Non-Phosphorylated Tau in Cerebrospinal Fluid is a Marker of Alzheimer’s Disease Continuum in Young Urbanites Exposed to Air Pollution

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

(2018) Nazira J. Albargothy et al.   ACTA NEUROPATHOLOGICA

Nanoparticle-Cell Interaction: A Cell Mechanics Perspective

(2018) Dedy Septiadi et al.   ADVANCED MATERIALS

Biodistribution, Clearance, and Long-Term Fate of Clinically Relevant Nanomaterials

(2018) Joël Bourquin et al.   ADVANCED MATERIALS

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Fibre-specific white matter reductions in Alzheimer’s disease and mild cognitive impairment

(2018) Remika Mito et al.   BRAIN

Cortical tau pathology: a major player in fibre-specific white matter reductions in Alzheimer's disease?

(2018) Kirsty E McAleese et al.   BRAIN

Severe White Matter Astrocytopathy in CADASIL

(2018) Yoshiki Hase et al.   BRAIN PATHOLOGY

Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

(2018) Karen Horsburgh et al.   CLINICAL SCIENCE

The cellular prion protein promotes olfactory sensory neuron survival and axon targeting during adult neurogenesis

(2018) Lindsay E. Parrie et al.   DEVELOPMENTAL BIOLOGY

Hallmarks of Alzheimer disease are evolving relentlessly in Metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at ≤ 40 years of age

(2018) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults ≤ 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology

(2018) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

White matter tauopathy: Transient functional loss and novel myelin remodeling

(2018) Joshua Jackson et al.   GLIA

Whole brain white matter histogram analysis of diffusion tensor imaging data detects microstructural damage in mild cognitive impairment and alzheimer's disease patients

(2018) Giovanni Giulietti et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Inflammatory mediators reduce surface PrPc on human BMVEC resulting in decreased barrier integrity

(2018) Bezawit W. Megra et al.   LABORATORY INVESTIGATION

Neurofilament relates to white matter microstructure in older adults

(2018) Elizabeth E. Moore et al.   NEUROBIOLOGY OF AGING

Neurodegeneration, synaptic dysfunction, and gliosis are phenotypic of Alzheimer dementia

(2018) Andrew P. Merluzzi et al.   NEUROLOGY

Loss of white matter integrity reflects tau accumulation in Alzheimer disease defined regions

(2018) Jeremy F. Strain et al.   NEUROLOGY

The fine anatomy of the perivascular compartment in the human brain: relevance to dilated perivascular spaces in cerebral amyloid angiopathy

(2018) M. MacGregor Sharp et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study

(2018) Annemarie Goltz et al.   NEUROPSYCHOBIOLOGY

The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer’s disease

(2018) Mony J. de Leon et al.   PLoS One

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer’s disease

(2018) Sarah Ulbrich et al.   PLoS One

Neuronal pathophysiology featuring PrPC and its control over Ca2+ metabolism

(2018) Alessandro Bertoli et al.   Prion

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

(2018) Rikesh M. Rajani et al.   Science Translational Medicine

Prion protein modulates glucose homeostasis by altering intracellular iron

(2018) Ajay Ashok et al.   Scientific Reports

White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation

(2018) Charlotte E. Teunissen et al.   Alzheimers Research & Therapy

White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes

(2018) Grégory Operto et al.   Alzheimers Research & Therapy

BDNF Polymorphism: A Review of Its Diagnostic and Clinical Relevance in Neurodegenerative Disorders

(2018) Ting Shen et al.   Aging and Disease

CSF nonphosphorylated Tau as a biomarker for the discrimination of AD from CJD

(2018) Natalia Ermann et al.   Annals of Clinical and Translational Neurology

Neuroinflammation, Hyperphosphorylated Tau, Diffuse Amyloid Plaques, and Down-Regulation of the Cellular Prion Protein in Air Pollution Exposed Children and Young Adults

