A neuroprotective role for microglia in prion diseases

Prion Infections and Anti-PrP Antibodies Trigger Converging Neurotoxic Pathways

(2015) Uli S. Herrmann et al.   PLoS Pathogens

Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease

(2014) Diego Gómez-Nicola et al.   GLIA

Live imaging of prions reveals nascent PrPScin cell-surface, raft-associated amyloid strings and webs

(2014) Alexander Rouvinski et al.   JOURNAL OF CELL BIOLOGY

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

(2013) Tiziana Sonati et al.   NATURE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Follicular dendritic cells: origin, phenotype, and function in health and disease

(2013) Adriano Aguzzi et al.   TRENDS IN IMMUNOLOGY

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

(2012) Noël C. Derecki et al.   NATURE

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Prion propagation, toxicity and degradation

(2012) Adriano Aguzzi et al.   NATURE NEUROSCIENCE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

ZyFISH: A Simple, Rapid and Reliable Zygosity Assay for Transgenic Mice

(2012) Donal McHugh et al.   PLoS One

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Prion Pathogenesis Is Faithfully Reproduced in Cerebellar Organotypic Slice Cultures

(2012) Jeppe Falsig et al.   PLoS Pathogens

Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

(2011) A. Mildner et al.   JOURNAL OF NEUROSCIENCE

CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity

(2011) J. T. Rogers et al.   JOURNAL OF NEUROSCIENCE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

(2010) Shau-Kwaun Chen et al.   CELL

Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation

(2010) Martina M. Hughes et al.   GLIA

Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain–dependent manner

(2010) Jan Kranich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

The prion organotypic slice culture assay—POSCA

(2008) Jeppe Falsig et al.   Nature Protocols