Hsp90, an unlikely ally in the war on cancer

An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC).

(2017) K. Wong et al.   JOURNAL OF CLINICAL ONCOLOGY

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

(2015) Mehdi Mollapour et al.   Oncotarget

A highly selective Hsp90 affinity chromatography resin with a cleavable linker

(2012) Philip F. Hughes et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hsp90 Globally Targets Paused RNA Polymerase to Regulate Gene Expression in Response to Environmental Stimuli

(2012) Ritwick Sawarkar et al.   CELL

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

The expanding proteome of the molecular chaperone HSP90

(2012) Rahul S. Samant et al.   CELL CYCLE

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models

(2012) David A. Proia et al.   INVESTIGATIONAL NEW DRUGS

Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci

(2012) Maria Quanz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

(2012) Chengkai Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting KRAS-Mutant Non-Small Cell Lung Cancer with the Hsp90 Inhibitor Ganetespib

(2012) J. Acquaviva et al.   MOLECULAR CANCER THERAPEUTICS

Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine

(2012) Wanping Xu et al.   MOLECULAR CELL

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dynamics of targeted cancer therapy

(2012) Ivana Bozic et al.   TRENDS IN MOLECULAR MEDICINE

Circumventing Cancer Drug Resistance in the Era of Personalized Medicine

(2012) Levi A. Garraway et al.   Cancer Discovery

Secreted heat shock protein-90 (Hsp90) in wound healing and cancer

(2011) Wei Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

(2011) Mehdi Mollapour et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Extracellular HSP90: Conquering the cell surface

(2011) Katerina Sidera et al.   CELL CYCLE

Antitumor Activity of SNX-2112, a Synthetic Heat Shock Protein-90 Inhibitor, in MET-Amplified Tumor Cells with or without Resistance to Selective MET Inhibition

(2011) T. Bachleitner-Hofmann et al.   CLINICAL CANCER RESEARCH

An Evaluation of Single Nucleotide Polymorphisms in the Human Heat Shock Protein 90 kDa Alpha and Beta Isoforms

(2011) Jonathan D. Urban et al.   Drug Metabolism and Pharmacokinetics

A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α–positive tumors

(2011) Divya Sahu et al.   MOLECULAR BIOLOGY OF THE CELL

Ganetespib, a Unique Triazolone-Containing Hsp90 Inhibitor, Exhibits Potent Antitumor Activity and a Superior Safety Profile for Cancer Therapy

(2011) W. Ying et al.   MOLECULAR CANCER THERAPEUTICS

A Network of Its Own: The Unique Interactome of the Hsp90 Cochaperone, Sba1/p23

(2011) Thomas Prince et al.   MOLECULAR CELL

Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity

(2011) Mehdi Mollapour et al.   MOLECULAR CELL

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

(2011) Kamalika Moulick et al.   Nature Chemical Biology

Extracellular Heat Shock Protein (Hsp)70 and Hsp90α Assist in Matrix Metalloproteinase-2 Activation and Breast Cancer Cell Migration and Invasion

(2011) Jessica D. Sims et al.   PLoS One

An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine

(2011) Pablo C. Echeverría et al.   PLoS One

HSP90 modulates actin dynamics: Inhibition of HSP90 leads to decreased cell motility and impairs invasion

(2010) Aftab Taiyab et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation

(2010) Jessica McCready et al.   BMC CANCER

Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions

(2010) Flora Zagouri et al.   BMC CANCER

Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits

(2010) Dimitris Stellas et al.   BMC CELL BIOLOGY

Hsp90 phosphorylation, Wee1 and the cell cycle

(2010) Mehdi Mollapour et al.   CELL CYCLE

Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma

(2010) Hiroshi Kubota et al.   CELL STRESS & CHAPERONES

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

(2010) Patrick Fadden et al.   CHEMISTRY & BIOLOGY

Heat Shock Protein 90 Inhibition in Lung Cancer

(2010) Takeshi Shimamura et al.   Journal of Thoracic Oncology

Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function

(2010) Mehdi Mollapour et al.   MOLECULAR CELL

New developments in Hsp90 inhibitors as anti-cancer therapeutics: Mechanisms, clinical perspective and more potential

(2009) Yanyan Li et al.   DRUG RESISTANCE UPDATES

Hsp90 is regulated by a switch point in the C-terminal domain

(2009) Marco Retzlaff et al.   EMBO REPORTS

Expression of Hsp90 chaperome proteins in human tumor tissue

(2009) Christina L. McDowell et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

HDAC6 Modulates Hsp90 Chaperone Activity and Regulates Activation of Aryl Hydrocarbon Receptor Signaling

(2009) Vikram D. Kekatpure et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

(2009) Kenneth H. Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional Proteomics Identifies Targets of Phosphorylation by B-Raf Signaling in Melanoma

(2009) William M. Old et al.   MOLECULAR CELL

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain

(2009) Shinji Tsutsumi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy

(2009) Xiaofeng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin

(2008) J. L. Holmes et al.   CANCER RESEARCH

Role of Acetylation and Extracellular Location of Heat Shock Protein 90  in Tumor Cell Invasion

(2008) Y. Yang et al.   CANCER RESEARCH

Significance of heat-shock protein (HSP) 90 expression in acute myeloid leukemia cells

(2008) Pascale Flandrin et al.   CELL STRESS & CHAPERONES

SNX2112, a Synthetic Heat Shock Protein 90 Inhibitor, Has Potent Antitumor Activity against HER Kinase Dependent Cancers

(2008) S. Chandarlapaty et al.   CLINICAL CANCER RESEARCH

The ATPase Cycle of the Mitochondrial Hsp90 Analog Trap1

(2008) Adriane Leskovar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Apoptosome Formation by Suppression of Hsp90  Phosphorylation in Tyrosine Kinase-Induced Leukemias

(2008) M. Kurokawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Transforming Growth Factor   (TGF )-Stimulated Secretion of HSP90 : Using the Receptor LRP-1/CD91 To Promote Human Skin Cell Migration against a TGF -Rich Environment during Wound Healing

(2008) C.-F. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Membrane and membrane-associated proteins involved in the aggressive phenotype displayed by highly invasive cancer cells

(2008) Paul Dowling et al.   PROTEOMICS

Prostate cancer serum biomarker discovery through proteomic analysis of alpha-2 macroglobulin protein complexes

(2008) Earle F. Burgess et al.   Proteomics Clinical Applications