(2018) Lilian Calderón-Garcidueñas et al.   JOURNAL OF ALZHEIMERS DISEASE

Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner

(2018) Isidro Ferrer   PROGRESS IN NEUROBIOLOGY

Blood-Cerebrospinal Fluid Barrier Gradients in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Inflammatory Cytokines and Chemokines

(2018) Brian R. Ott et al.   Frontiers in Aging Neuroscience

Combustion-derived nanoparticles, the neuroenteric system, cervical vagus, hyperphosphorylated alpha synuclein and tau in young Mexico City residents

(2017) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

Apolipoprotein E4, Gender, Body Mass Index, Inflammation, Insulin Resistance, and Air Pollution Interactions: Recipe for Alzheimer’s Disease Development in Mexico City Young Females

(2017) Lilian Calderón-Garcidueñas et al.   JOURNAL OF ALZHEIMERS DISEASE

Combustion-Derived Nanoparticles in Key Brain Target Cells and Organelles in Young Urbanites: Culprit Hidden in Plain Sight in Alzheimer’s Disease Development

(2017) Angélica González-Maciel et al.   JOURNAL OF ALZHEIMERS DISEASE

White matter atrophy and myelinated fiber disruption in a rat model of depression

(2017) Yuan Gao et al.   JOURNAL OF COMPARATIVE NEUROLOGY

CSF β-amyloid and white matter damage: a new perspective on Alzheimer’s disease

(2017) Anna M Pietroboni et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Living near major roads and the incidence of dementia, Parkinson's disease, and multiple sclerosis: a population-based cohort study

(2017) Hong Chen et al.   LANCET

ApoE influences regional white-matter axonal density loss in Alzheimer's disease

(2017) Catherine F. Slattery et al.   NEUROBIOLOGY OF AGING

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

(2017) Piotr Lewczuk et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Cerebrospinal Fluid Biomarkers for Alzheimer's Disease

(2017) Kaj Blennow et al.   JOURNAL OF ALZHEIMERS DISEASE

Saturday Driving Restrictions Fail to Improve Air Quality in Mexico City

(2017) Lucas W. Davis   Scientific Reports

Interactive and additive influences of Gender, BMI and Apolipoprotein 4 on cognition in children chronically exposed to high concentrations of PM2.5 and ozone. APOE 4 females are at highest risk in Mexico City

(2016) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

Prefrontal white matter pathology in air pollution exposed Mexico City young urbanites and their potential impact on neurovascular unit dysfunction and the development of Alzheimer's disease

(2016) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

Cortical network dysfunction caused by a subtle defect of myelination

(2016) Giulia Poggi et al.   GLIA

Size-dependent cytotoxicity of Fe3O4 nanoparticles induced by biphasic regulation of oxidative stress in different human hepatoma cells

(2016) Pei Feng Liu et al.   International Journal of Nanomedicine

Non-Phosphorylated Tau as a Potential Biomarker of Alzheimer’s Disease: Analytical and Diagnostic Characterization

(2016) Piotr Lewczuk et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer’s and Parkinson’s Diseases in Young Mexico City Residents

(2016) Lilian Calderón-Garcidueñas et al.   JOURNAL OF ALZHEIMERS DISEASE

Size-Dependent Translocation Pattern, Chemical and Biological Transformation of Nano- and Submicron-Sized Ferric Oxide Particles in the Central Nervous System

(2016) Bing Wang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Albumin microvascular leakage in brains with diabetes mellitus

(2016) Ryuji Fujihara et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Vitamin D deficiency might pose a greater risk for ApoEɛ4 non-carrier Alzheimer’s disease patients

(2016) Erdinç Dursun et al.   NEUROLOGICAL SCIENCES

Magnetite pollution nanoparticles in the human brain

(2016) Barbara A. Maher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Functional Prion-Like Proteins in the Persistence of Memory

(2016) Kausik Si et al.   Cold Spring Harbor Perspectives in Biology

The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey

(2015) Martina Bocchetta et al.   Alzheimers & Dementia

Temporal evolution of biomarkers and cognitive markers in the asymptomatic, MCI, and dementia stage of Alzheimer's disease

(2015) Daniela Bertens et al.   Alzheimers & Dementia

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

(2015) Heiko Braak et al.   BRAIN

Populations potentially exposed to traffic-related air pollution in seven world cities

(2015) Jason G. Su et al.   ENVIRONMENT INTERNATIONAL

Mexico City normal weight children exposed to high concentrations of ambient PM2.5 show high blood leptin and endothelin-1, vitamin D deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for obesity and Alzheimer disease

(2015) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

White matter hyperintensities, cognitive impairment and dementia: an update

(2015) Niels D. Prins et al.   Nature Reviews Neurology

Lower Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor Predicts Progression from Mild Cognitive Impairment to Alzheimer’s Disease

(2015) Orestes Vicente Forlenza et al.   NEUROMOLECULAR MEDICINE

Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease

(2015) Yakeel T. Quiroz et al.   JAMA Neurology

Cortical tau load is associated with white matter hyperintensities

(2015) Kirsty E. McAleese et al.   Acta Neuropathologica Communications

Distribution of axon diameters in cortical white matter: an electron-microscopic study on three human brains and a macaque

(2014) Daniel Liewald et al.   BIOLOGICAL CYBERNETICS

White Matter Hypoperfusion and Damage in Dementia: Post-Mortem Assessment

(2014) Seth Love et al.   BRAIN PATHOLOGY

Vehicle Engines Produce Exhaust Nanoparticles Even When Not Fueled

(2014) Topi Rönkkö et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Pulsed Magnetic Field Improves the Transport of Iron Oxide Nanoparticles through Cell Barriers

(2013) Kyoung Ah Min et al.   ACS Nano

Influence of Gold Nanoparticles on the Kinetics of α-Synuclein Aggregation

(2013) Yanina D. Álvarez et al.   NANO LETTERS

BDNF-induced local protein synthesis and synaptic plasticity

(2013) Graciano Leal et al.   NEUROPHARMACOLOGY

Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer’s Disease

(2013) Jere E. Meredith Jr. et al.   PLoS One

Early Alzheimer’s and Parkinson’s Disease Pathology in Urban Children: Friend versus Foe Responses—It Is Time to Face the Evidence

(2013) Lilian Calderón-Garcidueñas et al.   Biomed Research International

Brain immune interactions and air pollution: macrophage inhibitory factor (MIF), prion cellular protein (PrPC), Interleukin-6 (IL-6), interleukin 1 receptor antagonist (IL-1Ra), and interleukin-2 (IL-2) in cerebrospinal fluid and MIF in serum differentiate urban children exposed to severe vs. low air pollution

(2013) Lilian Calderón-Garcidueñas et al.   Frontiers in Neuroscience

Air pollution is associated with brainstem auditory nuclei pathology and delayed brainstem auditory evoked potentials

(2011) Lilian Calderón-Garcidueñas et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Identifying Earlier Alzheimer’s Disease: Insights from the Preclinical and Prodromal Phases

(2011) Jose Luis Molinuevo et al.   Neurodegenerative Diseases

Temporal variation of nitro-polycyclic aromatic hydrocarbons in PM10 and PM2.5 collected in Northern Mexico City

(2010) B.L. Valle-Hernández et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor and Cognitive Function in Non-Demented Subjects

(2009) Ge Li et al.   PLoS One

CSF Multianalyte Profile Distinguishes Alzheimer and Parkinson Diseases

(2008) Jing Zhang et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs

(2008) Lilian Calderón-Garcidueñas et al.   BRAIN AND COGNITION

Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults

(2008) Lilian Calderón-Garcidueñas et al.   TOXICOLOGIC PATHOLOGY