Statin Treatment in Multiple Sclerosis: A Systematic Review and Meta-Analysis

Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes

(2014) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

(2014) Jeremy Chataway et al.   LANCET

Atorvastatin Added to Interferon Beta for Relapsing Multiple Sclerosis: 12-Month Treatment Extension of the Randomized Multicenter SWABIMS Trial

(2014) Christian P. Kamm et al.   PLoS One

Modulation of Rho-Rock signaling pathway protects oligodendrocytes against cytokine toxicity via PPAR-α-dependent mechanism

(2013) Ajaib S. Paintlia et al.   GLIA

Should people at low risk of cardiovascular disease take a statin?

(2013) J. D. Abramson et al.   BMJ-British Medical Journal

Inhibition of Interferon-beta Responses in Multiple Sclerosis Immune Cells Associated With High-Dose Statins

(2012) Xuan Feng et al.   ARCHIVES OF NEUROLOGY

Atorvastatin added to interferon beta for relapsing multiple sclerosis: a randomized controlled trial

(2012) Christian Philipp Kamm et al.   JOURNAL OF NEUROLOGY

Randomized controlled trial of atorvastatin in clinically isolated syndrome: The STAyCIS study

(2012) E. Waubant et al.   NEUROLOGY

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

(2011) Chris H. Polman et al.   ANNALS OF NEUROLOGY

Simvastatin as add-on therapy to interferon beta-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial

(2011) Per Soelberg Sorensen et al.   LANCET NEUROLOGY

Statin therapy and multiple sclerosis disability in a population-based cohort

(2011) M Mateo Paz Soldán et al.   Multiple Sclerosis Journal

Simvastatin improves final visual outcome in acute optic neuritis: a randomized study

(2011) Anna Tsakiri et al.   Multiple Sclerosis Journal

Simvastatin treatment in patients with relapsing-remitting multiple sclerosis receiving interferon beta 1a: a double-blind randomized controlled trial

(2010) Mansoureh Togha et al.   Multiple Sclerosis Journal

Atorvastatin Combined To Interferon to Verify the Efficacy (ACTIVE) in relapsing— remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapy

(2010) Roberta Lanzillo et al.   Multiple Sclerosis Journal

Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis

(2010) R. A. Marrie et al.   NEUROLOGY

Effect of statins on clinical and molecular responses to intramuscular interferon beta-1a

(2009) R. A. Rudick et al.   NEUROLOGY

Statins: Mechanisms of neuroprotection

(2009) Peter J. van der Most et al.   PROGRESS IN NEUROBIOLOGY

The IFN-γ-induced transcriptional program of the CIITA gene is inhibited by statins

(2008) Sun J. Lee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Simvastatin-Mediated Upregulation of VEGF and BDNF, Activation of the PI3K/Akt Pathway, and Increase of Neurogenesis Are Associated with Therapeutic Improvement after Traumatic Brain Injury

(2008) Hongtao Wu et al.   JOURNAL OF NEUROTRAUMA

Atorvastatin decreases high-sensitivity C-reactive protein in multiple sclerosis

(2008) J Sellner et al.   Multiple Sclerosis Journal

Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis

(2008) G. Birnbaum et al.   NEUROLOGY

Oral High-Dose Atorvastatin Treatment in Relapsing-Remitting Multiple Sclerosis

(2008) Friedemann Paul et al.   PLoS One

Geranylgeranylation but Not GTP-Loading of Rho GTPases Determines T Cell Function

(2008) S. Waiczies et al.   Science Signaling

Simvastatin Reduces the Association of NMDA Receptors to Lipid Rafts

(2008) Jovita Ponce et al.   STROKE