High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells

Angiotensin-(1–7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice

(2015) Yixuan Shi et al.   CLINICAL SCIENCE

Vascular Induction of a Disintegrin and Metalloprotease 17 by Angiotensin II Through Hypoxia Inducible Factor 1α

(2014) Takashi Obama et al.   AMERICAN JOURNAL OF HYPERTENSION

Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in Endoplasmic Reticulum Stress and an Increase in Autophagy

(2014) Ming-Zhi Zhang et al.   DIABETES

High Glucose-inducedO-GlcNAcylated Carbohydrate Response Element-binding Protein (ChREBP) Mediates Mesangial Cell Lipogenesis and Fibrosis

(2014) Min-Jung Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Hypoxia-Inducible Factors Prevents Diabetic Nephropathy

(2014) L. Nordquist et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of Src Kinase Blocks High Glucose-Induced EGFR Transactivation and Collagen Synthesis in Mesangial Cells and Prevents Diabetic Nephropathy in Mice

(2013) K. Taniguchi et al.   DIABETES

Low nitric oxide bioavailability upregulates renal heparin binding EGF-like growth factor expression

(2013) Tomoki Miyazawa et al.   KIDNEY INTERNATIONAL

Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1α

(2013) Keiichiro Matoba et al.   KIDNEY INTERNATIONAL

Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo

(2013) Masaki Yoda et al.   PLoS One

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

HIF-1α dysfunction in diabetes

(2011) Hariharan Thangarajah et al.   CELL CYCLE

Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways

(2011) Hongmei Yu et al.   JOURNAL OF APPLIED TOXICOLOGY

Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy

(2011) ANDREW ADVANI et al.   NEPHROLOGY

p75 Neurotrophin Receptor-mediated Apoptosis in Sympathetic Neurons Involves a Biphasic Activation of JNK and Up-regulation of Tumor Necrosis Factor-α-converting Enzyme/ADAM17

(2010) Rajappa S. Kenchappa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein

(2010) Tsubasa Isoe et al.   KIDNEY INTERNATIONAL

Tumor necrosis factor-α as a therapeutic target for diabetic nephropathy

(2009) Juan F. Navarro-González et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Novel TACE inhibitors in drug discovery: a review of patented compounds

(2009) Prashant R Murumkar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia

(2009) Alexandra Szalad et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PKC- 1 Mediates Glucose-Induced Akt Activation and TGF- 1 Upregulation in Mesangial Cells

(2009) D. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY