Genetic variants in Alzheimer disease — molecular and brain network approaches

Post-GWAS methodologies for localisation of functional non-coding variants: ANGPTL3

(2016) Federico Oldoni et al.   ATHEROSCLEROSIS

Factors affecting characterization and localization of interindividual differences in functional connectivity using MRI

(2016) Raag D. Airan et al.   HUMAN BRAIN MAPPING

High-throughput mapping of regulatory DNA

(2016) Nisha Rajagopal et al.   NATURE BIOTECHNOLOGY

Gray matter network disruptions and amyloid beta in cognitively normal adults

(2016) Betty M. Tijms et al.   NEUROBIOLOGY OF AGING

Dynamic fluctuations coincide with periods of high and low modularity in resting-state functional brain networks

(2016) Richard F. Betzel et al.   NEUROIMAGE

Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex

(2016) S.A. Neymotin et al.   NEUROSCIENCE

Exome-sequencing in a large dataset of late-onset families with Alzheimer’s disease

(2015) Dan Kobolt et al.   Alzheimers & Dementia

Coding mutations inSORL1and Alzheimer disease

(2015) Badri N. Vardarajan et al.   ANNALS OF NEUROLOGY

Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci

(2015) Badri N. Vardarajan et al.   ANNALS OF NEUROLOGY

Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

(2015) Stéphanie Debette et al.   BIOLOGICAL PSYCHIATRY

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Reconstruction and Simulation of Neocortical Microcircuitry

(2015) Henry Markram et al.   CELL

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

(2015) Nidhi Sahni et al.   CELL

Saturated Reconstruction of a Volume of Neocortex

(2015) Narayanan Kasthuri et al.   CELL

Identifying patients with Alzheimer’s disease using resting-state fMRI and graph theory

(2015) Ali Khazaee et al.   CLINICAL NEUROPHYSIOLOGY

Computational models in the age of large datasets

(2015) Timothy O’Leary et al.   CURRENT OPINION IN NEUROBIOLOGY

Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models

(2015) Terry C. Burns et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bayesian Network Reconstruction Using Systems Genetics Data: Comparison of MCMC Methods

(2015) Shinya Tasaki et al.   GENETICS

Apolipoprotein E ε4 modulates functional brain connectome in Alzheimer's disease

(2015) Jinhui Wang et al.   HUMAN BRAIN MAPPING

Disrupted rich club network in behavioral variant frontotemporal dementia and early-onset Alzheimer's disease

(2015) Madelaine Daianu et al.   HUMAN BRAIN MAPPING

Rich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network

(2015) Madelaine Daianu et al.   HUMAN BRAIN MAPPING

A multi-scale approach to designing therapeutics for tuberculosis

(2015) Jennifer J. Linderman et al.   Integrative Biology

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

(2015) G Davies et al.   MOLECULAR PSYCHIATRY

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Common genetic variants influence human subcortical brain structures

(2015) Derrek P. Hibar et al.   NATURE

A multilevel multimodal circuit enhances action selection in Drosophila

(2015) Tomoko Ohyama et al.   NATURE

Large-scale identification of sequence variants influencing human transcription factor occupancy in vivo

(2015) Matthew T Maurano et al.   NATURE GENETICS

Understanding multicellular function and disease with human tissue-specific networks

(2015) Casey S Greene et al.   NATURE GENETICS

dSysMap: exploring the edgetic role of disease mutations

(2015) Roberto Mosca et al.   NATURE METHODS

The PsychENCODE project

(2015) Schahram Akbarian et al.   NATURE NEUROSCIENCE

Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders

(2015) Neelroop N. Parikshak et al.   NATURE REVIEWS GENETICS

Late-onset Alzheimer’s risk variants in memory decline, incident mild cognitive impairment, and Alzheimer’s disease

(2015) Minerva M. Carrasquillo et al.   NEUROBIOLOGY OF AGING

Genome-wide interaction analysis reveals replicated epistatic effects on brain structure

(2015) Derrek P. Hibar et al.   NEUROBIOLOGY OF AGING

Divergent brain functional network alterations in dementia with Lewy bodies and Alzheimer's disease

(2015) Luis R. Peraza et al.   NEUROBIOLOGY OF AGING

Connectivity network measures predict volumetric atrophy in mild cognitive impairment

(2015) Talia M. Nir et al.   NEUROBIOLOGY OF AGING

A Large-Scale Circuit Mechanism for Hierarchical Dynamical Processing in the Primate Cortex

