Article
Biochemistry & Molecular Biology
Rongjun Jia, Fan Yang, Pengfei Yan, Liman Ma, Longfei Yang, Lihua Li
Summary: The study demonstrated that paricalcitol alleviated cholestatic liver injury by promoting the repair of damaged bile ducts and reducing oxidative stress-induced cell senescence. Mechanistic analysis revealed that paricalcitol exerted its protective effects through modulating the Sirt1 pathway in bile duct cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Christiana Magkrioti, Georgia Antonopoulou, Dionysios Fanidis, Vaia Pliaka, Theodore Sakellaropoulos, Leonidas G. Alexopoulos, Christoph Ullmer, Vassilis Aidinis
Summary: This study investigated the response of human proximal tubular epithelial cells to LPA and other pathological stimuli, identifying signaling pathways and inflammatory factors that may play a role in the pathogenesis of CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Junfeng Ke, Wenzhao Han, Fanwei Meng, Feng Guo, Yuhong Wang, Liping Wang
Summary: Studies have shown that CTI-2 inhibits the activation of the MAPK signaling pathway, reduces the expression of E-cadherin, N-cadherin, and vimentin, thus preventing the metastasis of breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Megan Lo, Amnon Sharir, Michael D. Paul, Hayarpi Torosyan, Christopher Agnew, Amy Li, Cynthia Neben, Pauline Marangoni, Libin Xu, David R. Raleigh, Natalia Jura, Ophir D. Klein
Summary: The protein Canopy4 has been found to regulate the level of membrane sterol lipids, and its absence in mouse embryos leads to developmental defects related to Hedgehog (Hh) signaling, particularly changes in digit number. This study reveals a previously unknown aspect of Hh pathway regulation through control of membrane composition.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yi-Shin Wu, Chian-Ruei Chen, Yun-Ting Yeh, Han-Huei Lin, Yin-Hsuan Peng, Yu-Ling Lin
Summary: DMGF inhibits the production of proinflammatory cytokines and the migration of inflammatory cells, potentially through downregulation of estrogen receptor alpha signaling.
Article
Cell Biology
Ying Yang, Chensheng Li, Xia Gu, Junhui Zhen, Suwei Zhu, Tingting Lv, Qiang Wan, Yi Liu
Summary: The study demonstrated that ING2 plays a crucial role in modulating mitochondrial respiration of TECs by regulating mtDNA transcription and the abundance of respiratory chain components. ING2 also showed to be involved in the ubiquitination of mitochondrial transcription factor MRPL12, affecting TEC mitochondrial function. Additionally, ING2-mediated modulation on mtDNA transcription and mitochondrial respiration were found to be associated with TEC injuries induced by serum deprivation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ying Yang, Chensheng Li, Xia Gu, Junhui Zhen, Suwei Zhu, Tingting Lv, Qiang Wan, Yi Liu
Summary: ING2 plays a crucial role in regulating mitochondrial respiration in tubular epithelial cells, potentially maintaining mitochondrial homeostasis by modulating mtDNA transcription and respiratory chain components. Additionally, ING2 regulates the ubiquitination of a mitochondrial transcription factor MRPL12, and has a protective effect on tubular epithelial cells against acute ischemic injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Urology & Nephrology
Eva Dizin, Valerie Olivier, Isabelle Roth, Ali Sassi, Gregoire Arnoux, Suresh Ramakrishnan, Sandrine Morel, Brenda R. Kwak, Johannes Loffing, Edith Hummler, Roland H. Wenger, Ian J. Frew, Eric Feraille
Summary: The study demonstrates that HIF pathway regulates ENaC expression and activity, potentially serving as a negative feedback mechanism to maintain oxygenation and prevent excessive ROS generation under increased sodium transport.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
C. Kent-Dennis, G. B. Penner
Summary: The study investigated the effects of LPS on the metabolism of short-chain fatty acids by primary ruminal epithelial cells (REC) and the impact of media containing short-chain fatty acids on the proinflammatory response. The results showed changes in cellular processes such as nutrient absorption, gene expression, and glucose metabolism when REC were exposed to LPS. Additionally, altered expression of specific genes and proteins associated with inflammation and metabolism was observed in response to LPS exposure and different media compositions.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Plant Sciences
Hang Chen, Ji Zhu, Yifei Le, Jieli Pan, Ying Liu, Zhijun Liu, Cui Wang, Xiaobing Dou, Dezhao Lu
Summary: Salidroside has been shown to have cardioprotective effects against doxorubicin-induced cardiomyopathy by activating AMPK-dependent signaling pathways. It reduces ferroptotic cell death and shows potential as a novel treatment for DIC.
Article
Nutrition & Dietetics
Meng-Ling Zhang, Qian Yang, Yan-Di Zhu, Ya-Di Zhang, Rui Zhang, Jian Liu, Xiao-Yan Zhao, Qin-Yu Dang, Dong-Xu Huang, Ming-Yuan Zhang, Yu-Chen Wei, Zhuo Hu, Xia-Xia Cai, Li-Fang Gao, Yang Shan, Huan-Ling Yu
Summary: This study aimed to evaluate the effects of Nobiletin (NOB) on placental damage in SD rats that underwent RUPP surgery and to assess the safety of NOB intervention during pregnancy. The results showed that NOB alleviated placental hypoxia and apoptosis, and inhibited placental damage. NOB intervention during pregnancy did not cause any side effects. Additionally, the P53 signaling pathway was found to be critical for NOB to reduce hypoxia-induced apoptosis in BeWo cell lines. In summary, NOB attenuated hypoxia-induced placental damage by regulating the P53 signaling pathway, providing insights into the role of NOB in placental development and preventing placental-related diseases.
Article
Dermatology
Shokei Murakami, Kyoko Futamura, Kenji Matsumoto, Yuichi Adachi, Akio Matsuda
Summary: This study found that a homogenate of epidermal keratinocytes significantly induced AD-related cytokines in cultured dermal cells, and IL-1 alpha might be involved in that induction. The combined use of corticosteroids and JAK1 inhibitors is likely to block the itch-scratch cycle by targeting different types of dermal cells.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Katharina Thomas, Lisa Zondler, Nadine Ludwig, Marina Kardell, Corinna Lueneburg, Katharina Henke, Sina Mersmann, Andreas Margraf, Tilmann Spieker, Tobias Tekath, Ana Velic, Richard Holtmeier, Juliane Hermann, Vera Jankowski, Melanie Meersch, Dietmar Vestweber, Martin Westphal, Johannes Roth, Michael A. Schaefers, John A. Kellum, Clifford A. Lowell, Jan Rossaint, Alexander Zarbock
Summary: Glutamine administration significantly reduces kidney damage and improves kidney function in a murine model of AKI. Glutamine causes transcriptomic and proteomic reprogramming in renal tubular epithelial cells, leading to decreased apoptosis, decreased neutrophil recruitment, and improved mitochondrial functionality. The proteins Tgm2 and Ask1 play important roles in the apoptotic signaling pathway targeted by glutamine.
Article
Medicine, Research & Experimental
Minmin Gong, Yujin Guo, Hui Dong, Wenbin Wu, Fan Wu, Fuer Lu
Summary: This study demonstrates that trigonelline can attenuate tubular epithelial-mesenchymal transition and renal fibrosis in diabetic mice, potentially by upregulating Smad7 in proximal tubule epithelial cells. These findings suggest the potential of trigonelline as a promising medicine against diabetic kidney disease.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Shouhai Wu, Meixia Yan, Junyi Liu, Yizhen Li, Ruimin Tian, Chuang Li, Lihuang Huang, Zhisheng Lu, Peng Xu, Wei Mao
Summary: The traditional Chinese medicinal herb, Clerodendranthus spicatus, can reduce serum uric acid and ameliorate renal function in the treatment of hyperuricaemic nephropathy. In vivo and in vitro studies showed that Clerodendranthus spicatus inhibits fibrosis in renal cells, leading to the protection of renal function.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Transplantation
Alberto Ortiz, Charles J. Ferro, Olga Balafa, Michel Burnier, Robert Ekart, Jean-Michel Halimi, Reinhold Kreutz, Patrick B. Mark, Alexandre Persu, Patrick Rossignol, Luis M. Ruilope, Roland E. Schmieder, Jose M. Valdivielso, Lucia Del Vecchio, Carmine Zoccali, Francesca Mallamaci, Pantelis Sarafidis
Summary: Diabetic kidney disease (DKD) is the most common cause of chronic kidney disease (CKD), with high risks of kidney failure and cardiovascular death for patients with CKD, especially those with diabetes. Renin-angiotensin system (RAS) blockers and sodium-glucose co-transporter-2 inhibitors (SGLT2is) have shown some protective effects, but the risks remain high. Steroidal mineralocorticoid receptor antagonists (MRAs) may provide potential benefits, but safety concerns exist. The FInerenone in reducing kiDnEy faiLure and dIsease prOgression in DKD (FIDELIO-DKD) study has shown promising results for non-steroidal MRA finerenone.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Peripheral Vascular Disease
Maria del Mar Vila, Laura Igual, Beatriz Remeseiro, Roberto Elosua, Rafel Ramos, Jose M. Valdivielso, Ruth Marti-Lluch, Jaume Marrugat, Maria Grau
Summary: This study assessed the correlation between biomarkers of lower limb atherosclerosis and carotid atherosclerosis. The results showed a linear trend between ankle-brachial index and common carotid intima-media thickness in men, and women with peripheral artery disease had a higher risk of atherosclerotic plaque in the carotid artery.
