Promoting remyelination in multiple sclerosis: Current drugs and future prospects

An open-label phase II clinical trial of the RXR agonist IRX4204 in taxane-resistant, castration-resistant metastatic prostate cancer (CRPC).

(2017) Fairooz F. Kabbinavar et al.   JOURNAL OF CLINICAL ONCOLOGY

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

A phase II−III trial of olesoxime in subjects with amyotrophic lateral sclerosis

(2014) T. Lenglet et al.   EUROPEAN JOURNAL OF NEUROLOGY

Pegylated interferon beta-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study

(2014) Peter A Calabresi et al.   LANCET NEUROLOGY

ACTRIMS-ECTRIMS MSBoston 2014: Poster Sessions 2

(2014)   Multiple Sclerosis Journal

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

(2013) David Kremer et al.   ANNALS OF NEUROLOGY

Blocking LINGO-1 as a Therapy to Promote CNS Repair: From Concept to the Clinic

(2013) Sha Mi et al.   CNS DRUGS

Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire

(2013) Jens O Watzlawik et al.   Expert Review of Neurotherapeutics

Systemic Lack of Canonical Histamine Receptor Signaling Results in Increased Resistance to Autoimmune Encephalomyelitis

(2013) N. Saligrama et al.   JOURNAL OF IMMUNOLOGY

Disease-modifying treatments for progressive multiple sclerosis

(2013) Giancarlo Comi   Multiple Sclerosis Journal

A regenerative approach to the treatment of multiple sclerosis

(2013) Vishal A. Deshmukh et al.   NATURE

Fingolimod attenuates ceramide-induced blood–brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

(2012) Ruben van Doorn et al.   ACTA NEUROPATHOLOGICA

Cortical remyelination: A new target for repair therapies in multiple sclerosis

(2012) Ansi Chang et al.   ANNALS OF NEUROLOGY

Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice

(2012) Xiaoying Bi et al.   JOURNAL OF NEUROCHEMISTRY

Endogenous viruses: insights into viral evolution and impact on host biology

(2012) Cédric Feschotte et al.   NATURE REVIEWS GENETICS

Neuroprotection and repair in multiple sclerosis

(2012) Robin J. M. Franklin et al.   Nature Reviews Neurology

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination

(2012) Yanbo Zhang et al.   SCHIZOPHRENIA RESEARCH

The complex world of oligodendroglial differentiation inhibitors

(2011) David Kremer et al.   ANNALS OF NEUROLOGY

Olesoxime accelerates myelination and promotes repair in models of demyelination

(2011) Karine Magalon et al.   ANNALS OF NEUROLOGY

Myelin Regeneration: A Recapitulation of Development?

(2011) Stephen P.J. Fancy et al.   Annual Review of Neuroscience

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Sema4D as an inhibitory regulator in oligodendrocyte development

(2011) Wataru Yamaguchi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices

(2010) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

Epigenetic disruption of the WNT/ß-catenin signaling pathway in human cancers

(2010) Ying Ying et al.   Epigenetics

Overcoming remyelination failure in multiple sclerosis and other myelin disorders

(2010) Stephen P.J. Fancy et al.   EXPERIMENTAL NEUROLOGY

Retinoid X receptor gamma signaling accelerates CNS remyelination

(2010) Jeffrey K Huang et al.   NATURE NEUROSCIENCE

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Human Endogenous Retrovirus Link between Genes and Environment in Multiple Sclerosis and in Multifactorial Diseases Associating Neuroinflammation

(2009) Hervé Perron et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

(2009) Bruce D Trapp et al.   LANCET NEUROLOGY

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Central nervous system-directed effects of FTY720 (fingolimod)

(2008) Veronique E. Miron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES