Article
Biochemistry & Molecular Biology
Marian Christoph, Christian Pfluecke, Matthias Mensch, Antje Augstein, Stefanie Jellinghaus, Georg Ende, Johannes Mierke, Kristin Franke, Ben Wielockx, Karim Ibrahim, David M. Poitz
Summary: This study aimed to investigate the role of myeloid PHD2 in atherosclerosis and neointima formation. The results showed that myeloid Hif-1 alpha is involved in neointima hyperplasia, and there is a correlation between inflammatory reaction and collagen content with neointima formation.
MOLECULAR IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ankita Solanki, Shreya R. Savla, Maheshkumar R. Borkar, Lokesh K. Bhatt
Summary: Sulfamethizole significantly limits poloxamer 407-induced atherosclerotic neointima formation in C57BL/6 mice via mTOR inhibition. This study demonstrates that sulfamethizole reduces plasma lipid levels, attenuates atherosclerotic lesions, and interacts with mTOR protein.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Cell Biology
Wanbing He, Jieping Huang, Yang Liu, Changming Xie, Kun Zhang, Xinhong Zhu, Jie Chen, Hui Huang
Summary: The study revealed that deletion of sEH can inhibit vascular calcification in CKD by preserving the expression of Sirt3, which plays a crucial role in suppressing the calcification of vascular smooth muscle cells. The findings suggest that sEH inhibition could be a promising target for preventing vascular calcification.
CELL DEATH & DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Andreas Edsfeldt, Maarten Swart, Pratibha Singh, Lea Dib, Jiangming Sun, Jennifer E. Cole, Inhye Park, Dania Al-Sharify, Ana Persson, Mihaela Nitulescu, Patricia Das Neves Borges, Christina Kassiteridi, Michael E. Goddard, Regent Lee, Petr Volkov, Marju Orho-Melander, Lars Maegdefessel, Jan Nilsson, Irina Udalova, Isabel Goncalves, Claudia Monaco
Summary: The study found that IRF5 is associated with plaque vulnerability and symptoms in human carotid endarterectomies. In a murine model of inducible carotid artery plaque rupture, IRF5 drives plaque rupture. IRF5 modulates macrophage phenotype and colocalizes with CD11c(+) macrophages at the plaque shoulder.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Xiu Liu, Jia-Wei Guo, Xiao-Chun Lin, Yong-Hua Tuo, Wan-Li Peng, Su-Yue He, Zhao-Qiang Li, Yan-Chen Ye, Jie Yu, Fei-Ran Zhang, Ming-Ming Ma, Jin-Yan Shang, Xiao-Fei Lv, An-Dong Zhou, Ying Ouyang, Cheng Wang, Rui-Ping Pang, Jian-Xin Sun, Jing-Song Ou, Jia-Guo Zhou, Si-Jia Liang
Summary: Macrophage NFATc3 up-regulates miR-204 to reduce SR-A and CD36 levels, thereby preventing foam cell formation and atherosclerosis, suggesting that the NFATc3/miR-204 axis may be a potential therapeutic target against atherosclerosis.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Xiu Liu, Jia-Wei Guo, Xiao-Chun Lin, Yong-Hua Tuo, Wan-Li Peng, Su-Yue He, Zhao-Qiang Li, Yan-Chen Ye, Jie Yu, Fei-Ran Zhang, Ming-Ming Ma, Jin-Yan Shang, Xiao-Fei Lv, An-Dong Zhou, Ying Ouyang, Cheng Wang, Rui-Ping Pang, Jian-Xin Sun, Jing-Song Ou, Jia-Guo Zhou, Si-Jia Liang
Summary: The study showed that macrophage NFATc3 up-regulates miR-204 to reduce SR-A and CD36 levels, thereby preventing foam cell formation and atherosclerosis, indicating a potential therapeutic target against atherosclerosis.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Weiwei An, Le A. Luong, Neil P. Bowden, Mei Yang, Wei Wu, Xinmiao Zhou, Chenxin Liu, Kaiyuan Niu, Jun Luo, Cheng Zhang, Xiaolei Sun, Robin Poston, Li Zhang, Paul C. Evans, Qingzhong Xiao
Summary: Cezanne plays a key role in VSMC proliferation and migration in pathological arterial remodelling, and it is highly expressed in human atherosclerotic lesions.