(2015) Rishidev Chaudhuri et al.   NEURON

Dynamic Resting-State Functional Connectivity in Major Depression

(2015) Roselinde H Kaiser et al.   NEUROPSYCHOPHARMACOLOGY

Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume and Functional Connectivity in Young Healthy Individuals

(2015) Xiaolong Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Effect of APOE and CD33 on Cognitive Decline

(2015) Kathleen M. Hayden et al.   PLoS One

Choosing experiments to accelerate collective discovery

(2015) Andrey Rzhetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time

(2015) Jihwan Myung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ongoing dynamics in large-scale functional connectivity predict perception

(2015) Sepideh Sadaghiani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping

(2015) Daniel DeWoskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signature of consciousness in the dynamics of resting-state brain activity

(2015) Pablo Barttfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Sharing and Specificity of Co-expression Networks across 35 Human Tissues

(2015) Emma Pierson et al.   PLoS Computational Biology

Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble

(2015) Renaud Jolivet et al.   PLoS Computational Biology

Bayesian Network Reconstruction Using Systems Genetics Data: Comparison of MCMC Methods

(2015) Shinya Tasaki et al.   GENETICS

Altered whole-brain white matter networks in preclinical Alzheimer's disease

(2015) Florian Udo Fischer et al.   NeuroImage-Clinical

ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology

(2014) Peter T. Nelson et al.   ACTA NEUROPATHOLOGICA

The hubs of the human connectome are generally implicated in the anatomy of brain disorders

(2014) Nicolas A. Crossley et al.   BRAIN

Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer’s disease

(2014) Nicholas Myers et al.   BRAIN

A Proteome-Scale Map of the Human Interactome Network

(2014) Thomas Rolland et al.   CELL

Identifying and Mapping Connectivity Patterns of Brain Network Hubs in Alzheimer's Disease

(2014) Zhengjia Dai et al.   CEREBRAL CORTEX

New applications of disease genetics and pharmacogenetics to drug development

(2014) Allen D Roses et al.   CURRENT OPINION IN PHARMACOLOGY

Simulated rich club lesioning in brain networks: a scaffold for communication and integration?

(2014) Marcel A. de Reus et al.   Frontiers in Human Neuroscience

Dynamic connectivity states estimated from resting fMRI Identify differences among Schizophrenia, bipolar disorder, and healthy control subjects

(2014) Barnaly Rashid et al.   Frontiers in Human Neuroscience

The discovery of integrated gene networks for autism and related disorders

(2014) Fereydoun Hormozdiari et al.   GENOME RESEARCH

Heritability of structural brain network topology: A DTI study of 156 twins

(2014) Marc M. Bohlken et al.   HUMAN BRAIN MAPPING

Coding variants in TREM2 increase risk for Alzheimer's disease

(2014) Sheng Chih Jin et al.   HUMAN MOLECULAR GENETICS

Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study

(2014) Clifford R Jack et al.   LANCET NEUROLOGY

Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes

(2014) Mark D M Leiserson et al.   NATURE GENETICS

The big data challenges of connectomics

(2014) Jeff W Lichtman et al.   NATURE NEUROSCIENCE

Genome-wide association interaction analysis for Alzheimer's disease

(2014) Elena S. Gusareva et al.   NEUROBIOLOGY OF AGING

Decoding Wakefulness Levels from Typical fMRI Resting-State Data Reveals Reliable Drifts between Wakefulness and Sleep

(2014) Enzo Tagliazucchi et al.   NEURON

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

(2014) Valentina Escott-Price et al.   PLoS One

Experimental evidence of massive-scale emotional contagion through social networks

(2014) A. D. I. Kramer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Time-resolved resting-state brain networks

(2014) A. Zalesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

(2014) T. Raj et al.   SCIENCE

The A4 Study: Stopping AD Before Symptoms Begin?

(2014) R. A. Sperling et al.   Science Translational Medicine

Electrostimulation to reduce synaptic scaling driven progression of Alzheimer's disease

(2014) Mark S. Rowan et al.   Frontiers in Computational Neuroscience

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Functional disorganization of small-world brain networks in mild Alzheimer's Disease and amnestic Mild Cognitive Impairment: an EEG study using Relative Wavelet Entropy (RWE)

(2014) Christos A. Frantzidis et al.   Frontiers in Aging Neuroscience

Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders

(2014) Eric E. Schadt et al.   Frontiers in Pharmacology

Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans?

(2014) Rafael Franco et al.   Frontiers in Pharmacology

Dissecting Disease Inheritance Modes in a Three-Dimensional Protein Network Challenges the “Guilt-by-Association” Principle

(2013) Yu Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Much of late life cognitive decline is not due to common neurodegenerative pathologies

(2013) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

Assessing identity, redundancy and confounds in Gene Ontology annotations over time

(2013) Jesse Gillis et al.   BIOINFORMATICS

Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network

(2013) Suleyman Gulsuner et al.   CELL

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Structural connectivity in schizophrenia and its impact on the dynamics of spontaneous functional networks

(2013) Joana Cabral et al.   CHAOS

The use and abuse of large-scale brain models

(2013) Chris Eliasmith et al.   CURRENT OPINION IN NEUROBIOLOGY

Molecular computation in neurons: a modeling perspective

(2013) Upinder S Bhalla   CURRENT OPINION IN NEUROBIOLOGY

Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders

(2013) C. Gaiteri et al.   GENES BRAIN AND BEHAVIOR

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

(2013) Carlos Cruchaga et al.   NATURE

A community-driven global reconstruction of human metabolism

(2013) Ines Thiele et al.   NATURE BIOTECHNOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Network-based stratification of tumor mutations

(2013) Matan Hofree et al.   NATURE METHODS

Integrative approaches for finding modular structure in biological networks

(2013) Koyel Mitra et al.   NATURE REVIEWS GENETICS

Functional connectivity and graph theory in preclinical Alzheimer's disease

(2013) Matthew R. Brier et al.   NEUROBIOLOGY OF AGING

Dynamic functional connectivity: Promise, issues, and interpretations

(2013) R. Matthew Hutchison et al.   NEUROIMAGE

Comparing connectivity pattern and small-world organization between structural correlation and resting-state networks in healthy adults

(2013) S.M. Hadi Hosseini et al.   NEUROIMAGE

Life-span cognitive activity, neuropathologic burden, and cognitive aging

(2013) R. S. Wilson et al.   NEUROLOGY

Impaired default network functional connectivity in autosomal dominant Alzheimer disease

(2013) J. P. Chhatwal et al.   NEUROLOGY

Bilingualism delays age at onset of dementia, independent of education and immigration status

(2013) S. Alladi et al.   NEUROLOGY

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Monetary Costs of Dementia in the United States

(2013) Michael D. Hurd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-Subject Grey Matter Graphs in Alzheimer's Disease

(2013) Betty M. Tijms et al.   PLoS One

Whole-brain Functional Networks in Cognitively Normal, Mild Cognitive Impairment, and Alzheimer’s Disease

(2013) Eun Hyun Seo et al.   PLoS One

Exploring the Functional Brain Network of Alzheimer’s Disease: Based on the Computational Experiment

(2013) YaPeng Li et al.   PLoS One

Alzheimer’s Disease: Analyzing the Missing Heritability

(2013) Perry G. Ridge et al.   PLoS One

Spatially clustered neuronal assemblies comprise the microstructure of synchrony in chronically epileptic networks

(2013) Sarah Feldt Muldoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atypical Combinations and Scientific Impact

(2013) B. Uzzi et al.   SCIENCE

The NIH BRAIN Initiative

(2013) T. R. Insel et al.   SCIENCE

Genes and pathways underlying regional and cell type changes in Alzheimer's disease

(2013) Jeremy A Miller et al.   Genome Medicine

Dissection of Regulatory Networks that Are Altered in Disease via Differential Co-expression

(2013) David Amar et al.   PLoS Computational Biology

An Inflection Point in Gene Discovery Efforts for Neurodegenerative Diseases

(2013) Philip L. De Jager et al.   JAMA Neurology

Brain Differences in Infants at Differential Genetic Risk for Late-Onset Alzheimer Disease

(2013) Douglas C. Dean et al.   JAMA Neurology

The Virtual Brain: a simulator of primate brain network dynamics

(2013) Paula Sanz Leon et al.   Frontiers in Neuroinformatics

The genetics and neuropathology of Alzheimer’s disease

(2012) Gerard D. Schellenberg et al.   ACTA NEUROPATHOLOGICA

Alzheimer Disease Susceptibility Loci: Evidence for a Protein Network under Natural Selection

(2012) Towfique Raj et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Physical Activity and AD-Related Pathology—Reply

(2012) Susan Landau et al.   ARCHIVES OF NEUROLOGY

Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer's Disease

(2012) Jinhui Wang et al.   BIOLOGICAL PSYCHIATRY

HINT: High-quality protein interactomes and their applications in understanding human disease

