The genetics of NAFLD

The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study

(2013) Mary F. Feitosa et al.   ATHEROSCLEROSIS

Characterization of european ancestry nonalcoholic fatty liver disease-associated variants in individuals of african and hispanic descent

(2013) Nicholette D. Palmer et al.   HEPATOLOGY

Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan

(2013) Takuya Kitamoto et al.   HUMAN GENETICS

Genetic Variation at NCAN Locus Is Associated with Inflammation and Fibrosis in Non-Alcoholic Fatty Liver Disease in Morbid Obesity

(2013) Alexis Gorden et al.   HUMAN HEREDITY

1275 CARRIAGE OF PNPLA3 I148M IS ASSOCIATED WITH AN INCREASED RISK OF NON-ALCOHOLIC FATTY LIVER DIESEASE ASSOCIATED HEPATOCELLULAR CARCINOMA

(2013) Y.-L. Liu et al.   JOURNAL OF HEPATOLOGY

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Susceptibility and Gene Interaction Study of the Angiotensin II Type 1 Receptor (AGTR1) Gene Polymorphisms with Non-Alcoholic Fatty Liver Disease in a Multi-Ethnic Population

(2013) Shamsul Mohd Zain et al.   PLoS One

Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase

(2012) Manju Kumari et al.   Cell Metabolism

Unraveling the genetics of fatty liver in obese children: Additive effect of P446L GCKR and I148M PNPLA3 polymorphisms

(2012) Luca Valenti et al.   HEPATOLOGY

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis

(2012) John Zhong Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro

(2012) Carlo Pirazzi et al.   JOURNAL OF HEPATOLOGY

Multigenerational epigenetic adaptation of the hepatic wound-healing response

(2012) Müjdat Zeybel et al.   NATURE MEDICINE

Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese

(2012) Takahisa Kawaguchi et al.   PLoS One

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study

(2011) R. M. Williamson et al.   DIABETES CARE

Polymorphism in the Farnesyl Diphosphate Farnesyl Transferase 1 Gene and Nonalcoholic Fatty Liver Disease Severity

(2011) Stefano Ballestri et al.   GASTROENTEROLOGY

Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents

(2011) Nicola Santoro et al.   HEPATOLOGY

Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease

(2011) Lars P. Bechmann et al.   HEPATOLOGY

Ethnicity and nonalcoholic fatty liver disease

(2011) Kiran Bambha et al.   HEPATOLOGY

Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease

(2011) Yongcheng Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver

(2011) Luca Valenti et al.   JOURNAL OF HEPATOLOGY

Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort

(2011) Matthew J. Armstrong et al.   JOURNAL OF HEPATOLOGY

The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies

(2011) Ahmad Al-Serri et al.   JOURNAL OF HEPATOLOGY

Lack of effect of apolipoprotein C3 polymorphisms on indices of liver steatosis, lipid profile and insulin resistance in obese Southern Europeans

(2011) Federica Sentinelli et al.   Lipids in Health and Disease

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis

(2011) George F Mells et al.   NATURE GENETICS

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

(2011) John C Chambers et al.   NATURE GENETICS

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity

(2010) Giovanni Musso et al.   ANNALS OF MEDICINE

Genome-Wide Association Studies: Results from the First Few Years and Potential Implications for Clinical Medicine

(2010) Joel N. Hirschhorn et al.   Annual Review of Medicine

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein

(2010) Stefano Romeo et al.   CURRENT OPINION IN LIPIDOLOGY

Genome-Wide Association Study Identifies Variants Associated With Histologic Features of Nonalcoholic Fatty Liver Disease

