) Jeroen Eyckmans et al.   DEVELOPMENTAL CELL

Biophysics of substrate interaction: Influence on neural motility, differentiation, and repair

(2011) Simon W. Moore et al.   Developmental Neurobiology

Regulation of axonal outgrowth and pathfinding by integrin-ecm interactions

(2011) Jonathan P. Myers et al.   Developmental Neurobiology

N-Methyl-d-aspartate Receptor Mechanosensitivity Is Governed by C Terminus of NR2B Subunit

(2011) Pallab Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strain-dependent Up-regulation of Ephrin-B2 Protein in Periodontal Ligament Fibroblasts Contributes to Osteogenesis during Tooth Movement

(2011) Katja Diercke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors

(2011) Peter W. Janes et al.   JOURNAL OF CELL BIOLOGY

Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament

(2011) Kimihide Hayakawa et al.   JOURNAL OF CELL BIOLOGY

Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography

(2011) Matthew C. Murphy et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Synaptic transmission and plasticity are modulated by nonmuscle myosin II at the neuromuscular junction of Drosophila

(2011) Sara Seabrooke et al.   JOURNAL OF NEUROPHYSIOLOGY

EphB Controls NMDA Receptor Function and Synaptic Targeting in a Subunit-Specific Manner

(2011) M. J. Nolt et al.   JOURNAL OF NEUROSCIENCE

Walking to work: roles for class V myosins as cargo transporters

(2011) John A. Hammer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Myosin IIB Activity and Phosphorylation Status Determines Dendritic Spine and Post-Synaptic Density Morphology

(2011) Jennifer L. Hodges et al.   PLoS One

The emerging role of forces in axonal elongation

(2011) Daniel M. Suter et al.   PROGRESS IN NEUROBIOLOGY

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

The effects of hyaluronic acid hydrogels with tunable mechanical properties on neural progenitor cell differentiation

(2010) Stephanie K. Seidlits et al.   BIOMATERIALS

Strength Dependence of Cadherin-Mediated Adhesions

(2010) Benoit Ladoux et al.   BIOPHYSICAL JOURNAL

Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing

(2010) Simon W. Moore et al.   DEVELOPMENTAL CELL

Integrin Signaling Switches the Cytoskeletal and Exocytic Machinery that Drives Neuritogenesis

(2010) Stephanie L. Gupton et al.   DEVELOPMENTAL CELL

The function of mechanical tension in neuronal and network development

(2010) Amir Ayali   Integrative Biology

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins

(2010) Benjamin D. Matthews et al.   Integrative Biology

Nanomechanics of the Cadherin Ectodomain

(2010) Javier Oroz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-cadherin: stabilizing synapses: Figure 1.

(2010) Jyothi Arikkath   JOURNAL OF CELL BIOLOGY

N-cadherin mediates plasticity-induced long-term spine stabilization

(2010) Pablo Mendez et al.   JOURNAL OF CELL BIOLOGY

Mechanosensitivity of astrocytes on optimized polyacrylamide gels analyzed by quantitative morphometry

(2010) Pouria Moshayedi et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel

(2010) Arthur Beyder et al.   JOURNAL OF PHYSIOLOGY-LONDON

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Mechanosensitive gating of CFTR

(2010) Wei Kevin Zhang et al.   NATURE CELL BIOLOGY

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Two-step adhesive binding by classical cadherins

(2010) Oliver J Harrison et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Myosin IIb Regulates Actin Dynamics during Synaptic Plasticity and Memory Formation

(2010) Christopher S. Rex et al.   NEURON

Stretch-Activated Ion Channels: What Are They?

(2010) Frederick Sachs   PHYSIOLOGY

Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development

(2010) Yukio Akaneya et al.   PLoS One

N-cadherin-dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth

(2010) Z.-J. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell mechanics provides a sensitive and quantitative means for probing amyloid-  peptide and neuronal cell interactions

(2010) V. Lulevich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The biophysics of neuronal growth

(2010) Kristian Franze et al.   REPORTS ON PROGRESS IN PHYSICS

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

The Regulative Role of Neurite Mechanical Tension in Network Development

(2009) Sarit Anava et al.   BIOPHYSICAL JOURNAL

Neurite Branch Retraction Is Caused by a Threshold-Dependent Mechanical Impact

(2009) Kristian Franze et al.   BIOPHYSICAL JOURNAL

Mechanical Distortion of Single Actin Filaments Induced by External Force: Detection by Fluorescence Imaging

(2009) Togo Shimozawa et al.   BIOPHYSICAL JOURNAL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

The mechanical integrin cycle

(2009) E. Puklin-Faucher et al.   JOURNAL OF CELL SCIENCE

Focal Adhesion Kinase Acts Downstream of EphB Receptors to Maintain Mature Dendritic Spines by Regulating Cofilin Activity

(2009) Y. Shi et al.   JOURNAL OF NEUROSCIENCE

A Presynaptic Homeostatic Signaling System Composed of the Eph Receptor, Ephexin, Cdc42, and CaV2.1 Calcium Channels

(2009) C. Andrew Frank et al.   NEURON

The emerging role of integrins in neuropsychiatric disorders

(2009) Ana M D Carneiro   NEUROPSYCHOPHARMACOLOGY

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

A Physical Model of Axonal Elongation: Force, Viscosity, and Adhesions Govern the Mode of Outgrowth

(2008) Matthew O’Toole et al.   BIOPHYSICAL JOURNAL

Substrate Modulus Directs Neural Stem Cell Behavior

(2008) Krishanu Saha et al.   BIOPHYSICAL JOURNAL

Integrin activation modulates NMDA and AMPA receptor function of CA1 cells in a dose-related fashion in vivo

(2008) Gábor Juhász et al.   BRAIN RESEARCH

Eph/ephrin signaling: networks

(2008) D. Arvanitis et al.   GENES & DEVELOPMENT

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

(2008) Margaret L. Gardel et al.   JOURNAL OF CELL BIOLOGY

Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus

(2008) Marie-Ève Tremblay et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain

(2008) David Bouvier et al.   JOURNAL OF NEUROCHEMISTRY

A Molecular Clutch between the Actin Flow and N-Cadherin Adhesions Drives Growth Cone Migration

(2008) L. Bard et al.   JOURNAL OF NEUROSCIENCE

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

EphB Receptors Couple Dendritic Filopodia Motility to Synapse Formation

(2008) Matthew S. Kayser et al.   NEURON

Meltrin β/ADAM19 Interacting with EphA4 in Developing Neural Cells Participates in Formation of the Neuromuscular Junction

(2008) Norihiro Yumoto et al.   PLoS One

Eph, a Protein Family Coming of Age: More Confusion, Insight, or Complexity?

(2008) M. Lackmann et al.   Science Signaling

Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity

(2008) Jyothi Arikkath et al.   TRENDS IN NEUROSCIENCES