CARDIOVASCULAR RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Pengyu Wang, Manman Li, Tielei Gao, Jiaying Fan, Dengfeng Zhang, Ying Zhao, Yajie Zhao, Yuqin Wang, Tianwei Guo, Xi Gao, Yujun Liu, Yang Gao, Xue Guan, Xinyong Sun, Jiyi Zhao, Hong Li, Liming Yang
Summary: Electrical stimulation (ES) is a safe and effective clinical rehabilitation procedure for atherosclerosis (AS). In this study, ES was applied to the abdominal aorta of high-fat-fed Apolipoprotein E (ApoE(-/-)) mice to observe the effects on atherosclerotic plaques. Results showed that ES reduced plaque growth and increased autophagy-related gene activity. ES also restored cholesterol efflux and alleviated atherosclerotic lesion formation through the Sirt1/Atg5 pathway.
Article
Biochemistry & Molecular Biology
Sanuja Fernando, Thalia Salagaras, Nisha Schwarz, Lauren Sandeman, Joanne T. M. Tan, Jianling Xie, Jonar Zareh, Kirk Jensen, Anna Williamson, Catherine Dimasi, Pich Chhay, Deborah Toledo-Flores, Aaron Long, Jim Manavis, Michael Worthington, Robert Fitridge, Belinda A. Di Bartolo, Christina A. Bursill, Stephen J. Nicholls, Christopher G. Proud, Peter J. Psaltis
Summary: This study reveals a new role for eukaryotic elongation factor 2 kinase (eEF2K) in regulating foam cell formation and CD36 expression in macrophages. Disabling eEF2K reduces atherosclerotic plaque size in mice but does not decrease lipid content.
Article
Pharmacology & Pharmacy
Sindhu C. Pillai, Ankita Borah, Minh Nguyen Tuyet Le, Hiroaki Kawano, Kouichi Hasegawa, D. Sakthi Kumar
Summary: Nutraceuticals, such as curcumin, have shown potential benefits in treating and preventing cardiovascular diseases, including atherosclerosis. The development of nano-drug delivery systems, like Cur-Bio PLGA NPs, offers a promising approach to target atherosclerotic plaque sites effectively. The combination of curcumin and Bioperine in this system demonstrated enhanced reduction in cholesterol content and downregulation of inflammatory pathways associated with atherosclerosis, highlighting the importance of natural-based compounds in therapeutic interventions.
Article
Biochemistry & Molecular Biology
Michishige Terasaki, Keita Shibata, Yusaku Mori, Tomomi Saito, Takanori Matsui, Makoto Ohara, Tomoyasu Fukui, Keiji Hasumi, Yuichiro Higashimoto, Koji Nobe, Sho-ichi Yamagishi
Summary: SMTP-44D inhibits the formation of atherosclerotic plaques by blocking the AGEs-RAGE pathway and reduces macrophage infiltration and AGEs accumulation in the aortic roots. It also reduces foam cell formation in macrophages by suppressing the Cdk5-CD36 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yaw-Wen Hsu, Fu-Fei Hsu, Ming-Tsai Chiang, Dong-Lin Tsai, Fu-An Li, Takashi Angata, Paul R. Crocker, Lee-Young Chau
Summary: Siglec-E deficiency accelerates the development of atherosclerosis by promoting foam cell formation, potentially through its interaction with CD36 to inhibit foam cell formation. The research findings support the protective role of Siglec-E in atherosclerosis.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Jintao Feng, Wei Jiang, Xiaofang Cheng, Benkun Zou, Alan W. Varley, Ting Liu, Guojun Qian, Wenjiao Zeng, Jianguo Tang, Qiang Zhao, Yiwei Chu, Yuanyuan Wei, Xiaobo Li, Robert S. Munford, Mingfang Lu
Summary: Research showed that acyloxyacyl hydrolase (AOAH) can prevent foam cell formation in mice, reduce cholesterol accumulation, and inflammation. Aoah(-/-) mice developed more arterial foam cells after being fed a high fat, high cholesterol diet and receiving small doses of LPSs.
