SHOC2–MRAS–PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors

(2017) Marta Carrara et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors

(2017) Marta Carrara et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease

(2016) Lijiang Ma et al.   HUMAN GENETICS

SHOC2 subcellular shuttling requires the KEKE motif-rich region andN-terminal leucine-rich repeat domain and impacts on ERK signalling

(2016) Marialetizia Motta et al.   HUMAN MOLECULAR GENETICS

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

(2016) Ying-Nan P. Chen et al.   NATURE

Metals in the active site of native protein phosphatase-1

(2015) Ewald Heroes et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors

(2015) S. R. Whittaker et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of RAF protein kinases in ERK signalling

(2015) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A NovelSHOC2Variant in Rasopathy

(2014) Vickie Hannig et al.   HUMAN MUTATION

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction

(2014) Aidan G Gilmartin et al.   Nature Chemical Biology

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

(2014) Navasona Krishnan et al.   Nature Chemical Biology

De Novo Mutations in Moderate or Severe Intellectual Disability

(2014) Fadi F. Hamdan et al.   PLoS Genetics

The RASopathies

(2013) Katherine A. Rauen   Annual Review of Genomics and Human Genetics

An MRAS, SHOC2, and SCRIB Complex Coordinates ERK Pathway Activation with Polarity and Tumorigenic Growth

(2013) Lucy C. Young et al.   MOLECULAR CELL

Functional Integration of the Conserved Domains of Shoc2 Scaffold

(2013) Myoungkun Jeoung et al.   PLoS One

Structural Biology of Arf and Rab GTPases’ Effector Recruitment and Specificity

(2013) Amir R. Khan et al.   STRUCTURE

Challenges and Opportunities in the Development of Protein Phosphatase-Directed Therapeutics

(2012) Sofie De Munter et al.   ACS Chemical Biology

Structural basis for protein phosphatase 1 regulation and specificity

(2012) Wolfgang Peti et al.   FEBS Journal

Costello syndrome: a Ras/mitogen activated protein kinase pathway syndrome (rasopathy) resulting from HRAS germline mutations

(2012) Karen W. Gripp et al.   GENETICS IN MEDICINE

SHOC2 and CRAF Mediate ERK1/2 Reactivation in Mutant NRAS-mediated Resistance to RAF Inhibitor

(2012) Fred M. Kaplan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intrinsically disordered proteins: a 10-year recap

(2012) Peter Tompa   TRENDS IN BIOCHEMICAL SCIENCES

Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling

(2010) M. Molzan et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1)

(2010) A. Mishra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The extended PP1 toolkit: designed to create specificity

(2010) Mathieu Bollen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Basis for the Isoform-specific Interaction of Myosin Phosphatase Subunits Protein Phosphatase 1c β and Myosin Phosphatase Targeting Subunit 1

(2009) Elizabeth Scotto-Lavino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair

(2009) Viviana Cordeddu et al.   NATURE GENETICS

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One