Article
Cardiac & Cardiovascular Systems
Kunihiro Matsushita, Stephen Kaptoge, Steven H. J. Hageman, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Aditya Surapaneni, Luanluan Sun, Johan Arnlov, Milica Bozic, Hermann Brenner, Nigel J. Brunskill, Alex R. Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai Uwe Eckardt, Ron T. Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih Jen Hwang, Tazeen H. Jafar, Simerjot K. Jassal, Takamasa Kayama, Csaba P. Kovesdy, Gijs W. Landman, Andrew S. Levey, Donald M. Lloyd-Jones, Rupert W. Major, Katsuyuki Miura, Paul Muntner, Girish N. Nadkarni, Christoph Nowak, Takayoshi Ohkubo, Michelle J. Pena, Kevan R. Polkinghorne, Toshimi Sairenchi, Elke Schaeffner, Markus P. Schneider, Varda Shalev, Michael G. Shlipak, Marit D. Solbu, Nikita Stempniewicz, James Tollitt, Jose M. Valdivielso, Joep van der Leeuw, Angela Yee Moon Wang, Chi Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Jannick A. N. Dorresteijn, Emanuele Di Angelantonio, Frank L. J. Visseren, Lisa Pennells, Josef Coresh
Summary: This study developed an "Add-on" method to incorporate chronic kidney disease (CKD) measures into cardiovascular disease (CVD) risk prediction algorithms, which improved the predictive accuracy. This approach will assist clinicians and patients in more precise risk assessment and personalized preventive therapies for CKD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Editorial Material
Transplantation
Alberto Ortiz, Christoph Wanner, Ron Gansevoort
Summary: The European Society of Cardiology 2021 guideline on cardiovascular disease prevention has significant implications for CV risk screening and kidney health. The guideline proposes specific strategies for individuals with established CVD, diabetes, hypercholesterolemia, or CKD. This includes the assessment of albuminuria as an entry-level step in CVD risk assessment, which could change current clinical practice. Further research is needed to determine the optimal method for CV risk assessment, including CKD assessment in the general population.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Ron T. Gansevoort, Hans-Joachim Anders, Mario Cozzolino, Danilo Fliser, Denis Fouque, Alberto Ortiz, Maria Jose Soler, Christoph Wanner
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Immunology
Javier Donate-Correa, Emiliano Matos-Perdomo, Ainhoa Gonzalez-Luis, Alberto Martin-Olivera, Alberto Ortiz, Carmen Mora-Fernandez, Juan F. Navarro-Gonzalez
Summary: Kidney transplant recipients have better survival rates and improved quality of life. The KL gene encodes the antiaging and kidney-protective protein Klotho, which is highly expressed in kidney tubular cells. Klotho expression decreases during kidney injury or disease, and its deficiency is associated with accelerated aging. This review explores the relationship between Klotho and kidney transplantation, including its potential as a biomarker for graft function and outcomes, and its impact on kidney protection in transplantation.
Review
Medicine, Research & Experimental
Raul Fernandez-Prado, Priscila Villalvazo, Alejandro Avello, Marina Gonzalez-de-Rivera, Michelle Aguirre, Carlos G. Carrasco-Munoz, Beatriz Fernandez-Fernandez, Catalina Martin-Cleary, Sol Carriazo, Maria Dolores Sanchez-Nino, Maria Vanessa Perez-Gomez, Alberto Ortiz
Summary: Metabolic acidosis is common in CKD and has various negative effects. SZC, a potassium binder, has been shown to increase serum bicarbonate and decrease serum urea, potentially providing benefits in CKD management. The mechanism of action appears to involve SZC binding to ammonium ions in the gut, preventing their absorption and promoting the excretion of H+ ions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Transplantation
Borja Quiroga, Maria Jose Soler, Alberto Ortiz, Carlos Jesus Jarava Mantecon, Virginia Olinda Gomes Perez, Antoni Bordils, Jose Lacueva, Antonio Jose Marin Franco, Pablo Delgado Conde, Patricia Munoz Ramos, Carmen Calderon Gonzalez, Juan Manuel Cazorla Lopez, Jinny Sanchez-Rodriguez, Ana Sanchez Horrillo, Tania Raquel Monzon Vazquez, Alba Leyva, Jose Rojas, Ron T. Gansevoort, Patricia de Sequera
Summary: This study evaluated the humoral response and effectiveness of the fourth dose of COVID-19 vaccines in chronic kidney disease (CKD) patients. The fourth dose increased antibody levels in CKD patients undergoing hemodialysis and non-dialysis CKD patients, and seroconverted previously negative patients. However, CKD patients with lower pre-booster antibody titres or kidney transplant recipients derived the least benefit in terms of antibody levels.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Letter
Medicine, General & Internal
Soln Carriazo, Alberto Ortiz, Beatriz Fernandez-Fernandez
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Flavia Trionfetti, Vanessa Marchant, Guadalupe. T. T. Gonzalez-Mateo, Edyta Kawka, Laura Marquez-Exposito, Alberto Ortiz, Manuel Lopez-Cabrera, Marta Ruiz-Ortega, Raffaele Strippoli
Summary: The global incidence of chronic kidney disease (CKD) is increasing, leading to a significant number of CKD patients developing end-stage renal disease (ESRD) and requiring kidney replacement therapies (KRT). Peritoneal dialysis (PD) is a convenient home therapy for KRT, but it can lead to damage of the peritoneal membrane (PM) due to the exposure to PD fluids containing high concentrations of glucose or other osmotic agents. This damage involves inflammation and fibrosis, which can be worsened by peritonitis episodes. In this article, we review the role of immune cells in PM damage during KRT and infections, as well as the anti-inflammatory properties of current clinical treatments for CKD patients in KRT and their potential effect on preserving PM integrity. Additionally, we discuss the implications of COVID-19 in CKD and KRT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Urology & Nephrology
Ana B. Sanz, Maria Dolores Sanchez-Nino, Adrian M. Ramos, Alberto Ortiz
Summary: Disorders of cell number resulting from imbalanced cell death and proliferation contribute to kidney disease. Different modes of regulated cell death, such as apoptosis and necrosis, play central roles in the pathogenesis of kidney diseases. Necroptosis, pyroptosis, and ferroptosis can directly cause kidney injury or stimulate immune cells and inflammatory responses. Understanding these regulated pathways of cell death is important for therapeutic targeting and further research.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Transplantation
Pantelis A. Sarafidis, Marieta Theodorakopoulou, Alberto Ortiz, Beatriz Fernandez-Fernandez, Ionut Nistor, Roland Schmieder, Mustafa Arici, Athanasios Saratzis, Patricia van der Niepen, Jean-Michel Halimi, Reinhold Kreutz, Andrzej Januszewicz, Alexandre Persu, Mario Cozzolino
Summary: Atherosclerotic renovascular disease (ARVD) is a common type of renal artery stenosis with a high risk for future cardiovascular and renal events. The evidence regarding the management of ARVD is conflicting, but some observational studies suggest potential cardiorenal benefits of percutaneous transluminal renal artery angioplasty (PTRA) in high-risk ARVD phenotypes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Letter
Medicine, General & Internal
Alberto Ortiz
Article
Medicine, General & Internal
Teresa Vazquez-Sanchez, Maria Dolores Sanchez-Nino, Pedro Ruiz-Esteban, Veronica Lopez, Myriam Leon, Abelardo Caballero, Juan Francisco Ruiz-Escalera, Alberto Ortiz, Armando Torres, Mariano Rodriguez, Domingo Hernandez
Summary: This study investigated the changes in serum klotho (s-Kl) and FGF-23 levels during the first two years post-kidney transplantation (KT), considering cold ischemia time (CIT), glomerular filtration rate (GFR), and graft subclinical inflammation (SCI). The study included 147 patients and found that s-Kl levels were low at 3 months post-KT for all patients. Patients with CIT < 14 h showed a significant increase in s-Kl at 24 months, while patients with CIT ≥ 14 h had a decrease in s-Kl at 3 months and lower levels at 24 months. GFR > 40 was associated with a lesser decrease in s-Kl at 3 months. FGF-23 levels decreased significantly at 3 and 12 months in both GFR groups. The study highlights the impact of CIT, GFR, and SCI on s-Kl levels post-KT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Serafi Cambray, Marcelino Bermudez-Lopez, Alicia Garcia-Carrasco, Jose M. Valdivielso, NEFRONA investigators
Summary: This study investigated the role of single nucleotide polymorphisms (SNPs) of the matrix gamma-carboxy glutamic acid protein (MGP) gene on atherosclerosis progression and cardiovascular events (CVE) in CKD patients. The results showed that the rs1800802 polymorphism of MGP is associated with increased risk of plaque progression and CVE in CKD patients.
CLINICAL KIDNEY JOURNAL
(2023)