Connective tissue growth factor induces renal fibrosis via epidermal growth factor receptor activation

Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis

(2017) Jessica M. Overstreet et al.   FASEB JOURNAL

Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis

(2017) Hiroshi Kinashi et al.   KIDNEY INTERNATIONAL

The C-Terminal Module IV of Connective Tissue Growth Factor, Through EGFR/Nox1 Signaling, Activates the NF-κB Pathway and Proinflammatory Factors in Vascular Smooth Muscle Cells

(2015) Raúl R. Rodrigues-Diez et al.   ANTIOXIDANTS & REDOX SIGNALING

Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions

(2015) Satoshi Kubota et al.   CLINICAL SCIENCE

CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload

(2015) Magda S.C. Fontes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition

(2015) Xiaoping Zhu et al.   Oncotarget

Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury

(2014) G. Canaud et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Nuclear Translocation of hARD1 Contributes to Proper Cell Cycle Progression

(2014) Ji-Hyeon Park et al.   PLoS One

The role of ERK and JNK signaling in connective tissue growth factor induced extracellular matrix protein production and scar formation

(2013) Xiaolong Hu et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

TrkB is responsible for EMT transition in malignant pleural effusions derived cultures from adenocarcinoma of the lung

(2013) Alberto Ricci* et al.   CELL CYCLE

The C-terminal module IV of connective tissue growth factor is a novel immune modulator of the Th17 response

(2013) Raquel Rodrigues-Díez et al.   LABORATORY INVESTIGATION

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Connective tissue growth factor is a new ligand of epidermal growth factor receptor

(2013) Sandra Rayego-Mateos et al.   Journal of Molecular Cell Biology

Hyperglycemia Causes Renal Cell Damage via CCN2-Induced Activation of the TrkA Receptor: Implications for Diabetic Nephropathy

(2012) M. Fragiadaki et al.   DIABETES

The role of the Janus kinase family/signal transducer and activator of transcription signaling pathway in fibrotic renal disease

(2012) Futoshi Matsui et al.   JOURNAL OF SURGICAL RESEARCH

Genetic or Pharmacologic Blockade of EGFR Inhibits Renal Fibrosis

(2012) N. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TWEAK (tumor necrosis factor–like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation

(2012) María Concepción Izquierdo et al.   KIDNEY INTERNATIONAL

Epidermal growth factor: a new therapeutic target in glomerular disease

(2012) M. Flamant et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells

(2012) C.-Y. Sun et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Heparin-Binding EGF-Like Growth Factor Induces Heart Interstitial Fibrosis via an Akt/mTor/p70s6k Pathway

(2012) Hong Lian et al.   PLoS One

Crosstalks between the receptors tyrosine kinase EGFR and TrkA and the GPCR, FPR, in human monocytes are essential for receptors-mediated cell activation

(2010) Nabil El Zein et al.   CELLULAR SIGNALLING

Mechanisms of Tubulointerstitial Fibrosis

(2010) M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy

(2010) Maoyin Pang et al.   KIDNEY INTERNATIONAL

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes

(2010) Xiaoyu Wang et al.   Journal of Cell Communication and Signaling

CTGF Promotes Inflammatory Cell Infiltration of the Renal Interstitium by Activating NF- B

(2009) E. Sanchez-Lopez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2009) Y. Liu   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Connective Tissue Growth Factor-(CTGF, CCN2) – A Marker, Mediator and Therapeutic Target for Renal Fibrosis

(2009) Mysore K. Phanish et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo

(2009) David R. Brigstock   Journal of Cell Communication and Signaling

Connective tissue growth factor: Structure–function relationships of a mosaic, multifunctional protein

(2008) Patricia De Winter et al.   GROWTH FACTORS

Pharmacological Modulation of Epithelial Mesenchymal Transition Caused by Angiotensin II. Role of ROCK and MAPK Pathways

(2008) Raquel Rodrigues-Díez et al.   PHARMACEUTICAL RESEARCH

Connective tissue growth factor stimulates renal cortical myofibroblast-like cell proliferation and matrix protein production

(2008) Xuxia Gao et al.   WOUND REPAIR AND REGENERATION