Natural forms of vitamin E and metabolites—regulation of cancer cell death and underlying mechanisms

Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma

(2018) Allison J. Burbank et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Vitamin E δ-tocotrienol inhibits TNF-α-stimulated NF-κB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides

(2018) Chao Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A short course of gamma-tocopherol mitigates LPS-induced inflammatory responses in humans ex vivo

(2017) Allison J. Burbank et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment

(2017) Yumi Jang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

δ-Tocotrienol, a natural form of vitamin E, inhibits pancreatic cancer stem-like cells and prevents pancreatic cancer metastasis

(2017) Kazim Husain et al.   Oncotarget

Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites

(2016) Amit Mahipal et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Pleiotropic Effects of Tocotrienols and Quercetin on Cellular Senescence: Introducing the Perspective of Senolytic Effects of Phytochemicals

(2016) Marco Malavolta et al.   CURRENT DRUG TARGETS

Vitamin E metabolite 13′-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in mice

(2016) Yumi Jang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential: a molecular and clinicopathological study

(2015) David de Gonzalo-Calvo et al.   BMC CANCER

Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway

(2015) Wenyi Gu et al.   BMC CANCER

Vitamin E γ-Tocotrienol Inhibits Cytokine-Stimulated NF-κB Activation by Induction of Anti-Inflammatory A20 via Stress Adaptive Response Due to Modulation of Sphingolipids

(2015) Yun Wang et al.   JOURNAL OF IMMUNOLOGY

Analysis of vitamin E metabolites including carboxychromanols and sulfated derivatives using LC/MS/MS

(2015) Qing Jiang et al.   JOURNAL OF LIPID RESEARCH

Elimination of ALDH+ breast tumor initiating cells by docosahexanoic acid and/or gamma tocotrienol through SHP-1 inhibition of Stat3 signaling

(2015) Ailian Xiong et al.   MOLECULAR CARCINOGENESIS

δ-Tocotrienol Induces Human Bladder Cancer Cell Growth Arrest, Apoptosis and Chemosensitization through Inhibition of STAT3 Pathway

(2015) Changxiao Ye et al.   PLoS One

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

(2015) Fabienne Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure

(2015) Katsumori Segawa et al.   TRENDS IN CELL BIOLOGY

Pharmacological Targeting SHP-1-STAT3 Signaling Is a Promising Therapeutic Approach for the Treatment of Colorectal Cancer

(2015) Li-Ching Fan et al.   NEOPLASIA

A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia

(2015) Gregory M. Springett et al.   EBioMedicine

Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells

(2014) Su-Wen Lim et al.   BMC Complementary and Alternative Medicine

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

(2014) Shuhua Yue et al.   Cell Metabolism

Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy

(2014) Qing Jiang   FREE RADICAL BIOLOGY AND MEDICINE

Potent Inhibitory Effect of δ-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo

(2014) Huarong Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The therapeutic value of targeting inflammation in gastrointestinal cancers

(2014) Beicheng Sun et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Potential role of tocotrienols in the treatment and prevention of breast cancer

(2013) Paul W. Sylvester et al.   BIOFACTORS

Vitamin E  -Tocotrienol Prolongs Survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) Transgenic Mouse Model of Pancreatic Cancer

(2013) K. Husain et al.   Cancer Prevention Research

Effect of annatto-tocotrienols supplementation on the development of mammary tumors in HER-2/neu transgenic mice

(2013) E. Pierpaoli et al.   CARCINOGENESIS

Large-scale independent validation of the nuclear factor-kappa B p65 prognostic biomarker in prostate cancer

(2013) Philippe O. Gannon et al.   EUROPEAN JOURNAL OF CANCER

Gamma-tocopherol attenuates moderate but not severe colitis and suppresses moderate colitis-promoted colon tumorigenesis in mice

(2013) Qing Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

γ-Tocotrienol Induces Paraptosis-Like Cell Death in Human Colon Carcinoma SW620 Cells

(2013) Jing-Shu Zhang et al.   PLoS One

Mitochondrial Regulation of Cell Death

(2013) S. W. G. Tait et al.   Cold Spring Harbor Perspectives in Biology

NFκB signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression

(2012) P McCall et al.   BRITISH JOURNAL OF CANCER

Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol

(2012) Archana Gopalan et al.   CANCER LETTERS

Dietary Administration of  - and  -Tocopherol Inhibits Tumorigenesis in the Animal Model of Estrogen Receptor-Positive, but not HER-2 Breast Cancer

(2012) A. K. Smolarek et al.   Cancer Prevention Research

First Evidence That  -Tocotrienol Inhibits the Growth of Human Gastric Cancer and Chemosensitizes It to Capecitabine in a Xenograft Mouse Model through the Modulation of NF- B Pathway

(2012) K. A. Manu et al.   CLINICAL CANCER RESEARCH

Disruption of Mouse Cytochrome P450 4f14 (Cyp4f14Gene) Causes Severe Perturbations in Vitamin E Metabolism

(2012) Sabrina A. Bardowell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism

(2012) Sabrina A. Bardowell et al.   JOURNAL OF LIPID RESEARCH

γ-Tocotrienol inhibits lipopolysaccharide-induced interlukin-6 and granulocyte colony-stimulating factor by suppressing C/EBPβ and NF-κB in macrophages

(2012) Yun Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells

(2012) Archana Gopalan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dysregulation of sphingolipid metabolism in cancer

(2011) Lindsay K. Ryland et al.   CANCER BIOLOGY & THERAPY

Targeting apoptosis pathways by Celecoxib in cancer

(2011) Verena Jendrossek   CANCER LETTERS

 -Tocopherol Is More Active than  - or  -Tocopherol in Inhibiting Lung Tumorigenesis In Vivo

(2011) G.-X. Li et al.   Cancer Prevention Research

Tocotrienol as a potential anticancer agent

(2011) M. T. Ling et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Tocotrienols inhibit AKT and ERK activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway

(2011) Sonyo Shin-Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tocotrienols fight cancer by targeting multiple cell signaling pathways

(2011) Ramaswamy Kannappan et al.   Genes and Nutrition

Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide

(2011) Qing Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

Vitamin E and the Risk of Prostate Cancer

(2011) Eric A. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice

(2011) Asaf A Qureshi et al.   Lipids in Health and Disease

Vitamin E  -Tocotrienol Augments the Antitumor Activity of Gemcitabine and Suppresses Constitutive NF- B Activation in Pancreatic Cancer

(2011) K. Husain et al.   MOLECULAR CANCER THERAPEUTICS

Direct, Noncatalytic Mechanism of IKK Inhibition by A20

(2011) Brian Skaug et al.   MOLECULAR CELL

Return to homeostasis: downregulation of NF-κB responses

(2011) Jürgen Ruland   NATURE IMMUNOLOGY

Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling

(2010) Sook Kyung Park et al.   BREAST CANCER RESEARCH AND TREATMENT

 -Tocotrienol Inhibits Pancreatic Tumors and Sensitizes Them to Gemcitabine Treatment by Modulating the Inflammatory Microenvironment

(2010) A. B. Kunnumakkara et al.   CANCER RESEARCH

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress

(2010) Marc Birringer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Natural Forms of Vitamin E and 13'-Carboxychromanol, a Long-Chain Vitamin E Metabolite, Inhibit Leukotriene Generation from Stimulated Neutrophils by Blocking Calcium Influx and Suppressing 5-Lipoxygenase Activity, Respectively

(2010) Z. Jiang et al.   JOURNAL OF IMMUNOLOGY

Mixed Tocotrienols Inhibit Prostate Carcinogenesis in TRAMP Mice

(2010) Avantika Barve et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

In vivo Evidence of γ-Tocotrienol as a Chemosensitizer in the Treatment of Hormone-Refractory Prostate Cancer

(2010) W.N. Yap et al.   PHARMACOLOGY

Endoplasmic reticulum stress mediates γ-tocotrienol-induced apoptosis in mammary tumor cells

(2009) Vikram B. Wali et al.   APOPTOSIS

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Cancer-preventive activities of tocopherols and tocotrienols

(2009) Jihyeung Ju et al.   CARCINOGENESIS

Mixed Tocopherols Prevent Mammary Tumorigenesis by Inhibiting Estrogen Action and Activating PPAR- 

(2009) H. J. Lee et al.   CLINICAL CANCER RESEARCH

γ-Tocotrienol and γ-Tocopherol Are Primarily Metabolized to Conjugated 2-(β-carboxyethyl)-6-Hydroxy-2,7,8-Trimethylchroman and Sulfated Long-Chain Carboxychromanols in Rats

(2009) Helene Freiser et al.   JOURNAL OF NUTRITION

Tocotrienols Suppress Proinflammatory Markers and Cyclooxygenase-2 Expression in RAW264.7 Macrophages

(2009) Mun-Li Yam et al.   LIPIDS

Suppression in Mevalonate Synthesis Mediates Antitumor Effects of Combined Statin and γ-Tocotrienol Treatment

(2009) Vikram B. Wali et al.   LIPIDS

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

d-δ-Tocotrienol-Mediated Suppression of the Proliferation of Human PANC-1, MIA PaCa-2, and BxPC-3 Pancreatic Carcinoma Cells

(2009) Deema Hussein et al.   PANCREAS

Vitamin E δ-Tocotrienol Levels in Tumor and Pancreatic Tissue of Mice after Oral Administration

(2009) Kazim Husain et al.   PHARMACOLOGY

Suppression of prostate cancer in a transgenic rat model via γ-tocopherol activation of caspase signaling

(2009) Satoru Takahashi et al.   PROSTATE

γ-Tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways

(2008) W N Yap et al.   BRITISH JOURNAL OF CANCER

In vivo γ-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects

(2008) Jessica Wiser et al.   FREE RADICAL BIOLOGY AND MEDICINE

Specific accumulation of γ- and δ-tocotrienols in tumor and their antitumor effect in vivo

(2008) Yuhei Hiura et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases

(2008) Q. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γ-Tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma

(2007) J. G. Wagner et al.   CLINICAL AND EXPERIMENTAL ALLERGY