Mitochondrial apoptosis is induced by Alkoxy phenyl-1-propanone derivatives through PP2A-mediated dephosphorylation of Bad and Foxo3A in CLL

Frontline Therapy of CLL: Evolving Treatment Paradigm

(2018) Craig S. Boddy et al.   Current Hematologic Malignancy Reports

Bax, Bak and beyond - mitochondrial performance in apoptosis

(2017) Aida Peña-Blanco et al.   FEBS Journal

Targeted activation of the SHP-1/PP2A signaling axis elicits apoptosis of chronic lymphocytic leukemia cells

(2017) Elena Tibaldi et al.   HAEMATOLOGICA

Bruton’s tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia

(2017) J Deng et al.   LEUKEMIA

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

(2017) Avi Ashkenazi et al.   NATURE REVIEWS DRUG DISCOVERY

Apoptotic foci at mitochondria: in and around Bax pores

(2017) Begoña Ugarte-Uribe et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Targeted activation of the SHP-1/PP2A signaling axis elicits apoptosis of chronic lymphocytic leukemia cells

(2017) Elena Tibaldi et al.   HAEMATOLOGICA

Chronic lymphocytic leukaemia

(2017) Thomas J. Kipps et al.   Nature Reviews Disease Primers

Venetoclax: A novel B-cell lymphoma-2 inhibitor for chronic lymphocytic leukemia and other hematologic malignancies

(2017) Jacqueline L Olin et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

B cell receptor inhibition as a target for CLL therapy

(2016) Deepa Jeyakumar et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199

(2016) K. Bojarczuk et al.   BLOOD

Combination of Targeted Drugs to Control Chronic Lymphocytic Leukemia

(2016) Paula Cramer et al.   CANCER JOURNAL

Bcl-2 proteins in development, health, and disease of the hematopoietic system

(2016) Matthias Kollek et al.   FEBS Journal

Second-generation inhibitors of Bruton tyrosine kinase

(2016) Jingjing Wu et al.   Journal of Hematology & Oncology

Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia

(2016) John C. Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeted Therapy of CLL

(2016) Othman Al-Sawaf et al.   Oncology Research and Treatment

Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: A role for mitoBKCa channels

(2015) Patrycja Kaczara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Lyn sustains oncogenic signaling in chronic lymphocytic leukemia by strengthening SET-mediated inhibition of PP2A

(2015) F. Zonta et al.   BLOOD

BCL-2 Antagonism to Target the Intrinsic Mitochondrial Pathway of Apoptosis

(2015) C. J. Gibson et al.   CLINICAL CANCER RESEARCH

The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL

(2015) K Balakrishnan et al.   LEUKEMIA

Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia

(2015) Jan A. Burger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Bim in Health and Disease

(2015) Ronit Vogt Sionov et al.   Oncotarget

Regulation of PP2A by Sphingolipid Metabolism and Signaling

(2015) Joshua Oaks et al.   Frontiers in Oncology

FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis

(2014) Jiao Wang et al.   APOPTOSIS

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Idelalisib and Rituximab in Relapsed Chronic Lymphocytic Leukemia

(2014) Richard R. Furman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lyn-mediated procaspase 8 dimerization blocks apoptotic signaling in B-cell chronic lymphocytic leukemia

(2013) F. Zonta et al.   BLOOD

Hsp90, an unlikely ally in the war on cancer

(2013) Jared J. Barrott et al.   FEBS Journal

Apoptosis Regulation at the Mitochondrial Outer Membrane

(2013) Laura A. Gillies et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MBNL1 42 and MBNL1 43 gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinases

(2013) A Botta et al.   Cell Death & Disease

A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia

(2012) L-N Zhang et al.   CANCER GENE THERAPY

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

BH3-only proteins in apoptosis at a glance

(2012) L. Happo et al.   JOURNAL OF CELL SCIENCE

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(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target

(2011) D. J. Christensen et al.   BLOOD

B-cell receptor signaling in chronic lymphocytic leukemia

(2011) F. K. Stevenson et al.   BLOOD

Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt

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BH3-only proteins: Orchestrators of apoptosis

(2010) Aisha Shamas-Din et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hsp90: A Drug Target?

(2010) Jeffrey M. Holzbeierlein et al.   Current Oncology Reports

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(2009) Dirk Brenner et al.   CURRENT OPINION IN CELL BIOLOGY

Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition

(2009) J. Zhuang et al.   HAEMATOLOGICA

BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3

(2008) A. Nordigarden et al.   BLOOD

Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia

(2008) L. Trentin et al.   BLOOD