Combination of inverse electron-demand Diels–Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations

Generating Site-Specifically Modified Proteins via a Versatile and Stable Nucleophilic Carbon Ligation

(2015) Romas Kudirka et al.   CHEMISTRY & BIOLOGY

Potent inhibitors of human matriptase-1 based on the scaffold of sunflower trypsin inhibitor

(2014) Heiko Fittler et al.   JOURNAL OF PEPTIDE SCIENCE

Theoretical Elucidation of the Origins of Substituent and Strain Effects on the Rates of Diels–Alder Reactions of 1,2,4,5-Tetrazines

(2014) Fang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal

(2014) Thomas S Elliott et al.   NATURE BIOTECHNOLOGY

RNA–peptide conjugate synthesis by inverse-electron demand Diels–Alder reaction

(2014) Sandeep Ameta et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Acylazetine as a Dienophile in Bioorthogonal Inverse Electron-Demand Diels–Alder Ligation

(2014) Sander B. Engelsma et al.   ORGANIC LETTERS

Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis

(2014) Brian M. Zeglis et al.   ChemistryOpen

Bioorthogonal Approach to Identify Unsuspected Drug Targets in Live Cells

(2013) Katherine S. Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two-Color Glycan Labeling of Live Cells by a Combination of Diels-Alder and Click Chemistry

(2013) Andrea Niederwieser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

18F-Labeled-Bioorthogonal Liposomes for In Vivo Targeting

(2013) Fabien Emmetiere et al.   BIOCONJUGATE CHEMISTRY

α-Oxo Aldehyde or Glyoxylyl Group Chemistry in Peptide Bioconjugation

(2013) Ouafâa El-Mahdi et al.   BIOCONJUGATE CHEMISTRY

Inverse electron demand Diels–Alder (iEDDA)-initiated conjugation: a (high) potential click chemistry scheme

(2013) Astrid-Caroline Knall et al.   CHEMICAL SOCIETY REVIEWS

Expanding room for tetrazine ligations in the in vivo chemistry toolbox

(2013) Jolita Šečkutė et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein conjugation with genetically encoded unnatural amino acids

(2013) Chan Hyuk Kim et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Isomeric Cyclopropenes Exhibit Unique Bioorthogonal Reactivities

(2013) David N. Kamber et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combinatorial Optimization of Cystine-Knot Peptides towards High-Affinity Inhibitors of Human Matriptase-1

(2013) Bernhard Glotzbach et al.   PLoS One

Biocompatible Silicon Surfaces through Orthogonal Click Chemistries and a High Affinity Silicon Oxide Binding Peptide

(2012) Rayk Hassert et al.   BIOCONJUGATE CHEMISTRY

Application of Strain-Promoted Azide–Alkyne Cycloaddition and Tetrazine Ligation to Targeted Fc-Drug Conjugates

(2012) Joshua D. Thomas et al.   BIOCONJUGATE CHEMISTRY

Preparation of Carbohydrate Arrays by Using Diels-Alder Reactions with Inverse Electron Demand

(2012) Henning S. G. Beckmann et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemical proteomics: ligation and cleavage of protein modifications

(2012) Georg C Rudolf et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry

(2012) Manfred Wiessler et al.   International Journal of Medical Sciences

Genetically Encoded Tetrazine Amino Acid Directs Rapid Site-Specific in Vivo Bioorthogonal Ligation with trans-Cyclooctenes

(2012) Jason L. Seitchik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions

(2012) Kathrin Lang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-specific chemical protein conjugation using genetically encoded aldehyde tags

(2012) David Rabuka et al.   Nature Protocols

From pico to nano: biofunctionalization of cube-octameric silsesquioxanes by peptides and miniproteins

(2012) Sebastian Fabritz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bioconjugation on cube-octameric silsesquioxanes

(2012) Sebastian Fabritz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Modular Strategy for the Construction of Radiometalated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels–Alder Click Chemistry

(2011) Brian M. Zeglis et al.   BIOCONJUGATE CHEMISTRY

Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation

(2011) Mark R. Karver et al.   BIOCONJUGATE CHEMISTRY

Strain-Promoted Alkyne-Azide Cycloadditions (SPAAC) Reveal New Features of Glycoconjugate Biosynthesis

(2011) Ngalle Eric Mbua et al.   CHEMBIOCHEM

Post-translational modification of genetically encoded polypeptide libraries

(2011) Alessandro Angelini et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein Modification by Strain-Promoted Alkyne-Nitrone Cycloaddition

(2010) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice

(2010) Raffaella Rossin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells

(2010) Neal K. Devaraj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes

(2010) Zibo Li et al.   CHEMICAL COMMUNICATIONS

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection

(2010) Jered B. Haun et al.   Nature Nanotechnology

Copper-free click chemistry in living animals

(2010) P. V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Growing Applications of “Click Chemistry” for Bioconjugation in Contemporary Biomedical Research

(2009) Kido Nwe et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Advances in Bioconjugation

(2009) Jeet Kalia et al.   CURRENT ORGANIC CHEMISTRY

Inverse-electron-demand Diels-Alder reaction as a highly efficient chemoselective ligation procedure: Synthesis and function of a BioShuttle for temozolomide transport into prostate cancer cells

(2009) Rüdiger Pipkorn et al.   JOURNAL OF PEPTIDE SCIENCE

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

1-Ethoxyethylidene, a New Group for the Stepwise SPPS of Aminooxyacetic Acid Containing Peptides

(2008) Stéphanie Foillard et al.   JOURNAL OF ORGANIC CHEMISTRY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-specific N-terminal labelling of proteinsin vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry

(2007) William P. Heal et al.   CHEMICAL COMMUNICATIONS