Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments

Tetrahydroxystilbene glucoside inhibits TNF-α-induced migration of vascular smooth muscle cells via suppression of vimentin

(2016) Wenjuan Yao et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Tetrahydroxystilbene Glucoside Improves Neurotrophic Factors Release in Cultured Astroglia

(2016) FengQin Lin et al.   CNS & Neurological Disorders-Drug Targets

Tetrahydroxystilbene Glucoside Improves TNF-α-Induced Endothelial Dysfunction: Involvement of TGFβ/Smad Pathway and Inhibition of Vimentin Expression

(2015) Wenjuan Yao et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Activating mitochondrial function and haemoglobin expression with EH-201, an inducer of erythropoietin in neuronal cells, reverses memory impairment

(2015) Lin-Yea Horng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aortic Remodelling Is Improved by 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Involving the Smad3 Pathway in Spontaneously Hypertensive Rats

(2015) Ju Duan et al.   Evidence-based Complementary and Alternative Medicine

Proliferation of rat cardiac stem cells is induced by 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-d-glucoside in vitro

(2015) Fan Song et al.   LIFE SCIENCES

Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1

(2015) Xuanxuan Zhou et al.   NEUROBIOLOGY OF AGING

TSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese HerbPolygonum multiflorumIncreases Life Span and Stress Resistance ofCaenorhabditis elegans

(2015) Christian Büchter et al.   Oxidative Medicine and Cellular Longevity

Tetrahydroxystilbene Glucoside Protects Against Oxidized LDL-Induced Endothelial Dysfunction via Regulating Vimentin Cytoskeleton and its Colocalization with ICAM-1 and VCAM-1

(2014) Wenjuan Yao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibitory effects of 2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucoside on angiotensin II-induced proliferation of vascular smooth muscle cells

(2014) Xiao-le Xu et al.   Chinese Journal of Integrative Medicine

Efficacy of Antioxidants as a Complementary and Alternative Medicine (CAM) in Combination With the Chemotherapeutic Agent Doxorubicin

(2014) Ming-Thau Sheu et al.   INTEGRATIVE CANCER THERAPIES

2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside protects human umbilical vein endothelial cells against lysophosphatidylcholine-induced apoptosis by upregulating superoxide dismutase and glutathione peroxidase

(2014) Jing Zhao et al.   IUBMB LIFE

In vitro effects of active components of Polygonum Multiflorum Radix on enzymes involved in the lipid metabolism

(2014) Wangen Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Potential protection of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside against staurosporine-induced toxicity on cultured rat hippocampus neurons

(2014) Xiao-Ping Yang et al.   NEUROSCIENCE LETTERS

The Effect of 2,3,4′,5-Tetrahydroxystilbene-2-O-β-D-Glucoside on Pressure Overload-Induced Cardiac Remodeling in Rats and Its Possible Mechanism

(2014) Xiao Xu et al.   PLANTA MEDICA

Promotion effect of constituents from the root of Polygonum multiflorum on hair growth

(2013) Ya Nan Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation of mitochondrial function and Hb expression in non-haematopoietic cells by an EPO inducer ameliorates ischaemic diseases in mice

(2013) Pei-Lun Hsu et al.   BRITISH JOURNAL OF PHARMACOLOGY

2,3,4′,5-Tetrahydroxystilbene-2-O-β-D-glucoside Suppresses Expression of Adhesion Molecules in Aortic Wall of Dietary Atherosclerotic Rats and Promonocytic U937 Cells

(2013) Yu-Qin Wang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

TSG (2,3,4’ ,5-tetrahydroxystilbene 2-O-β-D-glucoside) suppresses induction of pro-inflammatory factors by attenuating the binding activity of nuclear factor-κB in microglia

(2013) Chao Huang et al.   Journal of Neuroinflammation

Tetrahydroxystilbene Glucoside Attenuates Neuroinflammation through the Inhibition of Microglia Activation

