Lyn-mediated procaspase 8 dimerization blocks apoptotic signaling in B-cell chronic lymphocytic leukemia

Regulation of Neuronal Cell Death by c-Abl-Hippo/MST2 Signaling Pathway

(2012) Weizhe Liu et al.   PLoS One

Caspase-8 and Bid: Caught in the act between death receptors and mitochondria

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Proliferative versus apoptotic functions of caspase-8

(2011) Bram J. van Raam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765

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LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection

(2011) Yonghao Cao et al.   EMBO JOURNAL

The c-Abl-MST1 Signaling Pathway Mediates Oxidative Stress-Induced Neuronal Cell Death

(2011) L. Xiao et al.   JOURNAL OF NEUROSCIENCE

IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells

(2011) M Coscia et al.   LEUKEMIA

Lyn-mediated SHP-1 recruitment to CD5 contributes to resistance to apoptosis of B-cell chronic lymphocytic leukemia cells

(2011) E Tibaldi et al.   LEUKEMIA

PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia

(2011) Alexander Brobeil et al.   LEUKEMIA RESEARCH

Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL

(2010) E. Rosati et al.   BLOOD

Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion

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From procaspase-8 to caspase-8: Revisiting structural functions of caspase-8

(2010) Yang Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The microenvironment in mature B-cell malignancies: a target for new treatment strategies

(2009) J. A. Burger et al.   BLOOD

Critical Role for Caspase-8 in Epidermal Growth Factor Signaling

(2009) D. Finlay et al.   CANCER RESEARCH

Studies of the molecular mechanism of caspase-8 activation by solution NMR

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Non-apoptotic functions of caspase-8

(2008) Jonathan Maelfait et al.   BIOCHEMICAL PHARMACOLOGY

c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches

(2008) D. Y. H. Hallaert et al.   BLOOD

Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia

(2008) L. Trentin et al.   BLOOD

The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes

(2008) A. Veldurthy et al.   BLOOD

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

(2008) M. Hallek et al.   BLOOD

Caspase-8 in cancer biology and therapy

(2008) Simone Fulda   CANCER LETTERS

Caspase-8: Fly or Die

(2008) S. M. Frisch   CANCER RESEARCH

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

(2008) S Gobessi et al.   LEUKEMIA