In vitro experimental models for examining the skeletal muscle cell biology of exercise: the possibilities, challenges and future developments

Electrical pulse stimulation induces GLUT4 translocation in C2C12 myotubes that depends on Rab8A, Rab13, and Rab14

(2018) Zhu Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMP-activated protein kinase stabilizes FOXO3 in primary myotubes

(2018) Anthony M.J. Sanchez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PKC and Rab13 mediate Ca 2+ signal-regulated GLUT4 traffic

(2018) Bangli Deng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK in skeletal muscle function and metabolism

(2018) Rasmus Kjøbsted et al.   FASEB JOURNAL

Electrical pulse stimulation induces GLUT4 translocation in a Rac-Akt-dependent manner in C2C12 myotubes

(2018) Fang Hu et al.   FEBS LETTERS

Probing the Effect of Physiological Concentrations of IL-6 on Insulin Secretion by INS-1 832/3 Insulinoma Cells under Diabetic-Like Conditions

(2018) Jonathan Barlow et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Conditioned medium from contracting skeletal muscle cells reverses insulin resistance and dysfunction of endothelial cells

(2018) Yihe Zhao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of extracellular orotic acid on acute contraction-induced adaptation patterns in C2C12 cells

(2018) Thomas Beiter et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Skeletal Muscle PGC1α −1 Nucleosome Position and −260 nt DNA Methylation Determine Exercise Response and Prevent Ectopic Lipid Accumulation in Men

(2017) Sudip Bajpeyi et al.   ENDOCRINOLOGY

Electrical pulse stimulation: an in vitro exercise model for the induction of human skeletal muscle cell hypertrophy. A proof-of-concept study

(2017) Janelle Tarum et al.   EXPERIMENTAL PHYSIOLOGY

Leucine supplementation after mechanical stimulation activates protein synthesis via L-type amino acid transporter 1 in vitro

(2017) Naoya Nakai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Metabolic effects of physiological levels of caffeine in myotubes

(2017) Jamie K. Schnuck et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines

(2017) S. Pourteymour et al.   Molecular Metabolism

Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK

(2017) Sung-Jun Park et al.   EBioMedicine

Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism

(2017) Jenny Lund et al.   PLoS One

Electrical pulse stimulation of cultured skeletal muscle cells as a model for in vitro exercise - possibilities and limitations

(2016) N. Nikolić et al.   Acta Physiologica

Contracting C2C12 myotubes release CCL2 in an NF-κB-dependent manner to induce monocyte chemoattraction

(2016) Shouta Miyatake et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

APPL1 promotes glucose uptake in response to mechanical stretch via the PKCζ-non-muscle myosin IIa pathway in C2C12 myotubes

(2016) Tsugumichi Saito et al.   CELLULAR SIGNALLING

Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release

(2016) Lee D. Roberts et al.   DIABETES

Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association

(2016) Sheri R. Colberg et al.   DIABETES CARE

AMP-activated protein kinase-mediated expression of heat shock protein beta 1 enhanced insulin sensitivity in the skeletal muscle

(2016) Hairui Yuan et al.   FEBS LETTERS

Molecular networks in skeletal muscle plasticity

(2016) Hans Hoppeler   JOURNAL OF EXPERIMENTAL BIOLOGY

Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation

(2016) Andreas M. Fritzen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Myokine Expression in Muscle and Myotubes in Response to Exercise Stimulation

(2016) JEFFREY D. COVINGTON et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

The Nuclear Receptor, Nor-1, Induces the Physiological Responses Associated With Exercise

(2016) Joel M. Goode et al.   MOLECULAR ENDOCRINOLOGY

Muscle Contraction Induces Acute Hydroxymethylation of the Exercise-Responsive Gene Nr4a3

(2016) Pattarawan Pattamaprapanont et al.   Frontiers in Endocrinology

The exercise-regulated myokine chitinase-3-like protein 1 stimulates human myocyte proliferation

(2015) S. W. Görgens et al.   Acta Physiologica

Myotubes from lean and severely obese subjects with and without type 2 diabetes respond differently to an in vitro model of exercise

(2015) Yuan Z. Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Comparative effects of whey protein versus l-leucine on skeletal muscle protein synthesis and markers of ribosome biogenesis following resistance exercise