Article
Multidisciplinary Sciences
Xinbo Zhang, Jeffrey G. McDonald, Binod Aryal, Alberto Canfran-Duque, Emily L. Goldberg, Elisa Araldi, Wen Ding, Yuhua Fan, Bonne M. Thompson, Abhishek K. Singh, Qian Li, George Tellides, Jose Ordovas-Montanes, Rolando Garcia Milian, Vishwa Deep Dixit, Elina Ikonen, Yajaira Suarez, Carlos Fernandez-Hernando
Summary: Desmosterol, the most abundant cholesterol biosynthetic intermediate in human coronary artery lesions, plays an essential role during atherogenesis by integrating with macrophage cholesterol metabolism and inflammatory activation to dampen inflammation and protect from disease progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Minghua Zhang, Jing Liu, Rong Gao, Yazhuo Hu, Li Lu, Chuanbin Liu, Lunna Ai, Jingkun Pan, Lei Tian, Jiao Fan
Summary: IL-36γ plays a role in regulating inflammatory responses and lipoprotein metabolism in macrophages, promoting foam cell formation and uptake of oxidized low-density lipoproteins, and thereby advancing atherosclerosis progression.
Article
Oncology
Said A. Khelwatty, Sharadah Essapen, Alan M. Seddon, Zhen Fan, Helmout Modjtahedi
BRITISH JOURNAL OF CANCER
(2015)
Article
Immunology
Samer Bazzi, Helmout Modjtahedi, Satvinder Mudan, Charles Akle, Georges M. Bahr
Article
Oncology
Nikolaos Ioanou, Alan M. Sedon, Angus Dalgleish, David Mackintosh, Flavio Solca, Helmout Modjtahedi
INTERNATIONAL JOURNAL OF ONCOLOGY
(2016)
Article
Oncology
Soozana Puvanenthiran, Sharadah Essapen, Alan M. Seddon, Helmout Modjtahedi
INTERNATIONAL JOURNAL OF ONCOLOGY
(2016)
Article
Nutrition & Dietetics
Andrius Jaksevicius, Mark Carew, Calli Mistry, Helmout Modjtahedi, Elizabeth I. Opara
Letter
Oncology
Helmout Modjtahedi, Suzanne Eccles
CLINICAL CANCER RESEARCH
(2014)
Article
Immunology
Mohsen Navari, Mehrak Zare, Masoud Javanmardi, Majid Asadi-Ghalehni, Helmout Modjtahedi, Mohammad Javed Rasaee
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2014)
Article
Food Science & Technology
Elena Polycarpou, Lisiane B. Meira, Simon Carrington, Elizabeth Tyrrell, Helmout Modjtahedi, Mark A. Carew
MOLECULAR NUTRITION & FOOD RESEARCH
(2013)
Review
Pharmacology & Pharmacy
Helmout Modjtahedi, Byoung Chul Cho, Martin C. Michel, Flavio Solca
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2014)
Article
Multidisciplinary Sciences
Said Abdullah Khelwatty, Sharadah Essapen, Izhar Bagwan, Margaret Green, Alan Michael Seddon, Helmout Modjtahedi
Article
Multidisciplinary Sciences
Aryan Stanley, G. Hossein Ashrafi, Alan M. Seddon, Helmout Modjtahedi
SCIENTIFIC REPORTS
(2017)
Article
Biotechnology & Applied Microbiology
Masoud Javanmardi, Mohammad Javad Rasaee, Helmout Modjtahedi, Majid Asadi-Ghalehni, Mohammad Ghaem Maghami
IRANIAN JOURNAL OF BIOTECHNOLOGY
(2014)
Article
Oncology
Said A. Khelwatty, Soozana Puvanenthiran, Sharadah Essapen, Izhar Bagwan, Alan M. Seddon, Helmout Modjtahedi
Summary: The study revealed that high levels of HER2 expression were found in CRC patients treated with cetuximab, which was associated with shorter progression free survival. The results support the emergence of HER2 as a therapeutic target in mCRC patients.
Review
Oncology
Gustavo A. Arias-Pinilla, Helmout Modjtahedi
Summary: Pancreatic cancer is a highly aggressive type of cancer with poor response to current treatments, leading to its high mortality rate worldwide. Monoclonal antibody technology shows promise in discovering novel therapeutic targets and developing more effective treatment options for pancreatic cancer patients, although no mAbs have been approved for this specific cancer type yet. Further research and development in this field may lead to the approval and widespread use of antibody-based agents for the treatment of pancreatic cancer in the future.
Article
Biochemistry & Molecular Biology
Samer Bazzi, Emale El-Darzi, Tina McDowell, Helmout Modjtahedi, Satvinder Mudan, Marcel Achkar, Charles Akle, Humam Kadara, Georges M. Bahr
Summary: The study analyzed the cytokine and chemokines release patterns of human macrophages exposed to different stimuli, revealing distinct differences in cytokine release patterns between macrophages in different activation states.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)