Translating advances in organ-on-a-chip technology for supporting organs

Organ-on-a-Chip

(2018) Nureddin A. Ashammakhi et al.   JOURNAL OF CRANIOFACIAL SURGERY

Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip

(2018) Sasan Jalili-Firoozinezhad et al.   Cell Death & Disease

Concept and Computational Design for a Bioartificial Nephron-On-A-Chip

(2018) E. Weinberg et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Kidney-on-a-chip: untapped opportunities

(2018) Nureddin Ashammakhi et al.   KIDNEY INTERNATIONAL

Single cell-laden protease-sensitive microniches for long-term culture in 3D

(2017) Philipp S. Lienemann et al.   LAB ON A CHIP

The promise of organ and tissue preservation to transform medicine

(2017) Sebastian Giwa et al.   NATURE BIOTECHNOLOGY

Microfluidic guillotine for single-cell wound repair studies

(2017) Lucas R. Blauch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease

(2017) Kelly R. Stevens et al.   Science Translational Medicine

Glomerulus-on-a-Chip. Life Up

(2017) Nureddin Ashammakhi et al.   TRANSPLANTATION

Recent lab-on-chip developments for novel drug discovery

(2017) Nauman Khalid et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Bioprinted Osteogenic and Vasculogenic Patterns for Engineering 3D Bone Tissue

(2017) Batzaya Byambaa et al.   Advanced Healthcare Materials

Label-Free and Regenerative Electrochemical Microfluidic Biosensors for Continual Monitoring of Cell Secretomes

(2017) Su Ryon Shin et al.   Advanced Science

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis

(2016) Zhiyun Xu et al.   ACS Applied Materials & Interfaces

Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells

(2016) Hyeun Joong Yoon et al.   ADVANCED MATERIALS

Microfluidic technology enhances the potential of human pluripotent stem cells

(2016) Onelia Gagliano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

Elastomeric free-form blood vessels for interconnecting organs on chip systems

(2016) Weijia Zhang et al.   LAB ON A CHIP

Bioprinted thrombosis-on-a-chip

(2016) Yu Shrike Zhang et al.   LAB ON A CHIP

One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology

(2016) Hyungseok Lee et al.   LAB ON A CHIP

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

(2016) Johan U. Lind et al.   NATURE MATERIALS

Three-dimensional bioprinting of thick vascularized tissues

(2016) David B. Kolesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems

(2016) Fuyin Zheng et al.   Small

Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

(2016) Kimberly A. Homan et al.   Scientific Reports

Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low-Viscosity Bioink

(2015) Cristina Colosi et al.   ADVANCED MATERIALS

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

Long-term maintenance of a microfluidic 3D human liver sinusoid

(2015) Ljupcho Prodanov et al.   BIOTECHNOLOGY AND BIOENGINEERING

Liver sinusoid on a chip: Long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms

(2015) Young Bok Abraham Kang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury

(2015) Qing Zhou et al.   LAB ON A CHIP

A Multi-Center, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device in Patients with Acute Kidney Injury

(2015) James A. Tumlin et al.   PLoS One

Networked neural spheroid by neuro-bundle mimicking nervous system created by topology effect

(2015) Gi Seok Jeong et al.   Molecular Brain

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

An Integrated Array of Microfluidic Oxygenators as a Neonatal Lung Assist Device: In Vitro Characterization and In Vivo Demonstration

(2014) Niels Rochow et al.   ARTIFICIAL ORGANS

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

(2014) Simone Bersini et al.   BIOMATERIALS

A functional microengineered model of the human splenon-on-a-chip

(2014) L. G. Rigat-Brugarolas et al.   LAB ON A CHIP

Biomimetic Microfluidic Device for in Vitro Antihypertensive Drug Evaluation

(2014) Lei Li et al.   MOLECULAR PHARMACEUTICS

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Micropatterned Cell–Cell Interactions Enable Functional Encapsulation of Primary Hepatocytes in Hydrogel Microtissues

(2014) Cheri Y. Li et al.   TISSUE ENGINEERING PART A

Normothermic donor heart perfusion: current clinical experience and the future

(2014) Simon Messer et al.   TRANSPLANT INTERNATIONAL

Micropatterning Alginate Substrates for In Vitro Cardiovascular Muscle on a Chip

(2013) Ashutosh Agarwal et al.   ADVANCED FUNCTIONAL MATERIALS

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Artificial Placenta - Lung Assist Devices for Term and Preterm Newborns with Respiratory Failure

(2013) Niels Rochow et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

A Microfluidic Device with 3-D Hydrogel Villi Scaffold to Simulate Intestinal Absorption

(2013) Si Hyeon Kim et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

Liver-cell patterning Lab Chip: mimicking the morphology of liver lobule tissue

(2013) Chen-Ta Ho et al.   LAB ON A CHIP

Engineering a 3D vascular network in hydrogel for mimicking a nephron

(2013) Xuan Mu et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip

(2013) M. L. McCain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurovascular unit on a chip: implications for translational applications

(2013) Donald J Alcendor et al.   Stem Cell Research & Therapy

Keeping kidneys

(2012) Ben Jones   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

A modular approach to create a neurovascular unit-on-a-chip

(2012) Anil Kumar H. Achyuta et al.   LAB ON A CHIP

Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers

(2011) Jean-Michel Peyrin et al.   LAB ON A CHIP

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Organ Preservation: Current Concepts and New Strategies for the Next Decade

(2011) Edgardo E. Guibert et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

Hepatic Steatosis and Normothermic Perfusion—Preliminary Experiments in a Porcine Model

(2011) Russell W. Jamieson et al.   TRANSPLANTATION

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Micropatterning neural cell cultures in 3D with a multi-layered scaffold

(2010) Anja Kunze et al.   BIOMATERIALS

Trapping single human osteoblast-like cells from a heterogeneous population using a dielectrophoretic microfluidic device

(2010) Rupert S. W. Thomas et al.   Biomicrofluidics

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

(2010) Nicholas J. Douville et al.   LAB ON A CHIP

Wallerian-Like Degeneration of Central Neurons After Synchronized and Geometrically Registered Mass Axotomy in a Three-Compartmental Microfluidic Chip

(2010) Devrim Kilinc et al.   NEUROTOXICITY RESEARCH

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Biofabrication of a three-dimensional liver micro-organ as anin vitrodrug metabolism model

(2010) Robert Chang et al.   Biofabrication

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP