Inverse electron demand Diels-Alder (IEDDA) reactions in peptide chemistry

Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics

(2018) Miloš Erak et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Tetrazine-Labile Vinyl Ether Benzyloxycarbonyl Protecting Group (VeZ): An Orthogonal Tool for Solid-Phase Peptide Chemistry

(2018) Matteo Staderini et al.   ORGANIC LETTERS

Efficient 18 F Labeling of Cysteine-Containing Peptides and Proteins Using Tetrazine– Trans -Cyclooctene Ligation

(2018) Shuanglong Liu et al.   Molecular Imaging

A One-Pot Three-Component Double-Click Method for Synthesis of [67Cu]-Labeled Biomolecular Radiotherapeutics

(2017) Katsumasa Fujiki et al.   Scientific Reports

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

(2016) Ester Jiménez-Moreno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multifunctional Coating Improves Cell Adhesion on Titanium by using Cooperatively Acting Peptides

(2016) Mareen Pagel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In situ activation of a doxorubicin prodrug using imaging-capable nanoparticles

(2016) Irfan Khan et al.   CHEMICAL COMMUNICATIONS

Rapid Bioorthogonal Chemistry Turn-on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation

(2016) Han Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diels–Alder Reactivities of Benzene, Pyridine, and Di-, Tri-, and Tetrazines: The Roles of Geometrical Distortions and Orbital Interactions

(2016) Yun-Fang Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development and application of bond cleavage reactions in bioorthogonal chemistry

(2016) Jie Li et al.   Nature Chemical Biology

On-resin Diels–Alder reaction with inverse electron demand: an efficient ligation method for complex peptides with a varying spacer to optimize cell adhesion

(2016) Mareen Pagel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A trifunctional linker suitable for conducting three orthogonal click chemistries in one pot

(2016) Astrid-Caroline Knall et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Improved Metabolic Stability for 18F PET Probes Rapidly Constructed via Tetrazine trans-Cyclooctene Ligation

(2015) Ramajeyam Selvaraj et al.   BIOCONJUGATE CHEMISTRY

Combination of inverse electron-demand Diels–Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations

(2015) S. Hörner et al.   CHEMICAL COMMUNICATIONS

Origin of Orthogonality of Strain-Promoted Click Reactions

(2015) Johannes A. Wagner et al.   CHEMISTRY-A EUROPEAN JOURNAL

Transition-metal-mediated uncaging in living human cells—an emerging alternative to photolabile protecting groups

(2015) Timo Völker et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Drug delivery and release systems for targeted tumor therapy

(2015) David Böhme et al.   JOURNAL OF PEPTIDE SCIENCE

Electrochemical Control of Rapid Bioorthogonal Tetrazine Ligations for Selective Functionalization of Microelectrodes

(2015) Fabian Ehret et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide/Protein Stapling and Unstapling: Introduction of s-Tetrazine, Photochemical Release, and Regeneration of the Peptide/Protein

(2015) Stephen P. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct access to site-specifically phosphorylated-lysine peptides from a solid-support

(2015) Jordi Bertran-Vicente et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

CuAAC: An Efficient Click Chemistry Reaction on Solid Phase

(2015) Vida Castro et al.   ACS Combinatorial Science

Alkene-Tetrazine Ligation for Imaging Cellular DNA

(2014) Ulrike Rieder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanding the scope of cyclopropene reporters for the detection of metabolically engineered glycoproteins by Diels–Alder reactions

(2014) Anne-Katrin Späte et al.   Beilstein Journal of Organic Chemistry

Site-Specific Labeling of Proteins and Peptides withTrans-cyclooctene Containing Handles Capable of Tetrazine Ligation

(2014) James W. Wollack et al.   Chemical Biology & Drug Design

“Click” reactions: a versatile toolbox for the synthesis of peptide-conjugates

(2014) Wen Tang et al.   CHEMICAL SOCIETY REVIEWS

Terminal Alkenes as Versatile Chemical Reporter Groups for Metabolic Oligosaccharide Engineering

