FLCN is a novel Rab11A-interacting protein that is involved in the Rab11A-mediated recycling transport

FLCN : The causative gene for Birt-Hogg-Dubé syndrome

(2018) Laura S. Schmidt et al.   GENE

The amino acid transporter PAT1 regulates mTORC1 in a nutrient-sensitive manner that requires its transport activity

(2018) Lingling Zhao et al.   CELLULAR SIGNALLING

Amino acids suppress the expression of PAT1 on lysosomes via inducing the cleavage of a targeting signal

(2017) Xin Ji et al.   FEBS LETTERS

Glycosylation affects the stability and subcellular distribution of human PAT1 protein

(2017) Hongjie Luo et al.   FEBS LETTERS

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

(2017) Laura A. Laviolette et al.   Nature Communications

Folliculin Interacts with Rab35 to Regulate EGF-Induced EGFR Degradation

(2017) Jianchao Zheng et al.   Frontiers in Pharmacology

Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis

(2016) Emma J. Kenyon et al.   BMC DEVELOPMENTAL BIOLOGY

Folliculin directs the formation of a Rab34–RILP complex to control the nutrient‐dependent dynamic distribution of lysosomes

(2016) Georgina P Starling et al.   EMBO REPORTS

Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure

(2016) Masaya Baba et al.   STEM CELLS

FLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1

(2016) Xiaochun Wu et al.   PLoS One

Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2

(2015) Marie-Pierre Péli-Gulli et al.   Cell Reports

Orchestration of cell surface proteins by Rab11

(2014) Tobias Welz et al.   TRENDS IN CELL BIOLOGY

Folliculin Regulates Ampk-Dependent Autophagy and Metabolic Stress Survival

(2014) Elite Possik et al.   PLoS Genetics

Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner

(2013) Hakam Gharbi et al.   AGING CELL

PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats

(2013) Anne Jensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

(2013) Constance S. Petit et al.   JOURNAL OF CELL BIOLOGY

The armadillo protein p0071 is involved in Rab11-dependent recycling

(2013) R. Keil et al.   JOURNAL OF CELL SCIENCE

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

Genetic Characterization of the Drosophila Birt-Hogg-Dubé Syndrome Gene

(2013) Wei Liu et al.   PLoS One

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

(2012) Michael S. Nahorski et al.   HUMAN MOLECULAR GENETICS

Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes

(2012) Margrét H. Ögmundsdóttir et al.   PLoS One

Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

(2012) Doug A. Medvetz et al.   PLoS One

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

(2012) R. K. Nookala et al.   Open Biology

The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport

(2011) David T Thwaites et al.   BRITISH JOURNAL OF PHARMACOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation

(2010) S Heublein et al.   ONCOGENE

The dynamic Rab11-FIPs

(2009) Conor P. Horgan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Identification of a Disulfide Bridge Essential for Transport Function of the Human Proton-coupled Amino Acid Transporter hPAT1

(2009) Madlen Dorn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sorting of lysosomal proteins

(2008) Thomas Braulke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Deficiency of FLCN in Mouse Kidney Led to Development of Polycystic Kidneys and Renal Neoplasia

(2008) Jindong Chen et al.   PLoS One