(2012) Jishnu Das et al.   BMC Systems Biology

Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers

(2012) Krishna T. Patel et al.   Brain Imaging and Behavior

A Whole-Cell Computational Model Predicts Phenotype from Genotype

(2012) Jonathan R. Karr et al.   CELL

The Cell-Type Specific Cortical Microcircuit: Relating Structure and Activity in a Full-Scale Spiking Network Model

(2012) Tobias C. Potjans et al.   CEREBRAL CORTEX

Tracking Whole-Brain Connectivity Dynamics in the Resting State

(2012) Elena A. Allen et al.   CEREBRAL CORTEX

Genetic control of functional brain network efficiency in children

(2012) Martijn P. van den Heuvel et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Using a million cell simulation of the cerebellum: Network scaling and task generality

(2012) Wen-Ke Li et al.   NEURAL NETWORKS

Screening of the SOD1, FUS, TARDBP, ANG, and OPTN mutations in Korean patients with familial and sporadic ALS

(2012) Min-Jung Kwon et al.   NEUROBIOLOGY OF AGING

Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease

(2012) James M. Bullock et al.   NEUROBIOLOGY OF AGING

Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population

(2012) Mia Kero et al.   NEUROBIOLOGY OF AGING

Association between heart rate variability and fluctuations in resting-state functional connectivity

(2012) Catie Chang et al.   NEUROIMAGE

Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory

(2012) S. Barral et al.   NEUROLOGY

Total daily physical activity and the risk of AD and cognitive decline in older adults

(2012) A.S. Buchman et al.   NEUROLOGY

Mapping the Human Connectome

(2012) Arthur W. Toga et al.   NEUROSURGERY

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Variant TREM2 as Risk Factor for Alzheimer's Disease

(2012) Harald Neumann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disrupted Small-World Brain Networks in Moderate Alzheimer's Disease: A Resting-State fMRI Study

(2012) Xiaohu Zhao et al.   PLoS One

Non-Stationarity in the “Resting Brain’s” Modular Architecture

(2012) David T. Jones et al.   PLoS One

Competitive and cooperative dynamics of large-scale brain functional networks supporting recollection

(2012) A. Fornito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-cost, high-capacity backbone for global brain communication

(2012) M. P. van den Heuvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small world of weak ties provides optimal global integration of self-similar modules in functional brain networks

(2012) L. K. Gallos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia

(2012) A. Anticevic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Social contagion theory: examining dynamic social networks and human behavior

(2012) Nicholas A. Christakis et al.   STATISTICS IN MEDICINE

Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology

(2012) Herve Rhinn et al.   Nature Communications

Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges

(2012) Purvesh Khatri et al.   PLoS Computational Biology

Enhancing the Prioritization of Disease-Causing Genes through Tissue Specific Protein Interaction Networks

(2012) Oded Magger et al.   PLoS Computational Biology

Activity Dependent Degeneration Explains Hub Vulnerability in Alzheimer's Disease

(2012) Willem de Haan et al.   PLoS Computational Biology

Epistasis network centrality analysis yields pathway replication across two GWAS cohorts for bipolar disorder

(2012) A Pandey et al.   Translational Psychiatry

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

The Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception

(2011) Michael W. Weiner et al.   Alzheimers & Dementia

Lack of Evidence for the Efficacy of Memantine in Mild Alzheimer Disease

(2011) Lon S. Schneider   ARCHIVES OF NEUROLOGY

Characterizing genetic interactions in human disease association studies using statistical epistasis networks

(2011) Ting Hu et al.   BMC BIOINFORMATICS

The Association between a Polygenic Alzheimer Score and Cortical Thickness in Clinically Normal Subjects

(2011) Mert R. Sabuncu et al.   CEREBRAL CORTEX

Functional brain network efficiency predicts intelligence

(2011) Nicolas Langer et al.   HUMAN BRAIN MAPPING

A Multiscale Simulation System for the Prediction of Drug-Induced Cardiotoxicity

(2011) Cristian Obiol-Pardo et al.   Journal of Chemical Information and Modeling

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

The effects of APOE on the functional architecture of the resting brain

(2011) Aaron J. Trachtenberg et al.   NEUROIMAGE

Age-related changes in the default mode network are more advanced in Alzheimer disease

(2011) D. T. Jones et al.   NEUROLOGY

The Impact of Multifunctional Genes on "Guilt by Association" Analysis

(2011) Jesse Gillis et al.   PLoS One

Functional Disconnection and Compensation in Mild Cognitive Impairment: Evidence from DLPFC Connectivity Using Resting-State fMRI