(2014) Anne-Katrin Späte et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells

(2014) Jie Li et al.   Nature Chemical Biology

Solid phase oxime ligations for the iterative synthesis of polypeptide conjugates

(2014) Isidore E. Decostaire et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis

(2014) Brian M. Zeglis et al.   ChemistryOpen

Two-Color Glycan Labeling of Live Cells by a Combination of Diels-Alder and Click Chemistry

(2013) Andrea Niederwieser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

(2013) Ron M. Versteegen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diels–Alder Mediated Controlled Release from a Poly(ethylene glycol) Based Hydrogel

(2013) Kenneth Christopher Koehler et al.   BIOMACROMOLECULES

Synthetically Tractable Click Hydrogels for Three-Dimensional Cell Culture Formed Using Tetrazine–Norbornene Chemistry

(2013) Daniel L. Alge et al.   BIOMACROMOLECULES

Inverse electron demand Diels–Alder (iEDDA)-initiated conjugation: a (high) potential click chemistry scheme

(2013) Astrid-Caroline Knall et al.   CHEMICAL SOCIETY REVIEWS

1,2,3-Triazoles as Amide-bond Surrogates in Peptidomimetics

(2013) Ibai E. Valverde et al.   CHIMIA

Expanding room for tetrazine ligations in the in vivo chemistry toolbox

(2013) Jolita Šečkutė et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The inverse electron demand Diels-Alder click reaction in radiochemistry

(2013) Thomas Reiner et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Development and Evaluation of 18F-TTCO-Cys40-Exendin-4: A PET Probe for Imaging Transplanted Islets

(2013) Z. Wu et al.   JOURNAL OF NUCLEAR MEDICINE

Click Chemistry in Peptide-Based Drug Design

(2013) Huiyuan Li et al.   MOLECULES

Synthesis and evaluation of an 18F-labelled norbornene derivative for copper-free click chemistry reactions

(2013) James C. Knight et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities

(2012) Lianne I. Willems et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocompatible Silicon Surfaces through Orthogonal Click Chemistries and a High Affinity Silicon Oxide Binding Peptide

(2012) Rayk Hassert et al.   BIOCONJUGATE CHEMISTRY

Preparation of Carbohydrate Arrays by Using Diels-Alder Reactions with Inverse Electron Demand

(2012) Henning S. G. Beckmann et al.   CHEMISTRY-A EUROPEAN JOURNAL

Functionalized Cyclopropenes As Bioorthogonal Chemical Reporters

(2012) David M. Patterson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Theranostic cRGD-BioShuttle Constructs Containing Temozolomide- and Cy7 For NIR-Imaging and Therapy

(2012) Manfred Wiessler et al.   Theranostics

Biomedical Applications of Tetrazine Cycloadditions

(2011) Neal K. Devaraj et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and In Vivo Imaging of a 18F-Labeled PARP1 Inhibitor Using a Chemically Orthogonal Scavenger-Assisted High-Performance Method

(2011) Thomas Reiner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

(2011) Carlos Mas-Moruno et al.   Anti-Cancer Agents in Medicinal Chemistry

Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation

(2011) Mark R. Karver et al.   BIOCONJUGATE CHEMISTRY

Tetrazine-trans-cyclooctene ligation for the rapid construction of integrin αvβ3 targeted PET tracer based on a cyclic RGD peptide

(2011) Ramajeyam Selvaraj et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Diels–Alder Cycloaddition for Fluorophore Targeting to Specific Proteins inside Living Cells

(2011) Daniel S. Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Treatment of glioblastoma multiforme cells with temozolomide-BioShuttle ligated by the inverse Diels-Alder ligation chemistry

(2010) Klaus Braun   Drug Design Development and Therapy

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoselective immobilization of biomolecules through aqueous Diels–Alder and PEG chemistry

(2008) Xue-Long Sun et al.   TETRAHEDRON LETTERS