(2013) Feng Zhang et al.   Oxidative Medicine and Cellular Longevity

Protective effect of tetrahydroxystilbene glucoside against d-galactose induced aging process in mice

(2013) Xuan-Xuan Zhou et al.   Phytochemistry Letters

2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) attenuates human platelet aggregation, secretion and spreading in vitro

(2013) Ke Xiang et al.   THROMBOSIS RESEARCH

Neuroprotection by tetrahydroxystilbene glucoside in the MPTP mouse model of Parkinson's disease

(2013) Lingling Zhang et al.   TOXICOLOGY LETTERS

2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation

(2012) Xin Han et al.   ATHEROSCLEROSIS

Tetrahydroxystilbene glucoside improves the learning and memory of amyloid-β1–42-injected rats and may be connected to synaptic changes in the hippocampus

(2012) Lin Zhou et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

2,3,4′,5-Tetrahydroxystilbene-2-O-β-d-glucoside inhibits angiotensin II-induced cardiac fibroblast proliferation via suppression of the reactive oxygen species-extracellular signal-regulated kinase 1/2 pathway

(2012) Wei Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Protective effect of tetrahydroxystilbene glucoside against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells

(2012) Jin-Kang Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The effect of 2,3,4′,5-tetrahydroxystilbene-2-0-β-d glucoside on neointima formation in a rat artery balloon injury model and its possible mechanisms

(2012) Xiao-le Xu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

2, 3, 5, 4′-Tetrahydroxystilbene-2-O-Beta-D-Glucoside Improves Gastrointestinal Motility Disorders in STZ-Induced Diabetic Mice

(2012) Mu-Jun Chang et al.   PLoS One

2,3,4′,5-Tetrahydroxystilbene-2-O-β-d-glucoside inhibits platelet-derived growth factor-induced proliferation of vascular smooth muscle cells by regulating the cell cycle

(2011) Xiao-Le Xu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity

(2011) Fang-ling Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

2,3,4′,5-Tetrahydroxystilbene-2-O-β-d-glucoside Inhibits Proliferation of Vascular Smooth Muscle Cells: Involvement of NO/cGMP/PKG Pathway

(2011) Xiao-Le Xu et al.   PHYTOTHERAPY RESEARCH

Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+: The involvement of PI3K/Akt pathway activation

(2011) Rong Qin et al.   TOXICOLOGY LETTERS

Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: Involvement of SIRT1 and TGF-β1 pathway

(2010) Cairong Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tetrahydroxystilbene glucoside, a plant-derived cognitive enhancer, promotes hippocampal synaptic plasticity

(2010) Ting Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation

(2010) Xiaobing Li et al.   NEUROSCIENCE LETTERS

Protective effect of tetrahydroxystilbene glucoside on cardiotoxicity induced by doxorubicin in vitro and in vivo

(2009) Shao-hui Zhang et al.   ACTA PHARMACOLOGICA SINICA

Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS generation

(2009) Ting Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-d-glucoside (THSG) induces melanogenesis in B16 cells by MAP kinase activation and tyrosinase upregulation

(2009) Zequn Jiang et al.   LIFE SCIENCES

Effects of 2,3,4′,5-Tetrahydroxystilbene 2-O-β-D-Glucoside on Vascular Endothelial Dysfunction in Atherogenic-Diet Rats

(2009) Wei Zhang et al.   PLANTA MEDICA

Tetrahydroxy stilbene glucoside reduces the cognitive impairment and overexpression of amyloid precursor protein induced by aluminum exposure

(2009) Hong-Bo Luo et al.   Neuroscience Bulletin

A potent tyrosinase activator from Radix Polygoni multiflori and its melanogenesis stimulatory effect in B16 melanoma cells

(2008) Shuyu Guan et al.   PHYTOTHERAPY RESEARCH

2,3,4',5-TETRAHYDROXYSTILBENE-2-O-β-d-GLUCOSIDE SUPPRESSES MATRIX METALLOPROTEINASE EXPRESSION AND INFLAMMATION IN ATHEROSCLEROTIC RATS

(2007) Wei Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY