Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment

Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes

(2018) Xing Deng et al.   Cell Stem Cell

Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury

(2018) Shengda Lin et al.   NATURE

A pivotal role of BEX1 in liver progenitor cell expansion in mice

(2018) Yuting Gu et al.   Stem Cell Research & Therapy

De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation

(2018) Johanna R. Schaub et al.   NATURE

Interventional Potential of Recombinant Feline Hepatocyte Growth Factor in a Mouse Model of Non-alcoholic Steatohepatitis

(2018) Yoon Mee Yang et al.   Frontiers in Endocrinology

Hepatostat: Liver regeneration and normal liver tissue maintenance

(2017) George K. Michalopoulos   HEPATOLOGY

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

(2017) Alexander Raven et al.   NATURE

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Update on the Mechanisms of Liver Regeneration

(2017) Morgan Preziosi et al.   SEMINARS IN LIVER DISEASE

Upstream regulators of hepatic Wnt/β-catenin activity control liver metabolic zonation, development, and regeneration

(2016) Laure-Alix Clerbaux et al.   HEPATOLOGY

Hedgehog regulates yes-associated protein 1 in regenerating mouse liver

(2016) Marzena Swiderska-Syn et al.   HEPATOLOGY

Functional analysis of the relationship between intestinal microbiota and the expression of hepatic genes and pathways during the course of liver regeneration

(2016) Hui-Xin Liu et al.   JOURNAL OF HEPATOLOGY

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

(2016) Lara Planas-Paz et al.   NATURE CELL BIOLOGY

Perioperative hepatocyte growth factor (HGF) infusions improve hepatic regeneration following portal branch ligation (PBL) in rodents

(2016) Christopher W. Mangieri et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration

(2016) Wenjuan Pu et al.   Nature Communications

Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling

(2016) Kenji Kamimoto et al.   eLife

Novel bile acid therapeutics for the treatment of chronic liver diseases

(2016) Vinod S. Hegade et al.   Therapeutic Advances in Gastroenterology

Notch Signaling Coordinates Progenitor Cell-Mediated Biliary Regeneration Following Partial Hepatectomy

(2016) Jie Lu et al.   Scientific Reports

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

(2015) Joan Font-Burgada et al.   CELL

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

The Bile Acid Receptor TGR5 and Liver Regeneration

(2015) Valeska Jourdainne et al.   DIGESTIVE DISEASES

Ablation of Foxl1-Cre–Labeled Hepatic Progenitor Cells and Their Descendants Impairs Recovery of Mice From Liver Injury

(2015) Soona Shin et al.   GASTROENTEROLOGY

Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis

(2015) Zhen-Wei Peng et al.   HEPATOLOGY

Inhibition of hedgehog signaling ameliorates hepatic inflammation in mice with nonalcoholic fatty liver disease

(2015) Hyunjoo Kwon et al.   HEPATOLOGY

Lineage fate of ductular reactions in liver injury and carcinogenesis

(2015) Simone Jörs et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment

(2015) Xueru Mu et al.   JOURNAL OF CLINICAL INVESTIGATION

Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse

(2015) Pedro Melgar-Lesmes et al.   JOURNAL OF HEPATOLOGY

Implications of microbiota and bile acid in liver injury and regeneration

(2015) Hui-Xin Liu et al.   JOURNAL OF HEPATOLOGY

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Hepatic progenitor cells of biliary origin with liver repopulation capacity

(2015) Wei-Yu Lu et al.   NATURE CELL BIOLOGY

Hepatocytes, Rather than Cholangiocytes, Can Be the Major Source of Primitive Ductules in the Chronically Injured Mouse Liver

(2014) Sayaka Sekiya et al.   AMERICAN JOURNAL OF PATHOLOGY

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

(2014) Kilangsungla Yanger et al.   Cell Stem Cell

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

(2014) Branden D. Tarlow et al.   Cell Stem Cell

The biliary epithelium gives rise to liver progenitor cells

(2014) Daniel Rodrigo-Torres et al.   HEPATOLOGY

Sry HMG Box Protein 9-positive (Sox9+) Epithelial Cell Adhesion Molecule-negative (EpCAM−) Biphenotypic Cells Derived from Hepatocytes Are Involved in Mouse Liver Regeneration

(2014) Naoki Tanimizu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis

(2014) Dirk Drasdo et al.   JOURNAL OF HEPATOLOGY

Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury

(2014) Johanna R. Schaub et al.   Cell Reports

Polyploidization in Liver Tissue

(2013) Géraldine Gentric et al.   AMERICAN JOURNAL OF PATHOLOGY

FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration

(2013) H. M. Takase et al.   GENES & DEVELOPMENT

Robust cellular reprogramming occurs spontaneously during liver regeneration

(2013) K. Yanger et al.   GENES & DEVELOPMENT

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

(2013) Noémie Péan et al.   HEPATOLOGY

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration

(2012) Yuichiro Miyaoka et al.   CURRENT BIOLOGY

Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice

(2012) Regina Español–Suñer et al.   GASTROENTEROLOGY

Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice

(2012) Prachi Borude et al.   HEPATOLOGY

Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats

(2012) Lin Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Kupffer Cells Influence Parenchymal Invasion and Phenotypic Orientation, but Not the Proliferation, of Liver Progenitor Cells in a Murine Model of Liver Injury

(2011) Noémi Van Hul et al.   AMERICAN JOURNAL OF PATHOLOGY

Embryonic Ductal Plate Cells Give Rise to Cholangiocytes, Periportal Hepatocytes, and Adult Liver Progenitor Cells

(2011) Rodolphe Carpentier et al.   GASTROENTEROLOGY

Hepatocyte growth factor/c-metsignaling is required for stem-cell-mediated liver regeneration in mice

(2011) Tsuyoshi Ishikawa et al.   HEPATOLOGY

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

(2011) Yann Malato et al.   JOURNAL OF CLINICAL INVESTIGATION

New concepts in liver regeneration

(2011) Kimberly J Riehle et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways

(2011) Ai-Luen Wu et al.   PLoS One

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells

(2010) S. Tamir Rashid et al.   JOURNAL OF CLINICAL INVESTIGATION

Hedgehog signaling in the liver

(2010) Alessia Omenetti et al.   JOURNAL OF HEPATOLOGY

FXR Regulates Liver Repair after CCl4-Induced Toxic Injury

(2010) Zhipeng Meng et al.   MOLECULAR ENDOCRINOLOGY

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Stem Cells and Liver Regeneration

(2009) Andrew W. Duncan et al.   GASTROENTEROLOGY

Targeting liver fibrosis: Strategies for development and validation of antifibrotic therapies

(2009) Yury Popov et al.   HEPATOLOGY

The histogenesis of regenerative nodules in human liver cirrhosis

(2009) Wey-Ran Lin et al.   HEPATOLOGY

Transcription dynamics in a physiological process: β-Catenin signaling directs liver metabolic zonation

(2009) Cyril Torre et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies

(2008) Yury Popov et al.   JOURNAL OF HEPATOLOGY

Endocrine and paracrine role of bile acids

(2008) Verena Keitel et al.   WORLD JOURNAL OF GASTROENTEROLOGY