(2010) Naga Chalasani et al.   GASTROENTEROLOGY

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

(2010) Christopher D. Williams et al.   GASTROENTEROLOGY

Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance

(2010) Julia Kozlitina et al.   HEPATOLOGY

Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease

(2010) Weiqin Chen et al.   HEPATOLOGY

I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

(2010) Nicola Santoro et al.   HEPATOLOGY

Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease

(2010) Kausik Das et al.   HEPATOLOGY

PNPLA3variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease

(2010) Elizabeth K. Speliotes et al.   HEPATOLOGY

The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease

(2010) Yaron Rotman et al.   HEPATOLOGY

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis

(2010) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life

(2010) Stefano Romeo et al.   JOURNAL OF HEPATOLOGY

A position statement on NAFLD/NASH based on the EASL 2009 special conference

(2010) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

(2010) Mahesh K. Basantani et al.   JOURNAL OF LIPID RESEARCH

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

(2010) Xiangdong Liu et al.   NATURE GENETICS

Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease

(2010) Kitt Falk Petersen et al.   NEW ENGLAND JOURNAL OF MEDICINE

A feed-forward loop amplifies nutritional regulation of PNPLA3

(2010) Yongcheng Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology and Natural History of Non-Alcoholic Steatohepatitis

(2009) Curtis K. Argo et al.   Clinics in Liver Disease

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene

(2009) K. Kantartzis et al.   DIABETES

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

(2009) A. Kotronen et al.   DIABETOLOGIA

Angiotensin II Activates IκB Kinase Phosphorylation of RelA at Ser536 to Promote Myofibroblast Survival and Liver Fibrosis

(2009) Fiona Oakley et al.   GASTROENTEROLOGY

Heritability of Nonalcoholic Fatty Liver Disease

(2009) Jeffrey B. Schwimmer et al.   GASTROENTEROLOGY

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

(2009) Nicola L. Beer et al.   HUMAN MOLECULAR GENETICS

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

(2009) S Romeo et al.   INTERNATIONAL JOURNAL OF OBESITY

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

(2009) Shaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression

(2009) Geoffrey C Farrell et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: A study in monozygotic and dizygotic twins

(2009) Janne Makkonen et al.   JOURNAL OF HEPATOLOGY

Validity of real time ultrasound in the diagnosis of hepatic steatosis: A prospective study

(2009) Srinivasan Dasarathy et al.   JOURNAL OF HEPATOLOGY

Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance

(2009) Nina F. Schwenzer et al.   JOURNAL OF HEPATOLOGY

The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status

(2009) Menno Hoekstra et al.   JOURNAL OF HEPATOLOGY

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

(2009) Silvia Sookoian et al.   JOURNAL OF LIPID RESEARCH

A common variant in the adiponutrin gene influences liver enzyme values

(2009) B. Kollerits et al.   JOURNAL OF MEDICAL GENETICS

Association between angiotensin II type 1 receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease

(2009) Masato Yoneda et al.   LIVER INTERNATIONAL

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

(2009) Yoichiro Kamatani et al.   NATURE GENETICS

Primary Biliary Cirrhosis Associated withHLA, IL12A,andIL12RB2Variants

(2009) Gideon M. Hirschfield et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomewide Association Studies — Illuminating Biologic Pathways

(2009) Joel N. Hirschhorn   NEW ENGLAND JOURNAL OF MEDICINE

Genomewide Association Studies and Human Disease

(2009) John Hardy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes

(2008) Xin Yuan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue

(2008) Jeremy F. L. Cobbold et al.   CLINICAL SCIENCE

The Kruppel-Like Factor 6 Genotype Is Associated With Fibrosis in Nonalcoholic Fatty Liver Disease

(2008) Luca Miele et al.   GASTROENTEROLOGY

Ethnic differences in hepatic steatosis: An insulin resistance paradox?

(2008) Richard Guerrero et al.   HEPATOLOGY

Genome-wide association studies: past, present and future

(2008) M. I. McCarthy et al.   HUMAN MOLECULAR GENETICS

A HapMap harvest of insights into the genetics of common disease

(2008) Teri A. Manolio et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver biopsy findings from healthy potential living liver donors: Reasons for disqualification, silent diseases and correlation with liver injury tests

(2008) Marta I. Minervini et al.   JOURNAL OF HEPATOLOGY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

(2008) Cristen J Willer et al.   NATURE GENETICS

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

(2008) Yurii S Aulchenko et al.   NATURE GENETICS

Genetic Mapping in Human Disease

(2008) D. Altshuler et al.   SCIENCE