(2011) Peipeng Liang et al.   PLoS One

CR1is associated with amyloid plaque burden and age-related cognitive decline

(2010) Lori B. Chibnik et al.   ANNALS OF NEUROLOGY

Toward the dynamic interactome: it's about time

(2010) T. M. Przytycka et al.   BRIEFINGS IN BIOINFORMATICS

Diffusion Tensor Tractography Reveals Abnormal Topological Organization in Structural Cortical Networks in Alzheimer's Disease

(2010) C.-Y. Lo et al.   JOURNAL OF NEUROSCIENCE

APOE4 Allele Disrupts Resting State fMRI Connectivity in the Absence of Amyloid Plaques or Decreased CSF A 42

(2010) Y. I. Sheline et al.   JOURNAL OF NEUROSCIENCE

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

(2010) Juha O Rinne et al.   LANCET NEUROLOGY

Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks

(2010) Xionglei He et al.   NATURE GENETICS

A hybrid approach to multi-scale modelling of cancer

(2010) J. M. Osborne et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Altered Gene Synchrony Suggests a Combined Hormone-Mediated Dysregulated State in Major Depression

(2010) Chris Gaiteri et al.   PLoS One

Loss of ‘Small-World’ Networks in Alzheimer's Disease: Graph Analysis of fMRI Resting-State Functional Connectivity

(2010) Ernesto J. Sanz-Arigita et al.   PLoS One

Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways

(2010) Jeremy A. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circuit topology for synchronizing neurons in spontaneously active networks

(2010) N. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects

(2010) Kristel Sleegers et al.   TRENDS IN GENETICS

From ‘differential expression’ to ‘differential networking’ – identification of dysfunctional regulatory networks in diseases

(2010) Alberto de la Fuente   TRENDS IN GENETICS

Abnormal Cortical Networks in Mild Cognitive Impairment and Alzheimer's Disease

(2010) Zhijun Yao et al.   PLoS Computational Biology

Epistasis and Its Implications for Personal Genetics

(2009) Jason H. Moore et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The neuropathology of probable Alzheimer disease and mild cognitive impairment

(2009) Julie A. Schneider et al.   ANNALS OF NEUROLOGY

A Computational Model for Cerebral Cortical Dysfunction in Autism Spectrum Disorders

(2009) Shashaank Vattikuti et al.   BIOLOGICAL PSYCHIATRY

Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory

(2009) Willem de Haan et al.   BMC NEUROSCIENCE

Genetic foundations of human intelligence

(2009) Ian J. Deary et al.   HUMAN GENETICS

Efficiency of Functional Brain Networks and Intellectual Performance

(2009) M. P. van den Heuvel et al.   JOURNAL OF NEUROSCIENCE

Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease

(2009) R. L. Buckner et al.   JOURNAL OF NEUROSCIENCE

Edgetic perturbation models of human inherited disorders

(2009) Quan Zhong et al.   Molecular Systems Biology

A configurable simulation environment for the efficient simulation of large-scale spiking neural networks on graphics processors

(2009) Jayram Moorkanikara Nageswaran et al.   NEURAL NETWORKS

Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)

(2009) Jessica B.S. Langbaum et al.   NEUROIMAGE

Neural correlates of Alzheimer's disease and mild cognitive impairment: A systematic and quantitative meta-analysis involving 1351 patients

(2009) Matthias L. Schroeter et al.   NEUROIMAGE

Cognitive activities delay onset of memory decline in persons who develop dementia

(2009) C. B. Hall et al.   NEUROLOGY

Distinct patterns of brain activity in young carriers of the APOE- 4 allele

(2009) N. Filippini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential

(2009) J. R. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predicting human resting-state functional connectivity from structural connectivity

(2009) C. J. Honey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GABAergic Hub Neurons Orchestrate Synchrony in Developing Hippocampal Networks

(2009) P. Bonifazi et al.   SCIENCE

Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease

(2009) Radu Dobrin et al.   GENOME BIOLOGY

Walking the Interactome for Prioritization of Candidate Disease Genes

(2008) Sebastian Köhler et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease

(2008) C. J. Stam et al.   BRAIN

Structural Insights into Aberrant Topological Patterns of Large-Scale Cortical Networks in Alzheimer's Disease

(2008) Y. He et al.   JOURNAL OF NEUROSCIENCE

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

(2008) Lars Bertram et al.   NATURE REVIEWS NEUROSCIENCE

Epistasis in sporadic Alzheimer's disease

(2008) Onofre Combarros et al.   NEUROBIOLOGY OF AGING

Network properties of genes harboring inherited disease mutations

(2008) I. Feldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale model of mammalian thalamocortical systems

(2008) E. M. Izhikevich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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