(2015) C. Brooks Mobley et al.   AMINO ACIDS

Exercise increases pancreatic β-cell viability in a model of type 1 diabetes through IL-6 signaling

(2015) Flavia M. M. Paula et al.   FASEB JOURNAL

Perilipin 3 Differentially Regulates Skeletal Muscle Lipid Oxidation in Active, Sedentary, and Type 2 Diabetic Males

(2015) Jeffrey D. Covington et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Skeletal Muscle to Pancreatic β-Cell Cross-talk: The Effect of Humoral Mediators Liberated by Muscle Contraction and Acute Exercise on β-Cell Apoptosis

(2015) Camilla S. Christensen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Activation of p38 in C2C12 myotubes following ATP depletion depends on extracellular glucose

(2015) Chia George Hsu et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Mechanical stretch activates mammalian target of rapamycin and AMP-activated protein kinase pathways in skeletal muscle cells

(2015) Naoya Nakai et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Abnormalities of AMPK Activation and Glucose Uptake in Cultured Skeletal Muscle Cells from Individuals with Chronic Fatigue Syndrome

(2015) Audrey E. Brown et al.   PLoS One

Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases

(2015) B. K. Pedersen et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Electric Pulse Stimulation of Myotubes as an In Vitro Exercise Model: Cell-Mediated and Non-Cell-Mediated Effects

(2015) Inkie J.A. Evers-van Gogh et al.   Scientific Reports

Role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle

(2014) Takashi Sasaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The myokine decorin is regulated by contraction and involved in muscle hypertrophy

(2014) Timo Kanzleiter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators

(2014) Yu-Chiang Lai et al.   BIOCHEMICAL JOURNAL

Integrative Biology of Exercise

(2014) John A. Hawley et al.   CELL

Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation

(2014) Sergej Pirkmajer et al.   DIABETES

New gene targets of PGC-1α and ERRα co-regulation in C2C12 myotubes

(2014) Abena Nsiah-Sefaa et al.   MOLECULAR BIOLOGY REPORTS

Exercise-mimicking treatment fails to increase Fndc5 mRNA & irisin secretion in primary human myotubes

(2014) Timea Kurdiova et al.   PEPTIDES

Skeletal Muscle Perilipin 3 and Coatomer Proteins Are Increased following Exercise and Are Associated with Fat Oxidation

(2014) Jeffrey D. Covington et al.   PLoS One

Cytokine response of primary human myotubes in an in vitro exercise model

(2013) Mika Scheler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle

(2013) Emmani BM Nascimento et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AICAR-induced activation of AMPK negatively regulates myotube hypertrophy through the HSP72-mediated pathway in C2C12 skeletal muscle cells

(2013) Tatsuro Egawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cessation of cyclic stretch induces atrophy of C2C12 myotubes

(2013) Quinlyn A. Soltow et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Are cultured human myotubes far from home?

(2013) Vigdis Aas et al.   CELL AND TISSUE RESEARCH

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

TRIB3 Mediates Glucose-Induced Insulin Resistance via a Mechanism That Requires the Hexosamine Biosynthetic Pathway

(2013) W. Zhang et al.   DIABETES

Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism

(2013) L. Salvadó et al.   DIABETOLOGIA

The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans

(2013) Frode Norheim et al.   FEBS Journal

Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine

(2013) A Besse-Patin et al.   INTERNATIONAL JOURNAL OF OBESITY

Enhanced Glucose Metabolism Is Preserved in Cultured Primary Myotubes From Obese Donors in Response to Exercise Training

(2013) Virginie Bourlier et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

AICAR inhibits oxygen consumption by intact skeletal muscle cells in culture

(2013) Espen E. Spangenburg et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Free fatty acid effects on myokine production in combination with exercise mimetics

(2013) Juana Sánchez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake

(2013) Erik A. Richter et al.   PHYSIOLOGICAL REVIEWS

Characterization of an Acute Muscle Contraction Model Using Cultured C2C12 Myotubes

(2013) Yasuko Manabe et al.   PLoS One

Identification and Validation of Novel Contraction-Regulated Myokines Released from Primary Human Skeletal Muscle Cells

(2013) Silja Raschke et al.   PLoS One

Evidence against a Beneficial Effect of Irisin in Humans

(2013) Silja Raschke et al.   PLoS One

AMPK Activation through Mitochondrial Regulation Results in Increased Substrate Oxidation and Improved Metabolic Parameters in Models of Diabetes

(2013) Yonchu Jenkins et al.   PLoS One

Regulation of follistatin-like protein 1 expression and secretion in primary human skeletal muscle cells

(2013) Sven W. Görgens et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Phosphorylation of adipose triglyceride lipase Ser404 is not related to 5′-AMPK activation during moderate-intensity exercise in humans

(2012) Rachael R. Mason et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMP-activated protein kinase stimulates myostatin expression in C2C12 cells

(2012) Arun K. Das et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle

(2012) Romain Barrès et al.   Cell Metabolism

Contractile activity of human skeletal muscle cells prevents insulin resistance by inhibiting pro-inflammatory signalling pathways

(2012) S. Lambernd et al.   DIABETOLOGIA

AMPK Enhances Insulin-Stimulated GLUT4 Regulation via Lowering Membrane Cholesterol

(2012) Kirk M. Habegger et al.   ENDOCRINOLOGY

Exercise alters mRNA expression of telomere-repeat binding factor 1 in skeletal muscle via p38 MAPK

(2012) Andrew T. Ludlow et al.   JOURNAL OF APPLIED PHYSIOLOGY

Contraction-induced Interleukin-6 Gene Transcription in Skeletal Muscle Is Regulated by c-Jun Terminal Kinase/Activator Protein-1

(2012) Martin Whitham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of AMP-activated Protein Kinase Stimulates Na+,K+-ATPase Activity in Skeletal Muscle Cells

(2012) Boubacar Benziane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myonectin (CTRP15), a Novel Myokine That Links Skeletal Muscle to Systemic Lipid Homeostasis

(2012) Marcus M. Seldin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Electrical Pulse Stimulation of Cultured Human Skeletal Muscle Cells as an In Vitro Model of Exercise

(2012) Nataša Nikolić et al.   PLoS One

Glucagon Like Peptide-1-Induced Glucose Metabolism in Differentiated Human Muscle Satellite Cells Is Attenuated by Hyperglycemia

(2012) Charlotte J. Green et al.   PLoS One

AICAR inhibits ceramide biosynthesis in skeletal muscle

(2012) Katherine A Erickson et al.   Diabetology & Metabolic Syndrome

Current understanding of increased insulin sensitivity after exercise - emerging candidates

(2011) S. J. Maarbjerg et al.   Acta Physiologica

An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle

(2011) Jonathan P. Little et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus

(2011) Sameer S. Kulkarni et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Remodeling Lipid Metabolism and Improving Insulin Responsiveness in Human Primary Myotubes

(2011) Lauren M. Sparks et al.   PLoS One

Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment

(2010) Benjamin T. Bikman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients

(2010) Magali Kitzmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Short-term AMP-regulated protein kinase activation enhances insulin-sensitive fatty acid uptake and increases the effects of insulin on fatty acid oxidation in L6 muscle cells

(2010) Karen R Kelly et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Electric Pulse Stimulation of Cultured Murine Muscle Cells Reproduces Gene Expression Changes of Trained Mouse Muscle

(2010) Nathalie Burch et al.   PLoS One

AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC

(2009) M. P. Sajan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Skeletal muscle NAMPT is induced by exercise in humans

(2009) Sheila R. Costford et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of contraction on localization of GLUT4 and v-SNARE isoforms in rat skeletal muscle

(2009) Adam J. Rose et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Calcineurin activates interleukin-6 transcription in mouse skeletal muscle in vivo and in C2C12 myotubes in vitro

(2009) David L. Allen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Blueberry fruit polyphenolics suppress oxidative stress-induced skeletal muscle cell damagein vitro

(2009) Roger D. Hurst et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Nitric oxide facilitates NFAT-dependent transcription in mouse myotubes

(2008) Jason A. Drenning et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NFAT activation by membrane potential follows a calcium pathway distinct from other activity-related transcription factors in skeletal muscle cells

(2008) Juan Antonio Valdés et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle

(2008) Taku Nedachi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exercise induces expression of leukaemia inhibitory factor in human skeletal muscle

(2008) Christa Broholm et al.   JOURNAL OF PHYSIOLOGY-LONDON

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

(2008) Bente K. Pedersen et al.   PHYSIOLOGICAL REVIEWS