Article
Neurosciences
Ziying Zhu, Xiaona Zhang, Haojie Hao, Heran Xu, Jun Shu, Qian Hou, Min Wang
Summary: Exosomes derived from umbilical cord mesenchymal stem cells (UC-MSCs) play a key role in promoting wound repair and skin regeneration by recruiting and stimulating fibroblasts to secrete nerve growth factors (NGFs) for skin nerve repair.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Claudia Griselda Cardenas-Leon, Kristina Maemets-Allas, Mariliis Klaas, Heli Lagus, Esko Kankuri, Viljar Jaks
Summary: Cutaneous wound healing is a complex process that involves changes in all aspects of the skin. The extracellular matrix (ECM) is composed of structural proteins and matricellular proteins, which have regulatory properties. Matricellular proteins interact with structural proteins, cell surface receptors, cytokines, or proteases to initiate a cellular response. The signaling initiated by matricellular proteins regulates cell differentiation and proliferation, affecting tissue regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kotaro Tanaka, Ryohei Ogino, Sho Yamakawa, Shota Suda, Kenji Hayashida
Summary: Skin wounds usually heal on their own, but this is only true for healthy individuals. Mesenchymal stem cells (MSCs) have been found to play a significant role in wound healing and regeneration, with their ability to self-renew and differentiate, as well as their anti-inflammatory and immunomodulatory properties. This review aims to explain the functions and effects of MSCs in wound healing.
Review
Pharmacology & Pharmacy
Feiyu Cai, Wenjiao Chen, Ruomei Zhao, Yi Liu
Summary: This paper provides an academic review of the therapeutic effects of adipose-derived stem cell-EXOs (ADSC-EXOs) in diabetic wound healing. As cell-free therapy, exosomes (EXOs) contain proteins and growth factors that can promote wound healing and mitigate potential risks associated with stem cell therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Chun-Wei Li, Tai-Horng Young, Mu-Hui Wang, Ming-Ying Pei, Tsung-Yu Hsieh, Chia-Lang Hsu, Nai-Chen Cheng
Summary: Our study demonstrates that a diabetic environment has an adverse effect on ASCs, and adopting a low glucose culture condition is a simple and effective way to enhance the wound healing capabilities of diabetic ASCs. This finding is valuable for the clinical application of autologous ASCs from diabetic patients.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Polymer Science
Shaima Maliha Riha, Manira Maarof, Mh Busra Fauzi
Summary: Skin tissue engineering has made significant progress in wound healing treatment by incorporating stem cells into biomaterials to enhance their delivery and therapeutic effects. The use of biomaterials as a platform improves the engraftment of implanted cells and facilitates the function of exogenous cells by mimicking the tissue microenvironment.
Review
Biochemistry & Molecular Biology
Yulia Suzdaltseva, Sergey L. Kiselev
Summary: Scar formation during normal tissue regeneration in adults can have negative effects on appearance and function. Fetal tissues, on the other hand, are capable of complete regeneration. Understanding the cellular and molecular mechanisms of fetal wound regeneration can lead to successful treatments for minimizing scarring. However, limited access to fetal material hinders research in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Yuzhen Wang, Xingyu Yuan, Bin Yao, Shuoji Zhu, Ping Zhu, Sha Huang
Summary: This review discusses the potential and limitations of extrusion-based bioprinting (EBB) for skin regeneration, and introduces strategies for improving the physical properties of bioinks and reinforcing bioinks in EBB approaches. It highlights the applications and effects of current EBB-based bioinks on wound healing, wound scar formation, vascularization, and the regeneration of skin appendages, along with the challenges and future perspectives.
BIOACTIVE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Daniel Diaz-Garcia, Alzbeta Filipova, Idalia Garza-Veloz, Margarita L. Martinez-Fierro
Summary: The skin serves as a physical barrier against environmental threats and pathogens, with its regeneration relying on various skin stem cell compartments. While skin wounds typically heal without issue, certain conditions or severe damage can impede the healing process. Non-healing wounds present a serious and potentially life-threatening situation that may necessitate advanced therapeutic interventions, with a focus on stem cells playing a significant role in potential treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Zhengbo Wen, Yuxin Chen, Peilin Liao, Fengyu Wang, Weiping Zeng, Shoupei Liu, Haibing Wu, Ning Wang, Lorenzo Moroni, Minmin Zhang, Yuyou Duan, Honglin Chen
Summary: In this study, an in situ cell electrospinning system was developed as an attractive approach for stem cell delivery, which could promote cutaneous wound healing through direct deposition of bioactive fish gelatin fibers and MSCs onto wound sites, leading to a synergistic therapeutic effect.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Xiya Yin, Qingfeng Li, Patrick Michael McNutt, Yuanyuan Zhang
Summary: Epithelial tissue injuries can have significant impacts on patients' quality of life, healthcare spending, and global economy. Urine-derived stem cells show versatile potential for tissue regeneration in repairing epidermal and urothelial injuries.
Article
Biochemistry & Molecular Biology
Shih-Heng Chen, Zhi-Yu Chen, Ya-Hsuan Lin, Shih-Hsien Chen, Pang-Yun Chou, Huang-Kai Kao, Feng-Huei Lin
Summary: This study demonstrated that extracellular vesicles (EVs) derived from adipose-derived stem cells (ADSCs) significantly enhanced tendon regeneration by promoting proliferation and migration of tenocytes. Treatment with ADSC-EVs also improved the mechanical strength of repaired tendons, suggesting a potentially highly potent therapeutic strategy for tendon injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Xiaoting Liang, Fang Lin, Yue Ding, Yuelin Zhang, Mimi Li, Xiaohui Zhou, Qingshu Meng, Xiaoxue Ma, Lu Wei, Huimin Fan, Zhongmin Liu
Summary: This study compared the effectiveness of conditioned medium of MSCs derived from induced pluripotent stem cells (iMSC-CdM) with that derived from umbilical cord MSCs (uMSC-CdM) in a mouse cutaneous wound healing model. The iMSC-CdM was found to be superior to uMSC-CdM in accelerating wound closure, enhancing angiogenesis, and protecting HUVECs from H2O2-induced injury via the ERK pathway. Collectively, iMSC-CdM may serve as a more constant and sustainable source for cell-free therapeutic approach in treating cutaneous wounds.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Anatomy & Morphology
Sana Ullah, Sumaiya Mansoor, Aaima Ayub, Momina Ejaz, Hajrah Zafar, Fizza Feroz, Ayyaz Khan, Muhammad Ali
Summary: Burn wounds can have long-lasting devastating effects on the human body, and conventional therapies are often ineffective at completely healing them. Stem cells have shown promising potential in promoting healing of burn wounds, offering advantages such as faster healing, reduced inflammation, and scar progression, making them a potential more efficient alternative to current treatments.
Editorial Material
Multidisciplinary Sciences
David J. J. Glass
Summary: Senescent cells in skeletal muscle promote inflammation and hinder regeneration, potentially causing harmful changes in aged muscle.