Fucoidan Induces ROS-Dependent Apoptosis in 5637 Human Bladder Cancer Cells by Downregulating Telomerase Activity via Inactivation of the PI3K/Akt Signaling Pathway

Reactivation of telomerase in cancer

(2016) Semih Can Akincilar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

PI3K inhibitors as new cancer therapeutics: implications for clinical trial design

(2016) Cristian Massacesi et al.   OncoTargets and Therapy

NAC selectively inhibit cancer telomerase activity: A higher redox homeostasis threshold exists in cancer cells

(2016) Pengying Li et al.   Redox Biology

Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease

(2015) Seon Ae Eom et al.   BMB Reports

Restoration of mitochondria function as a target for cancer therapy

(2015) Tariq A. Bhat et al.   DRUG DISCOVERY TODAY

Cordyceptin induces apoptosis through repressing hTERT expression and inducing extranuclear export of hTERT

(2015) Kyung-Jun Jang et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Akt-mediated phosphorylation increases the binding affinity of hTERT for importin   to promote nuclear translocation

(2015) S. A. Jeong et al.   JOURNAL OF CELL SCIENCE

Therapies from Fucoidan: An Update

(2015) Janet Fitton et al.   Marine Drugs

Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice

(2015) Tse-Hung Huang et al.   Marine Drugs

Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia

(2015) Meng-Chuan Chen et al.   Marine Drugs

Role of diallyl disulfide-mediated cleavage of c-Myc and Sp-1 in the regulation of telomerase activity in human lymphoma cell line U937

(2015) Pritha Dasgupta et al.   NUTRITION

Inhibitory activities ofPerilla frutescensbritton leaf extract against the growth, migration, and adhesion of human cancer cells

(2015) Youngeun Kwak et al.   Nutrition Research and Practice

Targeting the genetic alterations of the PI3K–AKT–mTOR pathway: Its potential use in the treatment of bladder cancers

(2015) Nadine Houédé et al.   PHARMACOLOGY & THERAPEUTICS

Effects of Mitochondrial Translocation of Telomerase on Drug Resistance in Hepatocellular Carcinoma Cells

(2015) Jing Yan et al.   Journal of Cancer

Telomerase Modulation in Therapeutic Approach

(2014) Aleksandra Romaniuk et al.   CURRENT PHARMACEUTICAL DESIGN

Paradoxical action of reactive oxygen species in creation and therapy of cancer

(2014) Sina Kardeh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fucoidan Inhibits the Proliferation of Human Urinary Bladder Cancer T24 Cells by Blocking Cell Cycle Progression and Inducing Apoptosis

(2014) Hye Park et al.   MOLECULES

Anti-Metastasis Effect of Fucoidan from Undaria pinnatifida Sporophylls in Mouse Hepatocarcinoma Hca-F Cells

(2014) Peisheng Wang et al.   PLoS One

Telomerase promoter mutations in cancer: an emerging molecular biomarker?

(2014) João Vinagre et al.   VIRCHOWS ARCHIV

Mitochondria-mediated apoptosis in mammals

(2014) Shunbin Xiong et al.   Protein & Cell

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

(2013) Krishnendu Sinha et al.   ARCHIVES OF TOXICOLOGY

Telomere shortening in human diseases

(2013) Chiou Mee Kong et al.   FEBS Journal

Fucoidan Derived from Undaria pinnatifida Induces Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells via the ROS-Mediated Mitochondrial Pathway

(2013) Lili Yang et al.   Marine Drugs

Fucoidan Extract Enhances the Anti-Cancer Activity of Chemotherapeutic Agents in MDA-MB-231 and MCF-7 Breast Cancer Cells

(2013) Zhongyuan Zhang et al.   Marine Drugs

Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family

(2013) Hyun Park et al.   Marine Drugs

The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells

(2013) Hye-Jin Boo et al.   Marine Drugs

Inhibition of Telomerase Activity by Oleanane Triterpenoid CDDO-Me in Pancreatic Cancer Cells is ROS-Dependent

(2013) Dorrah Deeb et al.   MOLECULES

Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis

(2013) Chatchawan Singhapol et al.   PLoS One

The MAPK Pathway Signals Telomerase Modulation in Response to Isothiocyanate-Induced DNA Damage of Human Liver Cancer Cells

(2013) Evelyn Lamy et al.   PLoS One

Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases

(2013) Hsi-Lung Hsieh et al.   Biomed Research International

Targeting the PI3K signaling pathway in cancer therapy

(2012) Chandra Bartholomeusz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Apigenin decreases cell viability and telomerase activity in human leukemia cell lines

(2012) R.G.P.T. Jayasooriya et al.   FOOD AND CHEMICAL TOXICOLOGY

Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation

(2012) J. Chung et al.   JOURNAL OF CELL SCIENCE

Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo

(2012) Meilan Xue et al.   PLoS One

Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells

(2011) Hye Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Fucoidan from Undaria pinnatifida Induces Apoptosis in A549 Human Lung Carcinoma Cells

(2011) Hye-Jin Boo et al.   PHYTOTHERAPY RESEARCH

Fucoidan Extract Induces Apoptosis in MCF-7 Cells via a Mechanism Involving the ROS-Dependent JNK Activation and Mitochondria-Mediated Pathways

(2011) Zhongyuan Zhang et al.   PLoS One

Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway

(2010) Dong-Oh Moon et al.   CANCER LETTERS

hTERT Overexpression Alleviates Intracellular ROS Production, Improves Mitochondrial Function, and Inhibits ROS-Mediated Apoptosis in Cancer Cells

(2010) I. R. Indran et al.   CANCER RESEARCH

Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway

(2010) Christina Barbara Ching et al.   LABORATORY INVESTIGATION

N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells

(2010) I-Lun Hsin et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Apoptosis Inducing Activity of Fucoidan in HCT-15 Colon Carcinoma Cells

(2009) Jae-Hee Hyun et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

PPARγ ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells

(2009) Cristina Toaldo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structure, biological activity, and enzymatic transformation of fucoidans from the brown seaweeds

(2008) Mikhail Kusaykin et al.   Biotechnology Journal

Understanding and exploitinghTERTpromoter regulation for diagnosis and treatment of human cancers

(2008) Satoru Kyo et al.   CANCER SCIENCE

Akt as a therapeutic target in cancer

(2008) Linda S Steelman et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Bcl-2 family proteins: The sentinels of the mitochondrial apoptosis pathway

(2008) W. Wei-Lynn Wong et al.   IUBMB LIFE